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Cancer incidence in patients with schizophrenia and their first‐degree relatives – a meta‐analysis
Abstract
Objective: Controversy concerning cancer incidence in schizophrenia exists because of heterogeneous study findings. Method: A meta‐analysis was performed on standardized incidence ratios (SIR) of cancer in patients with schizophrenia and first‐degree relatives and compared with general population samples. Results: The pooled overall cancer incidence in patients was not significantly increased (SIR = 1.05, CI 0.95–1.15). Lung cancer incidence was slightly increased (SIR = 1.31, CI 1.01–1.71), but was reduced after adjusting for smoking prevalence. The incidence of several cancers unrelated to smoking was reduced in patients. Breast cancer rates were significantly increased in female patients. The pooled overall cancer incidence in siblings (SIR = 0.89, CI 0.84–0.94) and parents (SIR = 0.90, CI 0.88–0.93) was significantly reduced. A meta‐regression detected a significant relationship between cancer risk in the general population and relative risk in patients. Conclusion: The meta‐analysis aided exploration of inconsistent study findings. There is a discrepancy between cancer risk exposure and cancer incidence in schizophrenia consistent with a protective effect.
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“On the other hand, other studies found an increased (9,21,28,(449)(450)(451) or no different (292,419,452,453) overall risk of cancer in patients with schizophrenia compared to the general population.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [453]
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Metadata
- Authors
- Catts, V. S., Catts, S. V., O’Toole, B. I., & Frost, A. D. J.
- Affiliations
- The University of Queensland (AU)
- The University of Sydney (AU)
- Royal Brisbane and Women's Hospital (AU)
- Corresponding author
- Catts, V. S.
- Catts, S. V.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2008-03-10
- Volume
- 117
- Issue
- 5
- Pages
- 323-336
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W1965388866
- Cited by
- 209
- References
- 63
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 15 · 2017: 14 · 2016: 12 · 2015: 12 · 2014: 18 · 2013: 15 · 2012: 13
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- schizophrenia, cancer incidence, lung cancer, breast cancer, first-degree relatives, siblings, parents, smoking, standardized incidence ratio, cancer risk
- MeSH terms
- Aged, Urinary Bladder Neoplasms, Humans, Lung Neoplasms, Neoplasms, Risk Factors, Schizophrenia, Incidence, Prevalence
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