Risk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969–1993
Abstract
We investigated the cancer risk of patients hospitalized for schizophrenia in a nationwide cohort study. All 22766 adults admitted for schizophrenia, ICD-8 295, in Denmark between 1969 and 1993 were followed up for cancer through 1995. The incidence of site-specific cancers was compared with national incidence rates, adjusted for sex, age and calendar time. The risk for cancer was increased for both men and women during the first year of follow-up. When the first year of follow-up was excluded, the risk for all tobacco-associated cancers and for prostate and rectal cancers was reduced for male patients with schizophrenia. The standardized incidence ratio (SIR) of lung cancer was marginally reduced (SIR, 0.86; 95% CI: 0.65, 1.02) for male patients with schizophrenia; this was due, however, to a reduction in risk for older patients. An increased risk for breast cancer found for female patients with schizophrenia (SIR, 1.20; 95% CI: 1.05, 1.38) should be interpreted with caution, given the high proportion of nulliparous women with schizophrenia in Denmark. The data might support reduced risks for prostate and rectal cancer among male patients with schizophrenia, whereas a changing smoking pattern might explain the reduced risk for tobacco-related cancers.
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Some studies have demonstrated a decreased cancer risk in schizophrenia.
“Some studies have demonstrated a decreased cancer risk in schizophrenia (440-448).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [445]
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- Authors
- Dalton, S. O., Mellemkjær, L., Thomassen, L., Mortensen, P. B., & Johansen, C.
- Affiliations
- Danish Cancer Society (DK)
- Aarhus University (DK)
- Corresponding author
- Dalton, Susanne Oksbjerg
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 75
- Issue
- 2-3
- Pages
- 315-324
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2090248954
- Cited by
- 142
- References
- 32
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 2 · 2015: 11 · 2014: 6 · 2013: 6 · 2012: 10
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Danmarks Grundforskningsfond
- Fonds National de la Recherche Luxembourg
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- schizophrenia, cancer risk
- MeSH terms
- Adolescent, Adult, Aged, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasms, Risk Factors, Schizophrenia, Cohort Studies, Incidence
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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