CSF biomarkers in suicide attempters – a principal component analysis
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Lindqvist D, Janelidze S, Erhardt S, Träskman‐Bendz L, Engström G, Brundin L. CSF biomarkers in suicide attempters – a principal component analysis. Objective: The objective of the present study was to identify biological patterns (factors) among 20 cerebrospinal fluid (CSF) biomarkers in suicide attempters and subsequently analyse their association with suicidal behaviour. Method: We measured kynurenic acid, orexin, homovanillic acid (HVA), 5‐hydroxyindoleacetic acid (5‐HIAA), 3‐methoxy‐4‐hydroxyphenylglycol, chemokines, matrix metalloproteases and cytokines in the CSF of 124 drug‐free suicide attempters. Patients were evaluated for suicidality and psychiatric symptoms using well‐defined psychiatric rating scales and followed‐up regarding future suicide. We used principal component analysis to identify factors among the biological substances. Results: Four factors were extracted from the 20 biomarkers, explaining 52.4% of the total variance. Factors 1 and 2 were characterized by high loadings of chemokines and cytokines respectively. They were both associated with severe depressive symptoms. Factor 2 was also associated with a high suicidal intent. Factor 4 was characterized by strong loadings of the monoamine metabolites 5‐HIAA and HVA, as well as orexin and interleukin‐6. High scores on this factor were found in patients who performed a violent suicide attempt and in patients who subsequently completed suicide. Conclusion: Our results suggest that specific combinations of CSF biomarkers may discriminate between types of suicidal behaviour and indicate increased risk for future suicide.
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Some studies reported mixed results regarding CSF MCP-1 in depression.
“Other studies presented either mixed results (Lindqvist et al., 2011)”
From A Review of the Relationship between Proinflammatory Cytokines and Major Depressive Disorder (2014) · cites this paper as Lindqvist et al., 2011
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- Authors
- Lindqvist, D., Janelidze, S., Erhardt, S., Träskman‐Bendz, L., Engström, G., & Brundin, L.
- Affiliations
- Skåne University Hospital (SE)
- Karolinska Institutet (SE)
- Lund University (SE)
- Corresponding author
- Lindqvist, D.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2010-12-28
- Volume
- 124
- Issue
- 1
- Pages
- 52-61
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W1848493697
- Cited by
- 86
- References
- 65
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 6
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- AstraZeneca
- Lunds Universitet
- Lundbeckfonden
- Vetenskapsrådet (14548-04-3, K2009-61X-21524-01-1, 14548)
- H. Lundbeck A/S
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- suicide attempters, cerebrospinal fluid biomarkers, suicidal behavior, chemokines, cytokines, kynurenic acid, orexin, homovanillic acid, 5-hydroxyindoleacetic acid, MHPG, interleukin-6, depressive symptoms, suicidal intent, violent suicide attempts, suicide mortality, suicide risk prediction
- MeSH terms
- Orexins, Adult, Female, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Kynurenic Acid, Male, Methoxyhydroxyphenylglycol, Neuropeptides, Suicide, Attempted, Biomarkers, Cytokines, Chemokines, Matrix Metalloproteinases, Principal Component Analysis, Intracellular Signaling Peptides and Proteins
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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