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Cited by 65Hematopoietic Stem Cell TransplantationDevelopmental Biology and Gene RegulationZebrafish Biomedical Research Applications

The embryonic origins of hematopoietic stem cells: a tale of hemangioblast and hemogenic endothelium

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BOLLEROT, KARINE, POUGET, CLAIRE, JAFFREDO, THIERRY·2005·APMIS
DOI 10.1111/j.1600-0463.2005.apm_317.x
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Abstract

The developmental origin of hematopoietic stem cells has been for decades the subject of great interest. Once thought to emerge from the yolk sac, hematopoietic stem cells have now been shown to originate from the embryonic aorta. Increasing evidence suggests that hematopoietic stem cells are produced from an endothelial intermediate designated by the authors as hemangioblast or hemogenic endothelium. Recently, the allantois in the avian embryo and the placenta in the mouse embryo were shown to be a site of hematopoietic cell production/expansion and thus appear to play a critical role in the formation of the hematopoietic system. In this review we shall give an overview of the data obtained from human, mouse and avian models on the cellular origins of the hematopoietic system and discuss some aspects of the molecular mechanisms controlling hematopoietic cell production.

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  • HSECs present in the early liver are derived from the hemangioblast, from which vascular endothelial cells and early hematopoietic cells are also derived.

    “HSECs present in the early liver are derived from the hemangioblast, from which vascular endothelial cells and early hematopoietic cells are also derived”

    From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Bollerot et al., 2005

    The “Hemangioblast or hemogenic endothelium?” section describes the hemangioblast as a proposed common progenitor of endothelial and hematopoietic cells. The Concluding Remarks say that hemangioblasts in fetal liver have been reported but need confirmation; they do not establish that early-liver HSECs derive from hemangioblasts. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Authors
BOLLEROT, K., POUGET, C., & JAFFREDO, T.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
JAFFREDO, THIERRY
ORCID
Venue
APMIS
Publisher
Wiley
Published
2005-11
Volume
113
Issue
11-12
Pages
790-803
ISSN
  • 0903-4641 (ISSN-L)
  • 1600-0463
DOI
10.1111/j.1600-0463.2005.apm_317.x
OpenAlex
W2073894195
Cited by
65
References
3
Citations by year
2025: 3 · 2024: 4 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
0.95
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 105 d)
Locations
  • Apmis (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centre National de la Recherche Scientifique
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
Keywords
hematopoietic stem cells, embryonic hematopoiesis, hemangioblasts, hemogenic endothelium, yolk sac, allantois, placenta, avian embryo, mouse embryo
MeSH terms
Allantois, Animals, Aorta, Chick Embryo, Embryo, Mammalian, Endothelium, Vascular, Hematopoiesis, Hematopoietic Stem Cells, Hematopoietic System, Humans, Yolk Sac, Cell Lineage, Mice

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