Molecular Identity of Hematopoietic Precursor Cells Emerging in the Human Embryo
Abstract
It is now accepted from studies in animal models that hematopoietic stem cells emerge in the para-aortic mesoderm-derived aorta-gonad-mesonephros region of the vertebrate embryo. We have previously identified the equivalent primitive hematogenous territory in the 4- to 6-week human embryo, under the form of CD34+CD45+Lin− high proliferative potential hematopoietic cells clustered on the ventral endothelium of the aorta. To characterize molecules involved in initial stem cell emergence, we first investigated the expression in that territory of known early hematopoietic regulators. We herein show that aorta-associated CD34+ cells coexpress the tal-1/SCL, c-myb, GATA-2, GATA-3, c-kit, and flk-1/KDR genes, as do embryonic and fetal hematopoietic progenitors later present in the liver and bone marrow. Next, CD34+CD45+ aorta-associated cells were sorted by flow cytometry from a 5-week embryo and a cDNA library was constructed therefrom. Differential screening of that library with total cDNA probes obtained from CD34+embryonic liver cells allowed the isolation of a kinase-related sequence previously identified in KG-1 cells. In addition to emerging blood stem cells, KG-1 kinase is also strikingly expressed in all developing endothelial cells in the yolk sac and embryo, which suggests its involvement in the genesis of both hematopoietic and vascular cell lineages in humans.
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The Gata3, Gata2 and Tal1 module is best known as master regulator of haematopoietic development, and is an example of repurposing the same transcription factor module for specifying cell types in different systems.
“Of note, the latter gene module is best known as master regulator of haematopoietic development90, and is an example of repurposing the same transcription factor module for specifying cell types in different systems.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [90]
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- Authors
- Labastie, M.-C., Cortés, F., Roméo, P.-H., Dulac, C., & Péault, B.
- Affiliations
- Howard Hughes Medical Institute (US)
- From Institut d’Embryologie Cellulaire et Moléculaire-CNRS UPR 9064, Nogent-sur-Marne, France; Unité de Recherche en Hématopoı̈èse Moléculaire-INSERM U474, Hôpital Henri Mondor, Créteil, France; and the Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA.
- ORCID
- Dulac, Catherine
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1998-11-15
- Volume
- 92
- Issue
- 10
- Pages
- 3624-3635
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1552184745
- Cited by
- 153
- References
- 67
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 9
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- human embryo, aorta-gonad-mesonephros, CD34+CD45+ cells, MYB, GATA2, GATA3, CD117, KDR/Flk-1, endothelial cells, yolk sac, hematopoietic progenitor cells, hematopoietic lineage
- MeSH terms
- Antigens, Differentiation, Aorta, Endothelium, Vascular, Enzyme Induction, Fetal Proteins, Gestational Age, Hematopoietic Stem Cells, Hematopoietic System, Humans, Liver, Organ Specificity, Transcription Factors, Yolk Sac, Blotting, Southern, Protein Serine-Threonine Kinases, In Situ Hybridization, Leukocyte Common Antigens, DNA, Complementary, Gene Expression Regulation, Developmental, Antigens, CD34
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