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Cited by 49Antioxidant Activity and Oxidative StressWound Healing and TreatmentsOral microbiology and periodontitis research

Reduction of collagen degradation in experimental granulation tissue by vitamin E and selenium

Åsman, B., Wijkander, P., Hjerpe, A.·1994·Journal Of Clinical Periodontology
DOI 10.1111/j.1600-051x.1994.tb00275.x
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Abstract

The importance of antioxidants in inflammatory tissues has been studied in vivo. Degradation of homologous 3H-collagen powder by experimental granulation tissue induced by cellulose sponges in the rat was monitored as the radioactivity excreted in urine. By administering pharmacological doses of both vitamin E and selenium subcutaneously and by injection into sponges implanted subcutaneously, this breakdown of collagen was reduced. Injections in the sponges also arrested the maturation of the granulation tissue. Vitamin E and selenium are potential inhibitors of the free oxygen radicals from phagocytic inflammatory cells. It is therefore suggested that these radicals may play a rôle in the collagen destruction by granulation tissues, as in periodontitis.

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Crossref · 10.1111/j.1600-051x.1994.tb00275.x

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Authors
Åsman, B., Wijkander, P., & Hjerpe, A.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Åsman, B.
Venue
Journal Of Clinical Periodontology
Publisher
Wiley
Published
1994-01
Volume
21
Issue
1
Pages
45-47
ISSN
  • 0303-6979 (ISSN-L)
  • 1600-051X
DOI
10.1111/j.1600-051x.1994.tb00275.x
OpenAlex
W2054908488
Cited by
49
References
9
Citations by year
2026: 1 · 2025: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2016: 4 · 2014: 2 · 2013: 5
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4364 d)
Locations
  • Journal Of Clinical Periodontology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
collagen degradation, granulation tissue, vitamin E, selenium, antioxidants, oxygen free radicals, periodontitis, tissue maturation
MeSH terms
Animals, Collagen, Edema, Extracellular Matrix, Granulation Tissue, Injections, Subcutaneous, Male, Neutrophils, Selenium, Skin, Tritium, Vitamin E, Surgical Sponges, Rats, Sprague-Dawley, Prostheses and Implants, Rats

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