Topical antioxidants protect the skin from chemical-induced irritation in the repetitive washing test: A placebo-controlled, double-blind study
Abstract
BACKGROUND: There is increasing evidence that reactive oxygen species play an important role in the development of both irritant and allergic contact dermatitis. OBJECTIVES: To assess the potential of topical antioxidants to prevent the development of experimentally induced irritant contact dermatitis. METHODS: We evaluated the effect of a cream containing a combination of antioxidants on sodium lauryl sulfate-induced irritant contact dermatitis in the repetitive washing test. As readout parameters for skin barrier function and cutaneous inflammation stratum corneum hydration, cutaneous blood flow and transepidermal water loss were assessed in 25 volunteers with bioengineering methods. RESULTS: In comparison with the cream base and a frequently used barrier cream, the antioxidant cream had high radical scavenging activity and effectively protected the skin from chemical-induced irritation. CONCLUSIONS: The superiority of the cream with antioxidants to the cream base suggests that reactive oxygen species, at least in part, play a role in the development of irritant contact dermatitis.
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A combination of vitamin E and C can help activate vitamin E, which protects skin against chemical stimuli and UV-induced irritation and damage by inhibiting lipid peroxidation in the skin.
“A combination of vitamin E and C can help activate vitamins E, which protects skin against chemical stimuli and UV-induced irritation and damage by inhibiting lipid peroxidation in the skin [102,103].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [103]
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Self-citationMechanisms of chemical-induced innate immunity in allergic contact dermatitis
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Self-citationRadical Protection by Sunscreens in the Infrared Spectral Range
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Effect of an antioxidant (quercetin) on sodium‐lauryl‐sulfate‐induced skin irritation
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EC-SOD Suppresses Contact Hypersensitivity in Mouse Skin by Impairing Langerhans Cell Migration
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Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
- Authors
- Schempp, C. M., Meinke, M. C., Lademann, J., Ferrari, Y., Brecht, T., & Gehring, W.
- Affiliations
- University Medical Center Freiburg (DE)
- Stiftung Charité (DE)
- Städtisches Klinikum Karlsruhe (DE)
- Corresponding author
- Schempp, Christoph M.
- Venue
- Contact Dermatitis
- Publisher
- Wiley
- Published
- 2012-05-25
- Volume
- 67
- Issue
- 4
- Pages
- 234-237
- ISSN
- 0105-1873 (ISSN-L)
- 1600-0536
- OpenAlex
- W1997750535
- Cited by
- 23
- References
- 15
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2017: 2 · 2016: 7 · 2015: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Contact Dermatitis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Health Professions › Speech and Hearing › Neonatal skin health care
- Keywords
- topical antioxidants, irritant contact dermatitis, sodium dodecyl sulfate, reactive oxygen species, skin barrier function, stratum corneum hydration, skin blood flow, transepidermal water loss, free radical scavenging, barrier creams
- MeSH terms
- Antioxidants, Double-Blind Method, Hand Dermatoses, Humans, Phytotherapy, Plant Extracts, Sodium Dodecyl Sulfate, Ubiquinone, Reactive Oxygen Species, Dermatitis, Irritant, Tocopherols, Resedaceae, Skin Cream
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