The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Prognostic implication and biological roles of RhoH in acute myeloid leukaemia
Abstract
The Rho family of small GTPases, including Rho, Rac and Cdc42, has been well characterised as a molecular switch that transduces signals from plasma membrane to the downstream effectors. RhoH gene, a member of the Rho family, is specifically expressed in haematopoietic cells. The known function of RhoH is antagonising Rac and mediating activation of ZAP‐70 in T lymphocytes; however, biological roles of RhoH in myeloid cells remain unknown. Here, we analysed the prognostic implication of the expression level of the RhoH gene transcript in bone marrow samples from 90 newly diagnosed acute myeloid leukaemia (AML) patients using a real‐time fluorescence detection method. Kaplan–Meier analysis demonstrated that low expression of the RhoH transcript was a predictor of worse prognosis in both overall and disease‐free survival. Multivariate analysis demonstrated that low expression of RhoH was an independent unfavourable prognostic factor for both overall and disease‐free survival of AML patients. Overexpression of RhoH leads to dephosphorylation of Bad at Serine 75 residue possibly through deactivation of Rac. It is possible that low expression of RhoH (i.e. high GTP‐Rac) contributes to chemotherapy resistance in leukaemia cells. Our result suggests that inhibition of Rac and its signalling components might provide a useful anti‐leukaemic strategy.
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In the citing paper
“while alterations in protein levels have been demonstrated for several Rho GTPases in solid tumors43,44,45 and leukemic cells46,47.”
From Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders (2013) · cites this paper as [47]
In the citing paper
“RhoH inhibits Rac1-induced Bad, a pro-apoptotic protein phosphorylation at Ser78, leading to the inhibition of apoptosis event [50].”
From The Role of RhoH in TCR Signalling and Its Involvement in Diseases (2021) · cites this paper as [50]
In the citing paper
“Aside from aSHM, low levels of RhoH were also observed in several patients with hairy cell leukaemia (HCL), acute myeloid leukaemia (AML) and CLL [50,58,59] but the mechanism involved in this protein levels deregulation is still unknown.”
From The Role of RhoH in TCR Signalling and Its Involvement in Diseases (2021) · cites this paper as [50]
In the citing paper
“In Hairy Cell Leukaemia (HCL) and Acute Myeloid Leukaemia (AML), RhoH was found to be underexpressed at the protein level [12,13].”
From The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression (2010) · cites this paper as [13]
In the citing paper
“It was recently shown that reduced RhoH levels can be connected to cancer and protection from apoptosis [10,12,13].”
From The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression (2010) · cites this paper as [13]
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Chae, H.-D., Lee, K. E., Williams, D. A., & Gu, Y. (2008) · Blood · doi:10.1182/blood-2007-06-093237 · Cited by 81
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Cited by
Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders
Troeger, A., & Williams, D. A. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.002 · Cited by 73
The small GTPase RhoH is an atypical regulator of haematopoietic cells
Fueller, F., & Kubatzky, K. F. (2008) · Cell Communication and Signaling · doi:10.1186/1478-811x-6-6 · Cited by 40
Gündogdu, M. S., Liu, H., Metzdorf, D., Hildebrand, D., Aigner, M., Aktories, K., Heeg, K., & Kubatzky, K. F. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-225 · Cited by 29
The Role of RhoH in TCR Signalling and Its Involvement in Diseases
Ahmad Mokhtar, A. M., Hashim, I. F., Mohd Zaini Makhtar, M., Salikin, N. H., & Amin-Nordin, S. (2021) · Cells · doi:10.3390/cells10040950 · Cited by 25
Troeger, A., Chae, H.-D., Senturk, M., Wood, J., & Williams, D. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.505727 · Cited by 15
Metadata
- Authors
- Iwasaki, T., Katsumi, A., Kiyoi, H., Tanizaki, R., Ishikawa, Y., Ozeki, K., Kobayashi, M., Abe, A., Matsushita, T., Watanabe, T., Amano, M., Kojima, T., Kaibuchi, K., & Naoe, T.
- Venue
- European Journal of Haematology
- Publisher
- Wiley
- Published
- 2008-11-18
- Volume
- 81
- Issue
- 6
- Pages
- 454-460
- ISSN
- 0902-4441
- 1600-0609
- Cited by
- 24
- References
- 3
- Language
- en
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