The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The role of microRNAs in normal and malignant hematopoiesis
Open accessAbstract
MicroRNAs are small non‐coding RNAs that act at the post‐transcriptional level, regulating protein expression by repressing translation or destabilizing mRNA target. Because of their discovery, microRNAs have been associated with almost every normal cell function, including proliferation, differentiation and apoptosis. Several lines of evidence suggest that they have an important role in normal hematopoiesis as exemplified by the role of mir‐155 and mir‐150 in the differentiation of B and T lymphocytes, the suppressive role of mir‐221 and mir‐222 in erythroid differentiation, the inhibitory effect of mir‐181 on hematopoietic differentiation and the induction of myeloid differentiation by mir‐223. Moreover, they play a role both as oncogenes, probably by a variety of mechanisms, namely through elimination of tumor suppressor proteins, or as tumor suppressor genes by targeting oncogenic mRNAs. Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir‐15a and mir‐16‐1 in chronic lymphocytic leukemia, the increased levels of mir‐155 in diffuse large B‐cell lymphomas and the increased levels of mir‐181 in acute myeloid leukemia M1 and M2. The purpose of this review is to summarize current knowledge on the role of microRNAs in normal hematopoiesis and hematopoietic malignancies and, moreover, to highlight their role as potential therapeutic tools.
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Cites
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Cited by
Assessing sample and miRNA profile quality in serum and plasma or other biofluids
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Haemolysis during sample preparation alters microRNA content of plasma
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Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury
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Digging deep into “dirty” drugs – modulation of the methylation machinery
Pleyer, L., & Greil, R. (2015) · Drug Metabolism Reviews · doi:10.3109/03602532.2014.995379 · Cited by 84
“Micro-RNAs are recognized as one of the major pillars that regulate gene expression and have been associated with most cellular functions, as well as with normal and malignant hematopoiesis (Vasilatou et al., 2010).”
BackgroundDaily variations in the expression of miR-16 and miR-181a in human leukocytes
de Siqueira Figueredo, D., Gitaí, D. L. G., & de Andrade, T. G. (2015) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2015.01.004 · Cited by 27
Metadata
- Authors
- Vasilatou, D., Papageorgiou, S., Pappa, V., Papageorgiou, E., & Dervenoulas, J.
- Venue
- European Journal of Haematology
- Publisher
- Wiley
- Published
- 2009-12-11
- Volume
- 84
- Issue
- 1
- Pages
- 1-16
- ISSN
- 0902-4441 (ISSN-L)
- 1600-0609
- OpenAlex
- W1603432390
- Cited by
- 189
- References
- 12
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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