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Cited by 46Skin Protection and AgingDermatological and Skeletal DisordersDermatologic Treatments and Research

Extracellular matrix in cutaneous ageing: the effects of 0.1% copper–zinc malonate‐containing cream on elastin biosynthesis

Mahoney, Mỹ G., Brennan, Donna, Starcher, Barry, Faryniarz, Joseph, Ramirez, Jose, Parr, Lisa, Uitto, Jouni·2009·Experimental Dermatology
DOI 10.1111/j.1600-0625.2008.00783.x
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Abstract

Cutaneous ageing, as visualized at the exposed areas of skin, reflects dramatic alterations in the structure and function of the extracellular matrix of connective tissues. Among them, the elastic fibre network, which is responsible for the physiological elasticity and resilience of normal skin, undergoes degradative changes leading to loss of functional elastic fibres. A potential strategy to counteract these degenerative changes entails topical application of a compound that may lead to regeneration of the elastic fibre network. In this study, we have evaluated the effects of a bi-metal, 0.1% copper-zinc malonate-containing cream that has been shown to efface wrinkles in clinical trials. An effect on elastin biosynthesis and elastic tissue accumulation in skin biopsies was observed in 21 female patients with photoaged facial skin, as measured at baseline and at 6 weeks of treatment. Histopathological evaluation revealed evidence of elastic fibre regeneration, including those extending perpendicularly towards the dermo-epidermal junction within the papillary dermis. Elastin biosynthesis, measured by semi-quantitative immunofluorescence with an antibody recognizing only the newly synthesized, uncrosslinked tropoelastin molecules, suggested statistically significant enhancement of elastin biosynthesis by the bi-metal compound when applied twice daily. Accumulation of elastic fibres was confirmed by assay of desmosine, an elastin-specific crosslink compound. These results suggest that the bi-metal, 0.1% copper-zinc malonate-containing cream has the propensity to increase elastin synthesis in human skin in vivo, and that regeneration of elastic fibres may contribute to wrinkle effacement in female patients with photoaged facial skin.

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Crossref · 10.1111/j.1600-0625.2008.00783.x

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  • A 0.1% copper-zinc malonate cream applied topically for 6 weeks significantly reduced wrinkles.

    “Zinc administered orally or topically has been shown to have therapeutic applications in skin ageing (a 0.1% copper–zinc malonate cream applied topically for 6 weeks significantly reduced wrinkles) [111]”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [111]

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Authors
Mahoney, M. G., Brennan, D., Starcher, B., Faryniarz, J., Ramirez, J., Parr, L., & Uitto, J.
Affiliations
  • Thomas Jefferson University (US)
  • The University of Texas Health Science Center at Tyler (US)
Corresponding author
Uitto, Jouni
ORCID
Uitto, Jouni
Venue
Experimental Dermatology
Publisher
Wiley
Published
2009-02-18
Volume
18
Issue
3
Pages
205-211
ISSN
  • 0906-6705 (ISSN-L)
  • 1600-0625
DOI
10.1111/j.1600-0625.2008.00783.x
OpenAlex
W2070824424
Cited by
46
References
21
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 4
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Experimental Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Dermatological and Skeletal Disorders
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
photodamaged skin, extracellular matrix, elastic fibers, elastin biosynthesis, topical cream, desmosine, tropoelastin, facial skin
MeSH terms
Administration, Topical, Aged, Aged, 80 and over, Biopsy, Copper, Desmosine, Double-Blind Method, Elastin, Extracellular Matrix, Female, Humans, Malonates, Middle Aged, Ointments, Skin, Tropoelastin, Zinc, Skin Aging

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