The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
“Transcription physiology” of pigment formation in melanocytes: central role of MITF
Open accessAbstract
Please cite this paper as:“Transcription physiology” of pigment formation in melanocytes: central role of (MITF). Experimental Dermatology 2010; 19: 617–627. Abstract: Melanin production is the primary mechanism protecting human skin against the UV light‐induced damage. The polymeric compound melanin is synthesized within melanocytes in the specialized subcellular organelles, termed melanosomes, which are then transferred to surrounding keratinocytes. The genes for melanin synthesis and deposition are coordinately expressed in melanocytes. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not only for melanocyte development, proliferation and survival, but also for the expression of enzymes and structural proteins ensuring the production of melanin. MITF is a transcriptional activator of several genes which encode melanosome‐localized proteins involved both in melanin synthesis and in melanosome biogenesis and transport, including genes whose mutations are associated with human oculocutaneous and ocular forms of albinism. Here, we outline the mechanisms of transcriptional regulation of genes associated with the biosynthesis of melanin in melanocytes and melanoma cells. MITF is crucial in this process, while several other factors seem to have only an auxiliary role to play under specific circumstances.
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Cites
Melanin pigmentation in mammalian skin and its hormonal regulation
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MITF: master regulator of melanocyte development and melanoma oncogene
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The transcription factor Sox10 is a key regulator of peripheral glial development
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Cited by
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
Haq, R., Shoag, J., Andreu-Perez, P., Yokoyama, S., Edelman, H., Rowe, G. C., Frederick, D. T., Hurley, A. D., Nellore, A., Kung, A. L., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.003 · Cited by 818
Multifaceted pathways protect human skin from UV radiation
Natarajan, V. T., Ganju, P., Ramkumar, A., Grover, R., & Gokhale, R. S. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1548 · Cited by 244
Shi, Q., Zhang, W., Guo, S., Jian, Z., Li, S., Li, K., Ge, R., Dai, W., Wang, G., Gao, T., et al. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.117 · Cited by 117
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TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF
Seberg, H. E., Van Otterloo, E., Loftus, S. K., Liu, H., Bonde, G., Sompallae, R., Gildea, D. E., Santana, J. F., Manak, J. R., Pavan, W. J., et al. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006636 · Cited by 85
Metadata
- Authors
- Vachtenheim, J., & Borovanský, J.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2010-06-14
- Volume
- 19
- Issue
- 7
- Pages
- 617-627
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W1657719429
- Cited by
- 398
- References
- 128
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vachtenheim, J., & Borovanský, J. (2010). “Transcription physiology” of pigment formation in melanocytes: central role of MITF. Experimental Dermatology. https://doi.org/10.1111/j.1600-0625.2009.01053.x
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