Melanin pigmentation in mammalian skin and its hormonal regulation

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y. I., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K., & Masaki, T. (1988) · Nature · doi:10.1038/332411a0 · Cited by 10,716 · see citing works

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works

The nuclear receptor superfamily: the second decade

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works

Signal transduction by receptors with tyrosine kinase activity

Ullrich, A., & Schlessinger, J. (1990) · Cell · doi:10.1016/0092-8674(90)90801-k · Cited by 5,435 · see citing works

Dermatology in General Medicine.

(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-6-923_2 · Cited by 3,806 · see citing works

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works

Cloning and expression of a cDNA encoding an endothelin receptor

Arai, H., Hori, S., Aramori, I., Ohkubo, H., & Nakanishi, S. (1990) · Nature · doi:10.1038/348730a0 · Cited by 2,575 · see citing works

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K., & Masaki, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2863 · Cited by 2,516 · see citing works

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

Sakurai, T., Yanagisawa, M., Takuwat, Y., Miyazakit, H., Kimura, S., Goto, K., & Masaki, T. (1990) · Nature · doi:10.1038/348732a0 · Cited by 2,421 · see citing works

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J., Argos, P., & Chambon, P. (1986) · Nature · doi:10.1038/320134a0 · Cited by 2,320 · see citing works

Transposable elements: targets for early nutritional effects on epigenetic gene regulation

Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019 · see citing works

The Molecular Motor Toolbox for Intracellular Transport

Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982 · see citing works

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881 · see citing works

Influence of Season and Latitude on the Cutaneous Synthesis of Vitamin D 3 : Exposure to Winter Sunlight in Boston and Edmonton Will Not Promote Vitamin D 3 Synthesis in Human Skin*

Webb, A. R., KLINE, L., & Holick, M. F. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-373 · Cited by 1,661 · see citing works

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

Rubanyi, G. M., & Polokoff, M. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06809-7 · Cited by 1,661 · see citing works

The cloning of a family of genes that encode the melanocortin receptors

Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635 · see citing works

Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

Yarden, Y., Kuang, W.-J., Yang‐Feng, T. L., Coussens, L. M., Munemitsu, S. M., Dull, T. J., Chen, E., Schlessinger, J., Francke, U., & Ullrich, A. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02655.x · Cited by 1,573 · see citing works

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

Simoncini, T., Hafezi‐Moghadam, A., Brazil, D. P., Ley, K. F., Chin, W. W., & Liao, J. K. (2000) · Nature · doi:10.1038/35035131 · Cited by 1,437 · see citing works

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

Imagawa, M. (1987) · Cell · doi:10.1016/0092-8674(87)90152-8 · Cited by 1,384 · see citing works

Sequence and Expression of Human Estrogen Receptor Complementary DNA

Greene, G. L., Gilna, P., Waterfield, M. D., BAKER, A. J., Hort, Y., & Shine, J. (1986) · Science · doi:10.1126/science.3753802 · Cited by 1,311 · see citing works

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301 · cited 1× · see citing works

Tyrosinase: a comprehensive review of its mechanism

Sánchez‐Ferrer, Á., Rodríguez‐López, J. N., Garcı́a-Cánovas, F., & García‐Carmona, F. (1995) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(94)00204-t · Cited by 1,244 · see citing works

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling

Hall, J. M., Couse, J. F., & Korach, K. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100029200 · Cited by 1,202 · see citing works

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

Hirano, T., Ishihara, K., & Hibi, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203551 · Cited by 1,187 · see citing works

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors

Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163 · see citing works

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157 · see citing works

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096 · see citing works

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075 · see citing works

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

Hosoda, K., Hammer, R. E., Richardson, J. A., Baynash, A. G., Cheung, J. C., Giaid, A., & Yanagisawa, M. (1994) · Cell · doi:10.1016/0092-8674(94)90017-5 · Cited by 1,004 · see citing works

Variants of the melanocyte−stimulating hormone receptor gene are associated with red hair and fair skin in humans

Valverde, P., Healy, E., Jackson, I., Rees, J. L., & Thody, A. J. (1995) · Nature Genetics · doi:10.1038/ng1195-328 · Cited by 999 · see citing works

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.

Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J., Emoto, N., Hammer, R., & Yanagisawa, M. (1994) · Cell · doi:10.1016/0092-8674(94)90018-3 · Cited by 974 · see citing works

International Union of Pharmacology. XIII. Classification of Histamine Receptors

Hill, S. J., Ganellin, C. R., Timmerman, H., Schwartz, J., Shankley, N. P., Young, J. M., Schunack, W. G., Levi, R., & Haas, H. L. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01328-0 · Cited by 902 · see citing works

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

Robbins, L. S. (1993) · Cell · doi:10.1016/0092-8674(93)90572-8 · Cited by 884 · see citing works

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

Puffenberger, E. G., Hosoda, K., Washington, S. S., Nakao, K., deWit, D., Yanagisawa, M., & Chakravarti, A. (1994) · Cell · doi:10.1016/0092-8674(94)90016-7 · Cited by 883 · see citing works

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

Reppert, S. M., Godson, C., Mahle, C. D., Weaver, D. R., Slaugenhaupt, S. A., & Gusella, J. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8734 · Cited by 882 · see citing works

Tetrahydrobiopterin biosynthesis, regeneration and functions

Thöny, B., Auerbach, G., & Blau, N. (2000) · Biochemical Journal · doi:10.1042/bj3470001 · Cited by 867 · see citing works

Stem Cell Factor and Hematopoiesis

Broudy, V. C. (1997) · Blood · doi:10.1182/blood.v90.4.1345 · Cited by 862 · see citing works

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

Gantz, I., Miwa, H., Konda, Y., Shimoto, Y., Tashiro, T., Watson, S. J., DelValle, J., & Yamada, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82452-8 · Cited by 846 · see citing works

SOX10 mutations in patients with Waardenburg-Hirschsprung disease

Pingault, V., Bondurand, N., Kuhlbrodt, K., Goerich, D. E., Préhu, M., Puliti, A., Herbarth, B., Hermans‐Borgmeyer, I., Legius, E., Matthijs, G., et al. (1998) · Nature Genetics · doi:10.1038/ng0298-171 · Cited by 820 · see citing works

Cyclic AMP a Key Messenger in the Regulation of Skin Pigmentation

Buscà, R., & Ballotti, R. (2000) · Pigment Cell Research · doi:10.1034/j.1600-0749.2000.130203.x · Cited by 809 · see citing works

Molecular characterization of the mouse agouti locus

Bultman, S. J., Michaud, E. J., & Woychik, R. P. (1992) · Cell · doi:10.1016/s0092-8674(05)80067-4 · Cited by 805 · see citing works

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

Tartaglia, L. A., Weber, R. F., Figari, I. S., Reynolds, C. P., Palladino, M. A., & Goeddel, D. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9292 · Cited by 792 · see citing works

Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress

Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776 · see citing works

Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability

McGill, G. G., Horstmann, M. A., Widlund, H. R., Du, J., Motyckova, G., Nishimura, E. K., Lin, Y., Ramaswamy, S., Avery, W., Ding, H., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00762-6 · Cited by 760 · see citing works

Enzymatic control of pigmentation in mammals

Hearing, V. J., & Tsukamoto, K. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.14.1752358 · Cited by 754 · see citing works

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

Kousteni, S. (2001) · Cell · doi:10.1016/s0092-8674(02)08100-x · Cited by 749 · see citing works

Free Radicals in Biological Materials

Commoner, B., Townsend, J., & Pake, G. E. (1954) · Nature · doi:10.1038/174689a0 · Cited by 743 · see citing works

Neuroendocrinology of the Skin1

Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727 · see citing works

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

Roselli-Rehfuss, L., Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., Low, M. J., Tatro, J. B., Entwistle, M. L., Simerly, R. B., & Cone, R. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8856 · Cited by 722 · see citing works

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

Butler, A. A., Kesteson, R. A., Khong, K., Cullen, M. J., Pelleymounter, M. A., DeKoning, J., Baetscher, M., & Cone, R. D. (2000) · Endocrinology · doi:10.1210/endo.141.9.7791 · Cited by 703 · see citing works

Cloning and Functional Expression of the Human Histamine H3 Receptor

Lovenberg, T. W., Roland, B. L., Wilson, S. J., Jiang, X., Pyati, J., Huvar, A., Jackson, M. R., & Erlander, M. G. (1999) · Molecular Pharmacology · doi:10.1124/mol.55.6.1101 · Cited by 703 · see citing works

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

Tassabehji, M., Read, A., Newton, V., et al. (1992) · Nature · doi:10.1038/355635a0 · Cited by 699 · see citing works

Molecular cloning of a novel melanocortin receptor.

Gantz, I., Konda, Y., Tashiro, T., Shimoto, Y., Miwa, H., Munzert, G. M., Watson, S. J., DelValle, J., & Yamada, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53088-x · Cited by 681 · see citing works

Melanin

Riley, P. A. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00013-7 · Cited by 676 · see citing works

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.Preprint

Shutter, J. R., Graham, M., Kinsey, A. C., Scully, S. A., Lüthy, R., & Stark, K. L. (1997) · Genes & Development · doi:10.1101/gad.11.5.593 · Cited by 672 · see citing works

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

Clouthier, D. E., Hosoda, K., Richardson, J. A., Williams, S. C., Yanagisawa, H., Kuwaki, T., Kumada, M., Hammer, R. E., & Yanagisawa, M. (1998) · Development · doi:10.1242/dev.125.5.813 · Cited by 651 · see citing works

The Coat Colors of Mice

Silvers, W. K. (1979) · Springer eBooks · doi:10.1007/978-1-4612-6164-3 · Cited by 648 · see citing works

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

Besmer, P., Murphy, J. E., George, P. C., et al. (1986) · Nature · doi:10.1038/320415a0 · Cited by 645 · see citing works

BIOCHEMISTRY OF MELANIN FORMATION

Lerner, A. B., & Fitzpatrick, T. B. (1950) · Physiological Reviews · doi:10.1152/physrev.1950.30.1.91 · Cited by 630 · see citing works

THE CHEMISTRY OF MELANIN

Mason, H. S. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35614-x · Cited by 621 · see citing works

Characterization of melanin-concentrating hormone in chum salmon pituitaries

Kawauchi, H., Kawazoe, I., Tsubokawa, M., Kishida, M., & Baker, B. I. (1983) · Nature · doi:10.1038/305321a0 · Cited by 603 · see citing works

Molecular Cloning and Characterization of a Novel Type of Histamine Receptor Preferentially Expressed in Leukocytes

Oda, T., Morikawa, N., Saito, Y., Masuho, Y., & Matsumoto, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006480200 · Cited by 602 · see citing works

Melanins and Melanogenesis

Prota, G. (1992) · Elsevier eBooks · doi:10.1016/c2009-0-03380-7 · Cited by 594 · see citing works

Mammalian Tyrosinase Catalyzes Three Reactions in the Biosynthesis of Melanin

Körner, A. M., & Pawelek, J. M. (1982) · Science · doi:10.1126/science.6810464 · Cited by 594 · see citing works

Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA

Chhajlani, V., & Wikberg, J. E. S. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80820-7 · Cited by 593 · see citing works

Distribution, properties, and functional characteristics of three classes of histamine receptor.

Hill, S. J. (1990) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00039-0 · Cited by 591 · see citing works

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

Benjannet, S., Rondeau, N., Day, R. W., Chrétien, M., & Seidah, N. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3564 · Cited by 588 · see citing works

Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice

Lin, Z.-Q., Kondo, T., Ishida, Y., Takayasu, T., & Mukaida, N. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802397 · Cited by 585 · see citing works

A second tyrosinase‐related protein, TRP‐2, is a melanogenic enzyme termed DOPAchrome tautomerase.

Tsukamoto, K., Jackson, I. J., Urabe, K., Montague, P., & Hearing, V. J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05082.x · Cited by 561 · see citing works

1,25-DIHYDROXYVITAMIN D 3 AND MALIGNANT MELANOMA: THE PRESENCE OF RECEPTORS AND INHIBITION OF CELL GROWTH IN CULTURE

Colston, K. W., Colston, M. J., & Feldman, D. (1981) · Endocrinology · doi:10.1210/endo-108-3-1083 · Cited by 559 · see citing works

Pharmacological Mechanisms of Opioid Analgesics

Pasternak, G. W. (1993) · Clinical Neuropharmacology · doi:10.1097/00002826-199302000-00001 · Cited by 554 · see citing works

Growth of the Hair

Chase, H. B. (1954) · Physiological Reviews · doi:10.1152/physrev.1954.34.1.113 · Cited by 553 · see citing works

Molecular characterization of the melanin-concentrating-hormone receptor

Saito, Y., Nothacker, H., Wang, Z., Lin, S. H. S., Leslie, F. M., & Civelli, O. (1999) · Nature · doi:10.1038/22321 · Cited by 541 · see citing works

α 1 -Adrenergic Receptor Subtypes

Graham, R. M., Perez, D. M., Hwa, J., & Piascik, M. T. (1996) · Circulation Research · doi:10.1161/01.res.78.5.737 · Cited by 523 · see citing works

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

Chang, C.-S., Kokontis, J. M., & Liao, S. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7211 · Cited by 519 · see citing works

The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.

Cone, R. D., Lu, D., Koppula, S. V., Våge, D. I., Klungland, H., Boston, B. A., Chen, W., Orth, D. N., Pouton, C. W., & Kesterson, R. A. (1996) · PubMed · Cited by 518 · see citing works

Dopamine- or L-DOPA-induced neurotoxicity: The role of dopamine quinone formation and tyrosinase in a model of Parkinson’s disease

Asanuma, M., Miyazaki, I., & Ogawa, N. (2003) · Neurotoxicity Research · doi:10.1007/bf03033137 · Cited by 518 · see citing works

Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes

Bertolotto, C., Abbe, P., Hemesath, T. J., Bille, K., Fisher, D. E., Ortonne, J. P., & Ballotti, R. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.3.827 · Cited by 511 · see citing works

A Chemist's View of Melanogenesis

Ito, S. (2003) · Pigment Cell Research · doi:10.1034/j.1600-0749.2003.00037.x · Cited by 508 · see citing works

B. TYROSINE HYDROXYLASE

Udenfriend, S. (1966) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07173-x · Cited by 503 · see citing works

Neuroendocrinology of the Skin

Slominski, A. T. (2000) · Endocrine Reviews · doi:10.1210/er.21.5.457 · Cited by 503 · see citing works

Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

Chambers, J. K., Ames, R. S., Bergsma, D. J., Muir, A. I., Fitzgerald, L. R., Hervieu, G. J., Dytko, G. M., Foley, J. J., Martin, J., Liu, W., et al. (1999) · Nature · doi:10.1038/22313 · Cited by 495 · see citing works

Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides

Chen, W., Kelly, M. A., Opitz-Araya, X., Thomas, R. E., Low, M. J., & Cone, R. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80467-5 · Cited by 488 · see citing works

Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis.

Kobayashi, T., Urabe, K., Winder, A. J., Jiménez‐Cervantes, C., Imokawa, G., BREWINGTON, T., Solano, F., García-Borrón, J. C., & Hearing, V. J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06925.x · Cited by 478 · see citing works

In utero manipulation of coat color formation by a monoclonal anti‐c‐kit antibody: two distinct waves of c‐kit‐dependency during melanocyte development.

Nishikawa, S., Kusakabe, M., Yoshinaga, K., Ogawa, M., Hayashi, S., Kunisada, T., Era, T., Sakakura, T., & Nishikawa, S.-I. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07744.x · Cited by 464 · see citing works

An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome

Baldwin, C. T., Hoth, C. F., Amos, J. A., et al. (1992) · Nature · doi:10.1038/355637a0 · Cited by 460 · see citing works

Tyrosinase and related proteins in mammalian pigmentation

del Mármol, V., & Beermann, F. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00109-3 · Cited by 456 · see citing works

The melanosome: membrane dynamics in black and white

Marks, M. S., & Seabra, M. C. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096009 · Cited by 452 · see citing works

Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells✪

Raposo, G., Tenza, D., Murphy, D. M., Berson, J. F., & Marks, M. S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.809 · Cited by 451 · see citing works

Molecular Basis of Receptor/G-Protein-Coupling Selectivity

Wess, J. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00030-8 · Cited by 439 · see citing works

Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.

Kwon, B. S., Haq, A. K., Pomerantz, S. H., & Halaban, R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7473 · Cited by 438 · see citing works

TGF-β receptor signaling

Derynck, R., & Feng, X. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00017-6 · Cited by 436 · see citing works

A New Formula for Depigmenting Human Skin

Kligman, A. M. (1975) · Archives of Dermatology · doi:10.1001/archderm.1975.01630130042004 · Cited by 430 · see citing works

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.Preprint

Miller, M. W., Duhl, D. M. J., Vrieling, H., Cordes, S. P., Ollmann, M. M., Winkes, B. M., & Barsh, G. S. (1993) · Genes & Development · doi:10.1101/gad.7.3.454 · Cited by 430 · see citing works

Identification of two transcription activation units in the N-terminal domain of the human androgen receptor

Jenster, G., van der Korput, H. A. G. M., Trapman, J., & Brinkmann, A. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7341 · Cited by 419 · see citing works

Overview of Bone Morphogenetic Proteins

Wozney, J. M. (2002) · Spine · doi:10.1097/00007632-200208151-00002 · Cited by 414 · see citing works

TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor

Steel, K. P., Davidson, D. R., & Jackson, I. J. (1992) · Development · doi:10.1242/dev.115.4.1111 · Cited by 414 · see citing works

A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism

Rinchik, E. M., Bultman, S. J., Horsthemke, B., Lee, S., Strunk, K. M., Spritz, R. A., Avidano, K. M., Jong, M. T. C., & Nicholls, R. D. (1993) · Nature · doi:10.1038/361072a0 · Cited by 413 · see citing works

Cryptococcus neoformans melanin and virulence: mechanism of action

Wang, Y., Aisen, P., & Casadevall, A. (1995) · Infection and Immunity · doi:10.1128/iai.63.8.3131-3136.1995 · Cited by 411 · see citing works

Cloning and Pharmacological Characterization of a Fourth Histamine Receptor (H4) Expressed in Bone Marrow

Liu, C., Ma, X., Jiang, X., Wilson, S. J., Hofstra, C. L., Blevitt, J. M., Pyati, J., Li, X., Chai, W., Carruthers, N. I., et al. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.3.420 · Cited by 408 · see citing works

Cellular signaling by peptides of the endothelin gene family

Simonson, M. S., & Dunn, M. J. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.12.2168326 · Cited by 396 · see citing works

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

Seidah, N. G., Chrétien, M., & Day, R. W. (1994) · Biochimie · doi:10.1016/0300-9084(94)90147-3 · Cited by 396 · see citing works

New trends in photobiology

Sarna, T. (1992) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(92)85027-r · Cited by 396 · see citing works

Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism.

Giebel, L. B., & Spritz, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8696 · Cited by 389 · see citing works

Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides

Kieffer, B. L. (1995) · Cellular and Molecular Neurobiology · doi:10.1007/bf02071128 · Cited by 389 · see citing works

Human pigmentation genes: identification, structure and consequences of polymorphic variation

Sturm, R. A., Teasdale, R. D., & Box, N. F. (2001) · Gene · doi:10.1016/s0378-1119(01)00694-1 · Cited by 388 · see citing works

The coat colours of mice. A model for mammalian gene action and interaction.

Silvers, W. K. (1979) · Springer eBooks · Cited by 386 · see citing works

Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes

Imokawa, G., Yada, Y., & Miyagishi, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35817-4 · Cited by 385 · see citing works

Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.

Kurihara, Y., Kurihara, H., Oda, H., Maemura, K., Nagai, R., Ishikawa, T., & Yazaki, Y. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118033 · Cited by 384 · see citing works

Melanins and Melanogenesis

Prota, G., & Hearing, V. J. (1993) · Melanoma Research · doi:10.1097/00008390-199304000-00014 · Cited by 381 · see citing works

Early signaling pathways activated by c-Kit in hematopoietic cells

Linnekin, D. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00078-3 · Cited by 379 · see citing works

Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides

Abdel-Malek, Z., Swope, V. B., Suzuki, I., Akcali, C., Harriger, M. D., Boyce, S. T., Urabe, K., & Hearing, V. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1789 · Cited by 377 · see citing works

The kit -ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis

Besmer, P., Manova, K., Duttlinger, R., et al. (1993) · Development · doi:10.1242/dev.119.supplement.125 · Cited by 375 · see citing works

Human interleukin 1 is a cytocidal factor for several tumor cell lines.

Onozaki, K., Matsushima, K., Aggarwal, B. B., et al. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.6.3962 · Cited by 373 · see citing works

Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival

Widlund, H. R., & Fisher, D. E. (2003) · Oncogene · doi:10.1038/sj.onc.1206443 · Cited by 370 · see citing works

Mutation of the Sry-related Sox10 gene in Dominant megacolon , a mouse model for human Hirschsprung disease

Herbarth, B., Pingault, V., Bondurand, N., Kuhlbrodt, K., Hermans‐Borgmeyer, I., Puliti, A., Lemort, N., Goossens, M., & Wegner, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5161 · Cited by 369 · see citing works

Origin of Pigment Cells from the Neural Crest in the Mouse Embryo

Rawles, M. E. (1947) · Physiological Zoology · doi:10.1086/physzool.20.3.30151958 · Cited by 365 · see citing works

Mechanisms of Ultraviolet Light‐Induced Pigmentation

Gilchrest, B. A., Park, H., Eller, M. S., & Yaar, M. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb02988.x · Cited by 364 · see citing works

E-Cadherin Expression in Melanoma Cells Restores Keratinocyte-Mediated Growth Control and Down-Regulates Expression of Invasion-Related Adhesion Receptors

Hsu, M., Meier, F. E., Nesbit, M., Hsu, J.-Y., Belle, P. A. V., Elder, D. E., & Herlyn, M. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65023-7 · Cited by 362 · see citing works

The human hair follicle immune system: cellular composition and immune privilege

Christoph, T. B., Müller‐Röver, S., Audring, H., Tobin, D. J., Hermes, B., Cotsarelis, G., Rückert, R., & Paus, R. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03464.x · Cited by 361 · see citing works

The Tyrosine Hydroxylase Activity of Mammalian Tyrosinase

Pomerantz, S. H. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96973-5 · Cited by 359 · see citing works

Graying: gerontobiology of the hair follicle pigmentary unit

Tobin, D. J., & Paus, R. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00210-2 · Cited by 358 · see citing works

The pigmentary system : physiology and pathophysiology

Nordlund, J. J. (1998) · Cited by 357 · see citing works

The Immunoregulatory Mediator Macrophage Migration Inhibitory Factor (MIF) Catalyzes a Tautomerization Reaction

Rosengren, E., Bucala, R., Åman, P., Jacobsson, L., Odh, G., Metz, C. N., & Rorsman, H. (1996) · Molecular Medicine · doi:10.1007/bf03402210 · Cited by 353 · see citing works

Molecular pharmacological aspects of histamine receptors

Leurs, R., Smit, M. J., & Timmerman, H. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00006-3 · Cited by 353 · see citing works

The Human Hair Cycle11From the Department of Dermatology of the University of Pennsylvania, Philadelphia, Pa. This research was supported by U.S. Army Research Contract DA 49-007-MD-154.

Kligman, A. M. (1959) · Journal of Investigative Dermatology · doi:10.1038/jid.1959.156 · Cited by 352 · see citing works

Analysis of apoptosis during hair follicle regression (catagen)

Lindner, G., Botchkarev, V. A., Botchkareva, N. V., Ling, G., van der Veen, C., & Paus, R. (1997) · Europe PMC (PubMed Central) · Cited by 351 · see citing works

Regulation of Melanin Biosynthesis in the Human Epidermis by Tetrahydrobiopterin

Schallreuter, K. U., Wood, J. M., Pittelkow, M. R., Gütlich, M., Lemke, K. R., Rödl, W., Swanson, N. N., Hitzemann, K., & Ziegler, I. (1994) · Science · doi:10.1126/science.8128228 · Cited by 350 · see citing works

Discovery of a Novel Member of the Histamine Receptor Family

Nguyen, T., Shapiro, D. A., George, S. R., et al. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.3.427 · Cited by 349 · see citing works

Molecular basis of albinism: Mutations and polymorphisms of pigmentation genes associated with albinism

Oetting, W. S., & King, R. A. (1999) · Human Mutation · doi:10.1002/(sici)1098-1004(1999)13:2 · Cited by 349 · see citing works

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

Schauer, E., Trautinger, F., Köck, A., Schwarz, A., Bhardwaj, R. S., Simon, M. M., Ansel, J. C., Schwarz, T., & Luger, T. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117224 · Cited by 347 · see citing works

Tissue Distribution of Estrogen Receptors Alpha (ER- ) and Beta (ER- ) mRNA in the Midgestational Human Fetus

Brandenberger, A. W., Tee, M. K., Lee, J. Y., Chao, V. A., & Jaffe, R. B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4400 · Cited by 335 · see citing works

Molecular Cloning of a Novel Human Melanocortin Receptor

Chhajlani, V., Muceniece, R., & Wikberg, J. E. S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2125 · Cited by 333 · see citing works

Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B

Chakraborty, A. K., Funasaka, Y., Slominski, A., Ermak, G., Hwang, J., Pawelek, J. M., & Ichihashi, M. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(96)00063-8 · Cited by 333 · see citing works

Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis

Suzuki, I., Cone, R. D., Im, S., Nordlund, J. J., & ABDEL‐MALEK, Z. A. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612494 · Cited by 332 · see citing works

Effect of Alpha- and Beta-Melanocyte Stimulating Hormones on the Skin Colour of Man

Lerner, A. B., & McGuire, J. S. (1961) · Nature · doi:10.1038/189176a0 · Cited by 326 · see citing works

An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston

Webb, A. R., Pilbeam, C. C., Hanafin, N. M., & Holick, M. F. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.6.1075 · Cited by 318 · see citing works

Different cis -Acting Elements Are Involved in the Regulation of TRP1 and TRP2 Promoter Activities by Cyclic AMP: Pivotal Role of M Boxes (GTCATGTGCT) and of Microphthalmia

Bertolotto, C., Buscà, R., Abbe, P., Bille, K., Aberdam, É., Ortonne, J. P., & Ballotti, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.694 · Cited by 317 · see citing works

A second tyrosinase‐related protein, TRP‐2, maps to and is mutated at the mouse slaty locus.

Jackson, I. J., Chambers, D. M., Tsukamoto, K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., & Hearing, V. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05083.x · Cited by 316 · see citing works

Cloning, Expression, and Pharmacological Characterization of a Novel Human Histamine Receptor

Zhu, Y., Michalovich, D., Wu, H.-L., Tan, K. B., Dytko, G. M., Mannan, I. J., Boyce, R. W., Alston, J. T., Tierney, L. A., Li, X., et al. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.3.434 · Cited by 312 · see citing works

Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.

Ueda, T., Mawji, N. R., Bruchovsky, N., & Sadar, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203313200 · Cited by 311 · see citing works

Mechanisms of androgen receptor activation and function

Brinkmann, A. O., Blok, L. J., de Ruiter, P. E., Doesburg, P., Steketee, K., Berrevoets, C., & Trapman, J. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00049-7 · Cited by 308 · see citing works

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

Brannan, C. I., Lyman, S. D., Williams, D. E., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4671 · Cited by 303 · see citing works

The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma

Valverde, P. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.10.1663 · Cited by 303 · see citing works

Racial Pigmentation and the Cutaneous Synthesis of Vitamin D

Matsuoka, L. Y. (1991) · Archives of Dermatology · doi:10.1001/archderm.1991.04510010104011 · Cited by 302 · see citing works

Endothelins: multifunctional renal peptides.

Simonson, M. S. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.375 · Cited by 300 · see citing works

The Rat Melanin-Concentrating Hormone Messenger Ribonucleic Acid Encodes Multiple Putative Neuropeptides Coexpressed in the Dorsolateral Hypothalamus*

Nahon, J., Presse, F., Bittencourt, J. C., Sawchenko, P. E., & Vale, W. (1989) · Endocrinology · doi:10.1210/endo-125-4-2056 · Cited by 299 · see citing works

Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci

Motro, B., van der Kooy, D., Rossant, J., Reith, A. D., & Bernstein, A. (1991) · Development · doi:10.1242/dev.113.4.1207 · Cited by 296 · see citing works

Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.

Hosoi, J., Abe, E., Suda, T., & Kuroki, T. (1985) · PubMed · Cited by 295 · see citing works

Biologic functions of the IFN‐γ receptors

Tau, G. Z., & Rothman, P. B. (1999) · Allergy · doi:10.1034/j.1398-9995.1999.00099.x · Cited by 291 · see citing works

THE PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE SKIN

Jarrett, A. (1973) · The Lancet · doi:10.1016/s0140-6736(73)92308-8 · Cited by 288 · see citing works

Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway

Wehrle‐Haller, B., & Weston, J. A. (1995) · Development · doi:10.1242/dev.121.3.731 · Cited by 285 · see citing works

Serotoninergic and melatoninergic systems are fully expressed in human skin

Slominski, A. T., Pisarchik, A. V., Semak, I. V., Sweatman, T. W., Wortsman, J., Szczesniewski, A., Slugocki, G., McNulty, J. A., Kauser, S., Tobin, D. J., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0952fje · Cited by 285 · see citing works

MOLECULAR AND DEVELOPMENTAL GENETICS OF MOUSE COAT COLOR

Jackson, I. J. (1994) · Annual Review of Genetics · doi:10.1146/annurev.ge.28.120194.001201 · Cited by 277 · see citing works

Advances in Biology of Skin

Hasegawa, J. (1961) · Archives of Dermatology · doi:10.1001/archderm.1961.01580130183037 · Cited by 277 · see citing works

A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1).

Jiménez‐Cervantes, C., Solano, F., Kobayashi, T., Urabe, K., Hearing, V. J., Lozano, J. A., & García-Borrón, J. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32408-0 · Cited by 274 · see citing works

Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis

Buznikov, G. A., Lambert, H. W., & Lauder, J. M. (2001) · Cell and Tissue Research · doi:10.1007/s004410100408 · Cited by 274 · see citing works

Melanosomes Are Specialized Members of the Lysosomal Lineage of Organelles

Orlow, S. J. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12312291 · Cited by 273 · see citing works

Functional analysis of alternatively spliced tyrosinase gene transcripts.

Müller, G., Ruppert, S., Schmid, E., & Schütz, G. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03126.x · Cited by 271 · see citing works

Human Keratinocytes Synthesize, Secrete, and Degrade Acetylcholine

Grando, S. A., Kist, D. A., Qi, M., & Dahl, M. V. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12358588 · Cited by 271 · see citing works

Effects of endothelins on signal transduction and proliferation in human melanocytes.

Yada, Y., Higuchi, K., & Imokawa, G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55277-7 · Cited by 270 · see citing works

Rapid signalling by androgen receptor in prostate cancer cells

Peterziel, H., Mink, S., Schonert, A., Becker, M., Klocker, H., & Cato, A. C. B. (1999) · Oncogene · doi:10.1038/sj.onc.1203032 · Cited by 269 · see citing works

Interleukins 1α and 6 and Tumor Necrosis Factor-α Are Paracrine Inhibitors of Human Melanocyte Proliferation and Melanogenesis

Swope, V. B., ABDEL‐MALEK, Z. A., Kassem, L. M., & Nordlund, J. J. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12460991 · Cited by 269 · see citing works

Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo

Costa, J. J., Demetri, G. D., Harrist, T. J., Dvorak, A. M., Hayes, D. F., Merica, E. A., Menchaca, D. M., Gringeri, A. J., Schwartz, L. B., & Galli, S. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2681 · Cited by 268 · see citing works

Role of Tyrosinase as the Determinant of Pigmentation in Cultured Human Melanocytes

Iozumi, K., Hoganson, G. E., Pennella, R., Everett, M. A., & Fuller, B. B. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12476630 · Cited by 267 · see citing works

Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis

Longley, B. J., Morganroth, G. S., Tyrrell, L., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305063281803 · Cited by 266 · see citing works

Tumor vascularity and tryptase‐positive mast cells correlate with a poor prognosis in melanoma

Ribatti, D., Ennas, M. G., Vacca, A., et al. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01152.x · Cited by 263 · see citing works

OPIOID RECEPTOR SIGNALLING MECHANISMS

Connor, M. A., & Christie, M. J. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03049.x · Cited by 259 · see citing works

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells

Halaban, R., Cheng, E., Zhang, Y., Moellmann, G. E., Hanlon, D. J., Michalak, M., Setaluri, V., & Hebert, D. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6210 · Cited by 257 · see citing works

Loss of AP‐2 results in downregulation of c‐KIT and enhancement of melanoma tumorigenicity and metastasis

Huang, S., Jean, D., Luca, M., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4358 · Cited by 257 · see citing works

Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I).

Hoth, C. F., Milunsky, A., Lipsky, N. R., Sheffer, R. N., Clarren, S. K., & Baldwin, C. T. (1993) · PubMed · Cited by 250 · see citing works

The biological actions of estrogens on skin

Thornton, M. J. (2002) · Experimental Dermatology · doi:10.1034/j.1600-0625.2002.110601.x · Cited by 248 · see citing works

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

Chen, A. S., Metzger, J. M., Trumbauer, M. E., Guan, X.-M., Yu, H., Frazier, E. G., Marsh, D. J., Forrest, M. J., Gopal-Truter, S., Fisher, J. K., et al. (2000) · Transgenic Research · doi:10.1023/a:1008983615045 · Cited by 247 · see citing works

Clinical chemistry of serotonin and metabolites

Kema, I. P., de Vries, E. G. E., & Muskiet, F. A. J. (2000) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)00341-8 · Cited by 246 · see citing works

SCF/c‐kit signaling is required for cyclic regeneration of the hair pigmentation unit

Botchkareva, N. V., Khlgatian, M. K., Longley, B. J., Botchkarev, V. A., & Gilchrest, B. A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0368com · Cited by 246 · see citing works

Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death

Sawada, H., Ibi, M., Kihara, T., Urushitani, M., Akaike, A., & Shimohama, S. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981201)54:5 · Cited by 246 · see citing works

A model for melanosome biogenesis based on the purification and analysis of early melanosomes

Kushimoto, T., Basrur, V., Valencia, J. C., Matsunaga, J., Vieira, W. D., Ferrans, V. J., Müller, J., Appella, E., & Hearing, V. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191184798 · Cited by 244 · see citing works

Biological Functions of Keratinocyte Cholinergic Receptors

Grando, S. A. (1997) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.1997.10 · Cited by 243 · see citing works

Melanosomal pH Controls Rate of Melanogenesis, Eumelanin/Phaeomelanin Ratio and Melanosome Maturation in Melanocytes and Melanoma Cells

Ancāns, J., Tobin, D. J., Hoogduijn, M. J., Smit, N. P. M., Wakamatsu, K., & Thody, A. J. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5251 · Cited by 242 · see citing works

New regulators of melanin biosynthesis and the autodestruction of melanoma cells

Pawelek, J. M., Körner, A. M., Bergstrom, A. R., & Bologna, J. (1980) · Nature · doi:10.1038/286617a0 · Cited by 242 · see citing works

Williams Syndrome: Use of Chromosomal Microdeletions as a Tool to Dissect Cognitive and Physical Phenotypes

Tassabehji, M., Metcalfe, K., Karmiloff‐Smith, A., Carette, M. J. M., Grant, J., Dennis, N. R., Reardon, W., Splitt, M. P., Read, A., & Donnai, D. (1999) · The American Journal of Human Genetics · doi:10.1086/302214 · Cited by 241 · see citing works

Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R

Sailer, A. W., Sano, H., Zeng, Z., McDonald, T. P., Pan, J., Pong, S., Feighner, S. D., Tan, C. P., Fukami, T., Iwaasa, H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121170598 · Cited by 239 · see citing works

Inhibition of Melanosome Transfer Results in Skin Lightening1

Seiberg, M., Paine, C., Sharlow, E., Eisinger, M., Shapiro, S. S., Andrade-Gordon, P., & Costanzo, M. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00035.x · Cited by 238 · see citing works

Endothelin-1 as a New Melanogen: Coordinated Expression of Its Gene and the Tyrosinase Gene in UVB-Exposed Human Epidermis

Imokawa, G., Miyagishi, M., & Yada, Y. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12312500 · Cited by 238 · see citing works

Functional activity of serotoninergic and melatoninergic systems expressed in the skin

Slominski, A. T., Pisarchik, A. V., Zbytek, B., Tobin, D. J., Kauser, S., & Wortsman, J. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10287 · Cited by 234 · see citing works

α-melanocyte stimulating hormone and its analogue nle4dphe7α-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes

Hunt, G., Todd, C., Cresswell, J. E., & Thody, A. J. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.1.205 · Cited by 234 · see citing works

Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

Yamashita, M., Fukui, H., Sugama, K., Horio, Y., Ito, S., Mizuguchi, H., & Wada, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11515 · Cited by 233 · see citing works

Topical tretinoin for treatment of photodamaged skin. A multicenter study

Weinstein, G. D. (1991) · Archives of Dermatology · doi:10.1001/archderm.127.5.659 · Cited by 232 · see citing works

Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation

Buscà, R., Bertolotto, C., Ortonne, J. P., & Ballotti, R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31824 · Cited by 231 · see citing works

Characterization of Melanin-Concentrating Hormone from Rat Hypothalamus*

Vaughan, J. M., Fischer, W. H., Hoeger, C. A., Rivier, J., & Vale, W. (1989) · Endocrinology · doi:10.1210/endo-125-3-1660 · Cited by 231 · see citing works

The Menkes copper transporter is required for the activation of tyrosinase

Petris, M. J. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.19.2845 · Cited by 231 · see citing works

The Mouse Pink-Eyed Dilution Gene: Association with Human Prader-Willi and Angelman Syndromes

Gardner, J. M., Nakatsu, Y., Gondo, Y., Lee, S., Lyon, M. F., King, R. A., & Brilliant, M. H. (1992) · Science · doi:10.1126/science.257.5073.1121 · Cited by 230 · see citing works

Leukotrienes and Other Lipoxygenase Products in the Pathogenesis and Therapy of Psoriasis and Other Dermatoses

Voorhees, J. J. (1983) · Archives of Dermatology · doi:10.1001/archderm.1983.01650310003001 · Cited by 230 · see citing works

Microphthalmia‐associated transcription factor interacts with LEF‐1, a mediator of Wnt signaling

Yasumoto, K., Takeda, K., Saito, H., Watanabe, K., Takahashi, K., & Shibahara, S. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2703 · Cited by 228 · see citing works

The Effects of Oral Melatonin on Skin Color and on the Release of Pituitary Hormones

Nordlund, J. J., & Lerner, A. B. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-4-768 · Cited by 227 · see citing works

Molecular Cloning and Functional Characterization of MCH2, a Novel Human MCH Receptor

Hill, J., Duckworth, M. D., Murdock, P. R., Rennie, G. I., Sabido-David, C., Ames, R. S., Szekeres, P. G., Wilson, S., Bergsma, D. J., Gloger, I., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102068200 · Cited by 225 · see citing works

Melanocyte‐Stimulating Properties of Arachidonic Acid Metabolites: Possible Role in Postinflammatory Pigmentation

Tomita, Y., Maeda, K., & Tagami, H. (1992) · Pigment Cell Research · doi:10.1111/j.1600-0749.1992.tb00562.x · Cited by 223 · see citing works

Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2

Tassabehji, M., Read, A., Newton, V., Patton, M. A., Gruß, P., Harris, R., & Strachan, T. (1993) · Nature Genetics · doi:10.1038/ng0193-26 · Cited by 222 · see citing works

Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon.

Houghton, A. N., Thomson, T. M., Gross, D., Oettgen, H. F., & Old, L. J. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.1.255 · Cited by 221 · see citing works

Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus

Ludwig, D. S., Mountjoy, K. G., Tatro, J. B., Gillette, J. A., Frederich, R. C., Flier, J. S., & Maratos–Flier, E. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.4.e627 · Cited by 220 · see citing works

UV radiation and the skin

D'Orazio, J., Jarrett, S., Amaro-Ortiz, A., & Scott, T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612222 · Cited by 1,984 · see citing works

Melanocyte biology and skin pigmentation

Lin, J. Y., & Fisher, D. E. (2007) · Nature · doi:10.1038/nature05660 · Cited by 1,379 · see citing works

Hair follicle pigmentation

Slominski, A., Wortsman, J., Plonka, P. M., Schallreuter, K. U., Paus, R., & Tobin, D. J. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23528.x · Cited by 532 · see citing works

Untitled work

Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works

How UV Light Touches the Brain and Endocrine System Through Skin, and Why

Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P., & Paus, R. (2018) · Endocrinology · doi:10.1210/en.2017-03230 · Cited by 452 · see citing works

The cutaneous serotoninergic/melatoninergic system: securing a place under the sun

Slominski, A., Wortsman, J., & Tobin, D. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2079rev · Cited by 402 · see citing works

Key role of CRF in the skin stress response system

Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works

Steroidogenesis in the skin: Implications for local immune functions

Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works

Regulation of melanogenesis – controversies and new concepts

Schallreuter, K. U., Kothari, S., Chavan, B., & Spencer, J. D. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00675.x · Cited by 352 · see citing works

Skin Senescence: Mechanisms and Impact on Whole-Body Aging

Franco, A. C., Aveleira, C., & Cavadas, C. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.12.003 · Cited by 321 · see citing works

Clinical and Biological Characterization of Skin Pigmentation Diversity and Its Consequences on UV Impact

Del Bino, S., Duval, C., & Bernerd, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092668 · Cited by 315 · see citing works

Differential expression of HPA axis homolog in the skin

Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.012 · Cited by 279 · see citing works

Cutaneous hypothalamic–pituitary–adrenal axis homolog: regulation by ultraviolet radiation

Skobowiat, C., Dowdy, J. C., Sayre, R. M., Tuckey, R. C., & Slominski, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00217.2011 · Cited by 269 · see citing works

Regulation of human skin pigmentation and responses to ultraviolet radiation

Miyamura, Y., Coelho, S. G., Wolber, R., Miller, S. A., Wakamatsu, K., Zmudzka, B. Z., Ito, S., Smuda, C., Passeron, T., Choi, W., et al. (2007) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00358.x · Cited by 250 · see citing works

Signatures of positive selection in genes associated with human skin pigmentation as revealed from analyses of single nucleotide polymorphisms

Lao, O., de Gruijter, J. M., van Duijn, K., Navarro, A., & Kayser, M. (2007) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2006.00341.x · Cited by 231 · see citing works

Arbutin as a Skin Depigmenting Agent with Antimelanogenic and Antioxidant Properties

Boo, Y. C. (2021) · Antioxidants · doi:10.3390/antiox10071129 · Cited by 241 · see citing works

<scp>MC</scp>1R, Eumelanin and Pheomelanin: Their Role in Determining the Susceptibility to Skin Cancer

Nasti, T. H., & Timares, L. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12335 · Cited by 217 · see citing works

CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH

Slominski, A., Zbytek, B., Szczesniewski, A., Semak, I., Kaminski, J., Sweatman, T., & Wortsman, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00519.2004 · Cited by 211 · see citing works

<scp>MC</scp>1R, the c<scp>AMP</scp> pathway, and the response to solar <scp>UV</scp>: extending the horizon beyond pigmentation

García‐Borrón, J. C., Abdel‐Malek, Z., & Jiménez‐Cervantes, C. (2014) · Pigment Cell &amp; Melanoma Research · doi:10.1111/pcmr.12257 · Cited by 187 · see citing works

Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma

Brożyna, A. A., Jóźwicki, W., Carlson, J. A., & Slominski, A. T. (2013) · Human Pathology · doi:10.1016/j.humpath.2013.02.022 · Cited by 175 · see citing works

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions

Slominski, A. T., Kim, T.-K., Li, W., Yi, A.-K., Postlethwaite, A., & Tuckey, R. C. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.10.012 · Cited by 170 · see citing works

Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways

Janjetovic, Z., Jarrett, S. G., Lee, E. F., Duprey, C., Reiter, R. J., & Slominski, A. T. (2017) · Scientific Reports · doi:10.1038/s41598-017-01305-2 · Cited by 163 · see citing works

Corticotropin releasing hormone and the skin

Slominski, A. (2006) · Frontiers in bioscience · doi:10.2741/1966 · Cited by 157 · see citing works

Skin whitening cosmetics: feedback and challenges in the development of natural skin lighteners

Burger, P., Landreau, A., Azoulay, S., Michel, T., & Fernandez, X. (2016) · Cosmetics · doi:10.3390/cosmetics3040036 · Cited by 152 · see citing works

Protective Effects of Novel Derivatives of Vitamin D3 and Lumisterol Against UVB-Induced Damage in Human Keratinocytes Involve Activation of Nrf2 and P53 Defense Mechanisms

Chaiprasongsuk, A., Janjetovic, Z., Kim, T.-K., Jarrett, S. G., D'Orazio, J. A., Holick, M. F., Tang, E. K. Y., Tuckey, R. C., Panich, U., Li, W., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101206 · Cited by 146 · see citing works

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

Slominski, A. T., Brożyna, A. A., Zmijewski, M. A., Jóźwicki, W., Jetten, A. M., Mason, R. S., Tuckey, R. C., & Elmets, C. A. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.3 · Cited by 136 · see citing works

The genetic and evolutionary basis of colour variation in vertebrates

Hofreiter, M., & Schöneberg, T. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0333-7 · Cited by 128 · see citing works

Melanin transfer in human skin cells is mediated by filopodia—A model for homotypic and heterotypic lysosome-related organelle transfer

Singh, S. K., Kurfurst, R., Nizard, C., Schnebert, S., Perrier, E., & Tobin, D. J. (2010) · The FASEB Journal · doi:10.1096/fj.10-159046 · Cited by 119 · see citing works

Expression of vitamin D receptor decreases during progression of pigmented skin lesions

Brożyna, A. A., Jozwicki, W., Janjetovic, Z., & Slominski, A. T. (2011) · Human Pathology · doi:10.1016/j.humpath.2010.09.014 · Cited by 120 · see citing works

Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications

Boo, Y. C. (2019) · Antioxidants · doi:10.3390/antiox8090332 · Cited by 119 · see citing works

Skin as an endocrine organ: implications for its function

Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.04.004 · Cited by 116 · see citing works

Key Regulatory Role of Dermal Fibroblasts in Pigmentation as Demonstrated Using a Reconstructed Skin Model: Impact of Photo-Aging

Duval, C., Cohen, C., Chagnoleau, C., Flouret, V., Bourreau, E., & Bernerd, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114182 · Cited by 114 · see citing works

Stress-linked cortisol concentrations in hair: what we know and what we need to know

Sharpley, C. F., McFarlane, J. R., & Slominski, A. (2012) · revneuro · doi:10.1515/rns.2011.058 · Cited by 92 · see citing works

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives

Janjetovic, Z., Brozyna, A. A., Tuckey, R. C., Kim, T.-K., Nguyen, M. N., Jozwicki, W., Pfeffer, S. R., Pfeffer, L. M., & Slominski, A. T. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.458 · Cited by 91 · see citing works

The pleiotropic roles of autophagy regulators in melanogenesis

Ho, H., & Ganesan, A. K. (2011) · Pigment Cell &amp; Melanoma Research · doi:10.1111/j.1755-148x.2011.00889.x · Cited by 88 · see citing works

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

Slominski, A. T., Kim, T.-K., Hobrath, J. V., Janjetovic, Z., Oak, A. S. W., Postlethwaite, A., Lin, Z., Li, W., Takeda, Y., Jetten, A. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10202-7 · Cited by 82 · see citing works

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology · doi:10.1111/exd.12376 · Cited by 79 · see citing works

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation

Slominski, A. T., Janjetovic, Z., Kim, T.-K., Wasilewski, P., Rosas, S., Hanna, S., Sayre, R. M., Dowdy, J. C., Li, W., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.01.014 · Cited by 77 · see citing works

Novel vitamin D photoproducts and their precursors in the skin

Slominski, A., Kim, T.-K., Zmijewski, M. A., Janjetovic, Z., Li, W., Chen, J., Kusniatsova, E. I., Semak, I., Postlethwaite, A., Miller, D. D., et al. (2013) · Dermato-Endocrinology · doi:10.4161/derm.23938 · Cited by 76 · see citing works

On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders

Slominski, A. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08958.x · Cited by 74 · see citing works

Expression of the vitamin D–activating enzyme 1α-hydroxylase (CYP27B1) decreases during melanoma progression

Brożyna, A. A., Jóźwicki, W., Janjetovic, Z., & Slominski, A. T. (2013) · Human Pathology · doi:10.1016/j.humpath.2012.03.031 · Cited by 70 · see citing works

Autism prevalence in the united states with respect to solar UV-B doses: An ecological study

Grant, W. B., & Cannell, J. J. (2013) · Dermato-Endocrinology · doi:10.4161/derm.22942 · Cited by 67 · see citing works

Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL

Burgoyne, T., O'Connor, M. N., Seabra, M. C., Cutler, D. F., & Futter, C. E. (2015) · Journal of Cell Science · doi:10.1242/jcs.164400 · Cited by 68 · see citing works

Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes

Zbytek, B., Wortsman, J., & Slominski, A. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0116 · Cited by 60 · see citing works

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis

Hyter, S., Coleman, D. J., Ganguli‐Indra, G., Merrill, G. F., Ma, S., Yanagisawa, M., & Indra, A. K. (2013) · Pigment Cell &amp; Melanoma Research · doi:10.1111/pcmr.12063 · Cited by 61 · see citing works

Melanin distribution from the dermal–epidermal junction to the stratum corneum: non-invasive in vivo assessment by fluorescence and Raman microspectroscopy

Yakimov, B. P., Shirshin, E. A., Schleusener, J., Allenova, A. S., Fadeev, V. V., & Darvin, M. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-71220-6 · Cited by 56 · see citing works

Endometriosis risk in relation to naevi, freckles and skin sensitivity to sun exposure: the French E3N cohort

Kvaskoff, M., Mesrine, S., Clavel-Chapelon, F., & Boutron-Ruault, M.-C. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp175 · Cited by 53 · see citing works

Progress in melanoma modelling in vitro

Marconi, A., Quadri, M., Saltari, A., & Pincelli, C. (2018) · Experimental Dermatology · doi:10.1111/exd.13670 · Cited by 51 · see citing works

Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity

Zmijewski, M. A., Li, W., Chen, J., Kim, T.-K., Zjawiony, J. K., Sweatman, T. W., Miller, D. D., & Slominski, A. T. (2011) · Steroids · doi:10.1016/j.steroids.2010.10.009 · Cited by 51 · see citing works

The eumelanin intermediate 5,6–dihydroxyindole–2–carboxylic acid is a messenger in the cross–talk among epidermal cells

Kovacs, D., Flori, E., Maresca, V., Ottaviani, M., Aspite, N., Dell'Anna, M. L., Panzella, L., Napolitano, A., Picardo, M., & d'Ischia, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.457 · Cited by 50 · see citing works

Advances in Melanocyte Basic Science Research

Schallreuter, K. U. (2007) · Dermatologic Clinics · doi:10.1016/j.det.2007.04.010 · Cited by 46 · see citing works

Shedding light on the variability of optical skin properties: finding a path towards more accurate prediction of light propagation in human cutaneous compartments

Mignon, C., Tobin, D. J., Zeitouny, M., & Uzunbajakava, N. E. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.000852 · Cited by 43 · see citing works

Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses

Skobowiat, C., Nejati, R., Lu, L., Williams, R. W., & Slominski, A. T. (2013) · Gene · doi:10.1016/j.gene.2013.08.035 · Cited by 42 · see citing works

E-cadherin mediates ultraviolet radiation- and calcium-induced melanin transfer in human skin cells

Singh, S. K., Baker, R., Sikkink, S. K., Nizard, C., Schnebert, S., Kurfurst, R., & Tobin, D. J. (2017) · Experimental Dermatology · doi:10.1111/exd.13395 · Cited by 37 · see citing works

An explanation for the mysterious distribution of melanin in human skin: A rare example of asymmetric (melanin) organelle distribution during mitosis of basal layer progenitor keratinocytes

Joly-Tonetti, N., Wibawa, J. I. D., Bell, M., & Tobin, D. J. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16926 · Cited by 36 · see citing works

UVB-Induced Melanocyte Proliferation in Neonatal Mice Driven by CCR2-Independent Recruitment of Ly6clowMHCIIhi Macrophages

Handoko, H. Y., Rodero, M. P., Boyle, G. M., Ferguson, B., Engwerda, C., Hill, G., Konrad Muller, H., Khosrotehrani, K., & Walker, G. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.9 · Cited by 36 · see citing works

Sublethal consequences of ultraviolet radiation exposure on vertebrates: Synthesis through meta‐analysis

Downie, A. T., Wu, N. C., Cramp, R. L., & Franklin, C. E. (2023) · Global Change Biology · doi:10.1111/gcb.16848 · Cited by 34 · see citing works

Vitamins and Melanoma

Russo, I., Caroppo, F., & Alaibac, M. (2015) · Cancers · doi:10.3390/cancers7030841 · Cited by 29 · see citing works

Are some melanomas caused by artificial light?

Kvaskoff, M., & Weinstein, P. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.03.010 · Cited by 25 · see citing works

Melanocytes from dark and light skin respond differently after ultraviolet B irradiation: effect of keratinocyte-conditioned medium

López, S., Alonso, S., García de Galdeano, A., & Smith‐Zubiaga, I. (2015) · Photodermatology, Photoimmunology &amp; Photomedicine · doi:10.1111/phpp.12169 · Cited by 21 · see citing works

A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis

Wood, J. M., & Schallreuter, K. U. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00754.x · Cited by 20 · see citing works

Molecular Characterization of Coat Color Gene in Sahiwal versus Karan Fries Bovine

Goud, T. S., Upadhyay, R. C., Pichili, V. B. R., Onteru, S. K., & Chadipiralla, K. (2021) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-021-00117-2 · Cited by 11 · see citing works

Effects of CE Ferulic® Combined with Microneedling in the Treatment of Pigmentary Disorders: A Monocentric, Split Face, Comparative Study

Proietti, I., Guida, S., Dybala, A., Spagnoli, A., & Potenza, C. (2024) · Cosmetics · doi:10.3390/cosmetics11030101 · Cited by 5 · see citing works

Melatoninergic System in the Skin

Slominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., & Steketee, J. D. (2012) · Advances in Anatomy, Embryology and Cell Biology · doi:10.1007/978-3-642-19683-6_3 · Cited by 4 · see citing works

Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults

de Boer, F., Kezic, S., van der Lelie, G., Motazedi, E., Rustemeyer, T., van Dijk, A., Almasian, M., Jakasa, I., & van der Molen, H. F. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.01.024 · Cited by 4 · see citing works

Targeting Melanogenesis with Postbiotics: An Integrated Zebrafish-Based Assessment of Lactobacillus salivarius BGHO-1 and Lactobacillus paracasei BGSJ2-8

Katona, G., Jovanovic Ljeskovic, N., Strahinic, I., Stanisavljevic, N., Vojvodic, S., Djuris, J., & Pavic, A. (2025) · Molecules · doi:10.3390/molecules30204134 · Cited by 1 · see citing works

The Melanocortin 1 Receptor and the UV Response of Human Melanocytes—A Shift in Paradigm^†

Abdel‐Malek, Z. A., Knittel, J., Kadekaro, A. L., Swope, V. B., & Starner, R. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2008.00294.x · Cited by 111 · see citing works

Melanocortin 1 Receptor (MC1R) as a Global Regulator of Cutaneous UV Responses: Molecular Interactions and Opportunities for Melanoma Prevention

Horrell, E. M. W., & D'Orazio, J. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-43157-4_7 · Cited by 1 · see citing works

The Melanocortin‐1 Receptor is a Key Regulator of Human Cutaneous Pigmentation

ABDEL‐MALEK, Z. A., Scott, M., Suzuki, I., Tada, A., Im, S., Lamoreux, L., Ito, S., Barsh, G. S., & Hearing, V. J. (2000) · Pigment Cell Research · doi:10.1034/j.1600-0749.13.s8.28.x · Cited by 136 · see citing works

Humanmelanocortin 1 receptorvariants, receptor function and melanocyte response to UV radiation

Scott, M., Wakamatsu, K., Ito, S., Kadekaro, A. L., Kobayashi, N., Groden, J. L., Kavanagh, R. J., Takakuwa, T., Virador, V. M., Hearing, V. J., et al. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.11.2349 · Cited by 203 · see citing works

Regulation of eumelanin/pheomelanin synthesis and visible pigmentation in melanocytes by ligands of the melanocortin 1 receptor

Pape, E. L., Wakamatsu, K., Ito, S., Wolber, R., & Hearing, V. J. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2008.00479.x · Cited by 89 · see citing works