The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Determinant Selection and Macrophage Function in Genetic Control of the Immune Response
Abstract
The immune response to insulin, in both mouse and guinea pig, is under control of H-linked immune response genes. When immunized with either pork or beef insulin in CFA, both strain 2 and 13 guinea pigs respond by antigen-specific lymphocyte proliferation and synthesis of specific antibody. The specificities of the elicited antibodies and indistinguishable between these inbred strains. By constrast, strain 2 T cells recognized a distinct region of the A chain alpha loop consisting of amino acid residues 8, 9 and 10, while strain 13 T cells see an as yet undefined region of the B chain. H2b (A chain alpha loop responder) and H2d (B chain responder) mice similarly discriminate which areas of the molecule are recognized by their T lymphocytes. The function of the Ir gene in both the guinea pig and mouse appears to be an intramolecular selection of discrete regions within the antigen for recognition by the T cell. The data presented suggest that this function operates at the level of the macrophage.
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Citations
Cites
FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES
Rosenthal, A. S., & Shevach, E. M. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.138.5.1194 · Cited by 1,036
Self-citationInsulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by
Blundell, T., Dodson, G., Hodgkin, D., & Mercola, D. (1972) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60143-6 · Cited by 836
FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES
Shevach, E. M., & Rosenthal, A. S. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.138.5.1213 · Cited by 605
Self-citationThymus and Antigen‐Reactive Cells
Miller, J. F. A. P., & Mitchell, G. F. (1969) · Immunological Reviews · doi:10.1111/j.1600-065x.1969.tb00135.x · Cited by 337
Hersh, E. M., & Harris, J. E. (1968) · The Journal of Immunology · doi:10.4049/jimmunol.100.6.1184 · Cited by 259
Metschnikoff, E. (1884) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf02361555 · Cited by 211
Waldron, J. A., Horn, R. G., & Rosenthal, A. S. (1973) · The Journal of Immunology · doi:10.4049/jimmunol.111.1.58 · Cited by 185
Self-citation
Cited by
Endocytosis and the recycling of plasma membrane.
Steinman, R. M., Mellman, I. S., Muller, W. A., & Cohn, Z. A. (1983) · The Journal of cell biology · doi:10.1083/jcb.96.1.1 · Cited by 1,450
The Biochemistry and Cell Biology of Antigen Processing and Presentation
Germain, R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.immunol.11.1.403 · Cited by 1,020
The T Lymphocyte In Experimental Allergic Encephalomyelitis
Zamvil, S. (1990) · Annual Review of Immunology · doi:10.1146/annurev.immunol.8.1.579 · Cited by 1,009
The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition
Kronenberg, M. (1986) · Annual Review of Immunology · doi:10.1146/annurev.immunol.4.1.529 · Cited by 765
Role of MHC Gene Products in Immune Regulation
Benacerraf, B. (1981) · Science · doi:10.1126/science.6165083 · Cited by 696
Metadata
- Authors
- Rosenthal, A. S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 1978-08
- Volume
- 40
- Issue
- 1
- Pages
- 136-152
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2090810855
- Cited by
- 381
- References
- 7
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
