Cited by 600Advanced Glycation End Products researchImmune Response and InflammationBiomarkers in Disease Mechanisms

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High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity

Bianchi, Marco E., Manfredi, Angelo A.·2007·Immunological Reviews

DOI 10.1111/j.1600-065x.2007.00574.x

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Abstract

Summary: Tissue damage occurs often in the life of mammals and is usually repaired. Dying cells are swiftly phagocytosed, but before disappearing, they alert surrounding cells to activate homeostatic programs. They release signals that recruit inflammatory cells to the site of injury, promote cell migration and cell division to replace dead cells, and activate the immune system in anticipation of microbial invasion. Many of these events involve high‐mobility group box 1 protein (HMGB1), a nuclear protein that is released passively when necrotic cells lose the integrity of their membranes. HMGB1 behaves as a trigger of inflammation, attracting inflammatory cells, and of tissue repair, recruiting stem cells and promoting their proliferation. Moreover, HMGB1 activates dendritic cells (DCs) and promotes their functional maturation and their response to lymph node chemokines. Activated leukocytes actively secrete HMGB1 in the microenvironment. Thus, HMGB1 acts in an autocrine/paracrine fashion and sustains long‐term repair and defense programs. DCs secrete HMGB1 several hours after contact with the first maturation stimulus; HMGB1 secretion is critical for their ability to reach the lymph nodes, to sustain the proliferation of antigen‐specific T cells, to prevent their activation‐dependent apoptosis, and to promote their polarization towards a T‐helper 1 phenotype. These immune responses will also be directed against self‐antigens that DCs process at the time of injury and can lead to autoimmunity.

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Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401
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Bierhaus, A., Humpert, P. M., Morcos, M., Wendt, T., Chavakis, T., Arnold, B., Stern, D. M., & Nawroth, P. P. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0688-7 · Cited by 1,297
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Research works printed but not linked: 1

Fiuza C, 2002, Inflammatory promoting activity of HMGB1 on human microvascular endothelial cells, Blood, 27, 2652

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Suda, K., Takeuchi, H., Hagiwara, T., Miyasho, T., Yamada, S., Inoue, T., Okamoto, M., Wada, N., Saikawa, Y., Fukunaga, K., et al. (2010) · ASAIO Journal · doi:10.1097/mat.0b013e3181d68fa4 · Cited by 6
[News in severe clinical adverse drug reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)].
Martínez‐Cabriales, S. A., Gómez‐Flores, M., & Ocampo-Candiani, J. G. (2015) · PubMed · Cited by 6
Cardiovascular Risk in Patients With Takayasu Arteritis Directly Correlates With Diastolic Dysfunction and Inflammatory Cell Infiltration in the Vessel Wall: A Clinical, ex vivo and in vitro Analysis
Cicco, S., Desantis, V., Vacca, A., Cazzato, G., Solimando, A. G., Cirulli, A., Noviello, S., Susca, C., Prete, M., Brosolo, G., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.863150 · Cited by 6
Lipopolysaccharides protect mesenchymal stem cell against cardiac ischemia-reperfusion injury by HMGB1/STAT3 signaling
Xu, B., Wen, J., Peng, H.-X., Wang, D., Wen, Z., Liu, Y.-T., Qu, J., Cui, H.-X., Wang, Y.-Y., Du, Y.-L., et al. (2023) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2023.11.007 · Cited by 6
Synergistic effect of high‐mobility group box‐1 and lipopolysaccharide on cytokine induction in bovine peripheral blood mononuclear cells
Appavoo, E., Hajam, I. A., Muneeswaran, N. S., Kondabattula, G., Bhanuprakash, V., & Kishore, S. (2015) · Microbiology and Immunology · doi:10.1111/1348-0421.12350 · Cited by 6
Spleen, as an Optimal Site for Islet Transplantation and a Source of Mesenchymal Stem CellsPreprint
Sakata, N., Yoshimatsu, G., & Kodama, S. (2018) · Preprints.org · doi:10.20944/preprints201802.0101.v2 · Cited by 6
The relationship between ghrelin, epilepsy-related inflammatory biomarkers (IL-1β, IL-1R1, HMGB1), and drug-resistant epilepsy in children
Durgut, B. D., Dilber, B., Kamaşak, T., Yaman, H., Saz, Ö. F., Kolaylı, C. C., Kart, P. Ö., Şahin, S., & Cansu, A. (2025) · Epilepsy Research · doi:10.1016/j.eplepsyres.2025.107553 · Cited by 5
Neuroinflammatory regulatory role of microglia in optic nerve injury: from pathological mechanisms to therapeutic targets
Gao, M., Zhou, J., Shi, N., Yan, X., & Liang, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1742677 · Cited by 5
The interplay between autophagy and immunogenic cell death: nanomaterial-based strategies for cancer immunotherapy
Khorrami, M., Fadaie, M., Dizaji, S. R., Davoodi, A., Asghari, R., Shen, J., Rahimmanesh, I., Sethi, G., & Makvandi, P. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04286-5 · Cited by 5
Use of Machine Learning for the Identification and Validation of Immunogenic Cell Death Biomarkers and Immunophenotypes in Coronary Artery Disease
Zhang, Y.-J., Huang, C., Zu, X., Liu, J., & Li, Y. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s439315 · Cited by 5
Necroptosis in apical periodontitis: A programmed cell death with multiple roles
Liu, H., Fan, W., & Fan, B. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31073 · Cited by 5
HMGB1-TLR Signaling in Rasmussens Encephalitis
Li, T., Gao, Q., & Luan, G. (2016) · Journal of Neuroinfectious Diseases · doi:10.4172/2314-7326.1000223 · Cited by 5
High-mobility Group Box 1 Is Associated with the Inflammatory Infiltration and Alveolar Bone Destruction in Rats Experimental Periapical Lesions
Liu, L., Deng, J., Ji, Q., & Peng, B. (2017) · Journal of Endodontics · doi:10.1016/j.joen.2016.11.014 · Cited by 5
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Chen, W., Wei, J., Wang, L., Zhang, D.-W., Tang, W., Wang, J., Yong, Y., Wang, J., Zhou, Y., Yuan, L., et al. (2019) · Trials · doi:10.1186/s13063-019-3889-z · Cited by 5
Theories of Aging and Chronic Diseases: Chronic Inflammation an Interdependent ‘Roadmap’ to Age-Associated Illnesses
Khatami, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-66475-0_3 · Cited by 6
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Ge, X., Nithyananthan, S., Song, Z., Désert, R., Han, H., Das, S., Komakula, S. S. B., Wang, C., Lantvit, D. D., Ge, Z., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000549 · Cited by 4
Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders
Balosso, S., Vezzani, A., & Ravizza, T. (2021) · Progress in inflammation research · doi:10.1007/978-3-030-67403-8_2 · Cited by 4
Could Serum HMGB1 Levels be a Predictor Associated with Psoriatic Arthritis?
Yıldırım, D., Baykul, M., Edek, Y. C., Gülengül, M., Alp, G. T., Eroğlu, F., Adışen, E., Küçük, H., Erden, A., Göker, B., et al. (2023) · Biomarkers in Medicine · doi:10.2217/bmm-2023-0490 · Cited by 4
Tezepelumab: patient selection and place in therapy in severe asthma
Menzella, F., Munari, S., Corsi, L., Tonin, S., Cestaro, W., Ballarin, A., Floriani, A., Dartora, C., & Senna, G. (2024) · Journal of International Medical Research · doi:10.1177/03000605241246740 · Cited by 5
FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+ T Cells
Chauhan, A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601954 · Cited by 4
Inflammation
Hubbard, J. A., & Binder, D. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802401-0.00013-2 · Cited by 4
A Soluble Receptor for Advanced Glycation End Product Levels in Patients with Systemic Lupus Erythematosus
Bayoumy, N. M. K., EL-SHABRAWI, M., & NADA3, H. (2013) · Archives of Rheumatology · doi:10.5606/tjr.2013.2845 · Cited by 4
Expression profiles of HMGB1 on B-CLL related leukocytes contribute to prediction of relapse
Schmohl, J. U., Guenther, T., Sutanto, W., Schuster, F. R., Kroell, T., Hartmann, A., Salih, H. R., Stoetzer, O. J., & Schmetzer, H. M. (2020) · Immunobiology · doi:10.1016/j.imbio.2020.152048 · Cited by 4
Amniotic Stem Cell-Conditioned Media for the Treatment of Nerve and Muscle Pathology: A Systematic Review
Gwam, C. U., Emara, A. K., Mohamed, N. S., Chughtai, N., Plate, J. F., & Ma, X. (2021) · Surgical Technology Online · doi:10.52198/21.sti.38.hr1387 · Cited by 4
Sox2 as a servant of two masters
Mankan, A. K., & Hornung, V. (2015) · Nature Immunology · doi:10.1038/ni.3121 · Cited by 4
Protein glycoxidation in neuropsychiatric disorders—from basic research to clinical practice
Orlof, W., & Maciejczyk, M. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104190 · Cited by 3
Damage-associated Molecular Patterns in Clinical and Animal Models of Uveitis
Kaplan, H. J., Sun, D., & Shao, H. (2021) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2021.1954203 · Cited by 3
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Abou‐Raya, A., Kamel, M. A. E.-N., Sayed, E. A. G., & El-Sharkawy, A. A. H. (2015) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2015.06.005 · Cited by 3
Successful treatments with polymyxin B hemoperfusion and recombinant human thrombomodulin for fulminant Clostridium difficile-associated colitis with septic shock and disseminated intravascular coagulation: a case report
Minami, K., Sakaguchi, Y., Yoshida, D., Yamamoto, M., Ikebe, M., Morita, M., & Toh, Y. (2016) · Surgical Case Reports · doi:10.1186/s40792-016-0199-5 · Cited by 3
Coffee and Bone Metabolism
Sakai, E., & Tsukuba, T. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00096-6 · Cited by 3

Authors: Bianchi, M. E., & Manfredi, A. A.
Affiliations: Vita-Salute San Raffaele University (IT)
Corresponding author: Bianchi, Marco E.
ORCID: Bianchi, Marco E.
Manfredi, Angelo A.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2007-10-30
Volume: 220
Issue: 1
Pages: 35-46
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2007.00574.x
OpenAlex: W2109590683
Cited by: 600
References: 86
Citations by year: 2026: 13 · 2025: 10 · 2024: 13 · 2023: 20 · 2022: 28 · 2021: 21 · 2020: 17 · 2019: 25 · 2018: 41 · 2017: 34 · 2016: 26 · 2015: 37 · 2014: 44 · 2013: 55 · 2012: 45
FWCI: 5.25
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Funders: Associazione Italiana per la Ricerca sul Cancro
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords: HMGB1, high mobility group box 1, innate immunity, adaptive immunity, inflammation, tissue repair, dendritic cell maturation, T cell activation, autoimmunity, necrosis, chemokines, stem cell recruitment, autocrine and paracrine signaling
MeSH terms: Animals, Dendritic Cells, Humans, Immunity, Innate, Lupus Erythematosus, Systemic, T-Lymphocytes, Autoimmunity, Sepsis, HMGB1 Protein, Toll-Like Receptors

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High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity

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