High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

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Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

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DAMPs, PAMPs and alarmins: all we need to know about danger

Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette-Zlatanova, B. C., Shlomchik, M. J., & Marshak‐Rothstein, A. (2002) · Nature · doi:10.1038/416603a · Cited by 1,929

Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,582

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

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Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372

Understanding RAGE, the receptor for advanced glycation end products

Bierhaus, A., Humpert, P. M., Morcos, M., Wendt, T., Chavakis, T., Arnold, B., Stern, D. M., & Nawroth, P. P. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0688-7 · Cited by 1,297

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A., & Bianchi, M. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg516 · Cited by 1,252

HMGB1 as a Key Modulator in Nasal Inflammatory Disorders: A Narrative Review

Passàli, D., Bellussi, L. M., Santantonio, M., & Passàli, G. C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14155392 · Cited by 2

4-Octyl itaconate-induced Nrf2 nuclear translocation mitigates Caspase-11-dependent noncanonical macrophage pyroptosis and acute lung injury

Wen, T., Shi, J., Guo, M., Ma, B., Zhang, C., Zhao, Y., & Xu, F. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.05.011 · Cited by 2

Folic acid-modified antigen-trapping nanoprobes for developing in situ tumor vaccines to inhibit metastasis and recurrence of ovarian cancer

Zhong, X., Pu, T., Cheng, Y., Li, Y. Y., Wang, Q., & Wang, B. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04537-5 · Cited by 2

Receptor for Advanced Glycation End Products is Required for HMGB1/S100A4/NF-κβ Interaction In Porphyromonas gingivalis Induced Gingival Inflammation

He, D., Sun, J., BHAWAL, U. K., Fukuoka, C. Y., Huang, Y.-C., Hamada, N., & Arakawa, H. (2014) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.23.55 · Cited by 2

Heme oxygenase-1 gene delivery for altering high mobility group box-1 protein in pancreatic islet

Kim, M. J., Hwang, Y. H., Hwang, J. W., Alam, Z., & Lee, D. Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.031 · Cited by 2

Goeckerman Regimen Reduces Alarmin Levels and PASI Score in Paediatric Patients with Psoriasis

Holmannová, D., Císařová, B., Borský, P., Fiala, Z., Andrýs, C., Hamáková, K., Švadláková, T., Krejsek, J., Palička, V., Kotingová, L., et al. (2021) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2022.3 · Cited by 2

Polly Matzinger's “danger model” finds its predicted danger-denoting self moieties

Palazón, A., Dubrot, J., Martínez‐Forero, I., Rouzaut, A., Ochoa, C., Perez‐Gracia, J. L., Hervás‐Stubbs, S., & Melero, I. (2008) · Inmunología · doi:10.1016/s0213-9626(08)70068-4 · Cited by 2

HMGB1: un lien entre inflammation septique et non septique

Barnay‐Verdier, S., Maréchal, V., & Borde, C. (2009) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(09)70310-7 · Cited by 2

Measuring serum levels of high-mobility group box 1 by enzyme-linked immunosorbent assay does not identify bacterial infections in patients with systemic lupus erythematosus

Tang, K., Hsieh, T., Chen, Y., Hsieh, C.-W., Chen, Y., & Chen, D.-Y. (2014) · Lupus · doi:10.1177/0961203314530791 · Cited by 2

Roles for Infections in Systemic Lupus Erythematosus Pathogenesis

Vista, E. S., Farris, A. D., & James, J. A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374994-9.10024-5 · Cited by 2

Translational Nephrology: Taking Aim at Tubular Debris

Lindquist, J. A., & Mertens, P. R. (2016) · Journal of Clinical & Experimental Nephrology · doi:10.21767/2472-5056.100012 · Cited by 2

Endogenous DAMPs, Category I: Constitutively Expressed, Native Molecules (Cat. I DAMPs)

Land, W. (2018) · Damage-Associated Molecular Patterns in Human Diseases · doi:10.1007/978-3-319-78655-1_12 · Cited by 2

A Cicada Antimicrobial Peptide, Cryptonin, Exhibits Potent Antitumor Activity by Necrosis on Human Melanoma Cells

Sancar, S., Torkay, G., & Çan, T. (2023) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-023-10540-3 · Cited by 2

Oxidative Stress-Induced Molecular and Genetic Mechanisms in Human Health and Diseases

Dholia, N., Ramteke, P., Varghese, J. F., Rani, V., & Yadav, U. C. S. (2014) · Springer eBooks · doi:10.1007/978-81-322-2035-0_7 · Cited by 2

Phagocytes and Immunoglobulins

Martínez‐Pomares, L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394802-1.00005-4 · Cited by 2

An indel polymorphism in the 3’ untranslated region of HMGB1 confers risk for hepatocellular carcinoma by regulating HMGB1 transcriptional activity in a Chinese population

Wang, J., Zhu, J., Mao, D. H., Zhu, S., Mi, X. G., & Yu, Q. (2019) · Neoplasma · doi:10.4149/neo_2019_190221n147 · Cited by 2

Pleiotropic and Differential Functions of IL-1α and IL-1β Shape the Tumor Microenvironment and Affect the Outcome of Malignancies

Apte, R. N., & Voronov, E. (2013) · Springer eBooks · doi:10.1007/978-94-007-6217-6_8 · Cited by 1

Neuroinflammation in the Genesis of Epilepsy

Rani, R., Paliwal, S., & Nain, S. (2025) · Current Psychopharmacologye · doi:10.2174/0122115560347296250211081124 · Cited by 1

Interplay of trauma-triggered auto-inflammation and T-cell auto-reactivity in posttraumatic dystrophy

Scola, E. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1404161 · Cited by 1

Genetic influence underlying individual variation in vaccine responses in a White Leghorn laying hen line

Racanati, A., Tribout, T., Sabuj, A. A. M., Blanc, F., Cuyabano, B. C. D., Lecoeur, A., Brard‐Fudulea, S., Bruneau, N., Gourichon, D., Bécot, L., et al. (2025) · animal · doi:10.1016/j.animal.2025.101686 · Cited by 1

The Role of Short-Chain Fatty Acids Produced by Oral Bacteria in Modulating Oral Immunity

Tsuda, H., & Mikami, Y. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-03176-1_4 · Cited by 1

Proton beam therapy induces protective immunity via HMGB1-dependent signaling

Wen, J., Tu, X., Ren, W., Wang, Q., Wang, Y., Guo, G., Osada, K., Shimokawa, T., Akihisa, T., Nakajima, N. I., et al. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1686678 · Cited by 1

TLR2 Activation Enhances Inflammatory Signaling and Accelerates Cyst Growth and Renal Fibrosis in Polycystic Kidney Disease Mice

Wei, A., Zhang, Y., 许禹, Schneider, J., Detterman, N., Shu, X., Gregersen, T., Folch, M. N., Li, Y., Chen, S., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093853 · Cited by 1

Caffeic Acid and Its Derivatives as Potential Therapies for Neurological Disorders

Nasrullah, M. Z. (2026) · Current Neuropharmacology · doi:10.2174/011570159x433688260331181025 · Cited by 1

Host Pattern Recognition Receptors (Toll-Like Receptors, RIG-I-Like Receptors, NOD-Like Receptors) and Atherosclerosis

Feldmann, M., & Monaco, C. G. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0338-8_18 · Cited by 1

The role of HMGB1 protein in chronic rhinosinusitis with nasal polyposis - is it a real proinflammatory mediator?

Iosif, C., Jianu, M. E., Sarafoleanu, C., Duda, R., Panaitescu, E., & Davila, C. (2013) · Cited by 1

Cross-talk between bone marrow mesenchymal stem cells and injured tissue

Tamai, K. (2016) · Annals of Japan Prosthodontic Society · doi:10.2186/ajps.8.342 · Cited by 1

Release of High Mobility Protein Box-1 is Greatly Regulated by Nuclear Factor of Activated T Cell-2 in Human Monocytes

Liu, H., Zhao, Q., Song, Q., Zhou, F.-H., Kang, H.-J., Pan, L., & Ym, Y. (2014) · European Journal of Inflammation · doi:10.1177/1721727x1401200110 · Cited by 1

Myeloid-derived Suppressor Cells in Cancer: A Review on the Pathogenesis and Therapeutic Potentials

Richard, S. A. (2018) · The Open Cancer Immunology Journal · doi:10.2174/1876401001807010016 · Cited by 1

Linking Interaction between Antimicrobial Peptide and High Motility Group Box-1 (HMBG-1) in Bacterial Infection

Febriza, A., & Idrus, H. H. (2024) · The Open Biochemistry Journal · doi:10.2174/011874091x277312231123093133 · Cited by 1

A Single Interfacial Point Mutation Rescues Solution Structure Determination of the Complex of HMG‐D with a DNA Bulge

Hill, G. R., Yang, J., Easton, L. E., Cerdan, R., McLaughlin, S. H., Stott, K. M., TRAVERS, A. A., & Neuhaus, D. (2024) · ChemBioChem · doi:10.1002/cbic.202400395 · Cited by 1

Gene Therapy for Cognitive Recovering After Ischemic Stroke

Vargas, J. A. G., Posada‐Duque, R., & Cardona‐Gómez, G. P. (2017) · Springer series in translational stroke research · doi:10.1007/978-3-319-66679-2_13 · Cited by 1

Cell Death and Autoimmune Disease

Gallucci, S., Caricchio, R., & Cohen, P. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00016-6 · Cited by 1

Beyond Acute Traumatic Brain Injury: Molecular Implications of Associated Neuroinflammation in Higher-Order Cognitive Processes

Montivero, A., Ghersi, M., Catalan, J., Formica, M. L., Camacho, N., Culasso, A. F., Hereñú, C. B., Palma, S. D., & Pérez, M. F. (2021) · Springer eBooks · doi:10.1007/978-3-030-61721-9_20 · Cited by 1

Recent Advances in Scar Biology

Ogawa, R. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-399-7 · Cited by 1

Study of the Transcutaneous Auricular Vagus Nerve Stimulation May Advance Outcome in Chronic Pediatric Inflammatory Diseases

Andersson, U. (2022) · Medical Research Archives · doi:10.18103/mra.v10i5.2783 · Cited by 1

Neuroprotection by erythropoietin

Cervellini, I. (2012) · University of Brighton Repository (University of Brighton) · Cited by 1

[Diagnosis of dementia--an objective examination or a subjective evaluation?].

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Anticancer activity of bovine lactoferricin and a cytolytic 9-mer peptide : from milk to cancer vaccine?

Berge, G. M. (2009) · NORA - Norwegian Open Research Archives · Cited by 1

High Mobility Group Protein 1 (HMGB1) And Its Role As A Global Transcription Regulator In Response To Temperature Fluctuations In The Annual Killifish Austrofundulus limnaeus

Alla, V. (2000) · doi:10.15760/etd.239

Role of HMGB1 in Periodontal Disease

Ebe, N., Hara‐Yokoyama, M., & Izumi, Y. (2013) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4614-9557-4_11

The role of the cytokines IL-17A and IL-33 in inflammatory arthritis and psoriasis

Hueber, A. J. (2011) · Enlighten: Theses (The University of Glasgow) · doi:10.5525/gla.thesis.2629

Fisiopatologia della disfunzione epatica nel diabete di tipo 2: nuovi biomarker di rischio e/o patologia

Coppola, A. (2009) · Cineca Institutional Research Information System (Tor Vergata University) · doi:10.58015/coppola-andrea_phd2009-11-03

Reversing Breast Cancer-Induced Immune Suppression

Beury, D. W., & Ostrand‐Rosenberg, S. (2013) · doi:10.21236/ada573503

Effect of glycated proteins and inhibitory compounds intervening with the AGE-RAGE pathway on macrophages

Younessi, P. (2010)

SYNTHESIS AND CHARACTERIZATION OF POLYMERIC ANTIOXIDANT DELIVERY SYSTEMS

Wattamwar, P. P. (2011) · UKnowledge (University of Kentucky)

The impact of the serum levels of soluble receptor for advanced glycation end products (sRAGE) and its ligand S100A12 for the course and extent of lung involvement in smear positive pulmonary tuberculosis in a cohort study in Hyderabad - India.

Berrocal Almanza, L. C. (2015) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-11018

Dendritic cell responses to apoptotic cells : Is there life after death?

Johansson, U. (2010) · Figshare

Cellular Injury and Apoptosis

Gallucci, S., Caricchio, R., & Cohen, P. L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-384929-8.00017-4

Tolerization to Brain and Vascular Antigens: Targeting Autoimmunity After Acute Brain Injuries and Preventing Stroke

Becker, K. J., & Hallenbeck, J. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8915-3_16

Coordinated Regulation of MAPK and STAT3 Proteins on TNF-α Transcription Activity*

Li-Ping, Y. A. N. G., Yao, Y.-M., Li, J., Ye, Q., & Sheng, Z. (2009) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2008.00552

The Quantum of Initial Transformed Cells Potentially Modulates the Type of Local Inflammation Mechanism Elicited by Surrounding Normal Epithelial Tissues and Systemic Immune Pattern for Tumor Arrest or Progression

Owusu, L., Wang, B., Du, Y., Li, W., & Xin, Y. (2015) · Journal of Cancer · doi:10.7150/jca.10787

Research Highlight Ancient News: HMGBs are Universal Sentinels

Bianchi, M. E., & Celona, B. (2015)

Maternal immune characteristics and innate immune responses in the child in relation to allergic disease

Amoudruz, P. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

HMGB1 in inflammation - secretion and function

Wähämaa, H. (2008) · Figshare

The Role Of Inflammation In A New Rabbit Model Of Post-Traumatic Osteoarthritis

Huebner, K. D. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28326

The influence of gut-derived bacteria on systemic adaptive immune responses

Bonn, R. F.-W.-U., & Schwandt, T. (2010) · bonndoc (University of Bonn)

Activation of Innate Immunity Regression through an HMGB1-Mediated DNA Alkylating Therapy Induces Tumor

Crawford, C. L., Zong, W., Sabino, G. J., Furie, M. B., Kew, R. R., Guerriero, L., Ditsworth, D., & Catanzaro, J. M. (2011)

Thrombomodulin-Protein-C-System und Protein Z

Vinnikov, I. A., Nawroth, P. P., & Isermann, B. (2010) · Springer eBooks · doi:10.1007/978-3-642-01544-1_26

Mechanisms mediating macrophage activation during acetaminophen-induced hepatotoxicity

Dragomir, A.-C. (2012) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3xw4hm7

Inflammation and epilepsy: the contribution of astrocytes

Zurolo, E. (2013) · UvA-DARE (University of Amsterdam)

Regulation of Innate Immune Responses by Nucleic Acid Analogues

Yanai, H. (2011) · Uirusu · doi:10.2222/jsv.61.141

Experimental and clinical findings of HMGB1 in sepsis and inflammation

Okamoto, K., Nagato, M., Tamura, T., Higure, A., & Yamaguchi, K. (2010) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.21.619

Drosophila immune responses in a model for epithelial hypertrophy

Krautz, R. (2016)

Modulatory actions of HMGB1 on TLR4 and rage in the primary afferent sensory neuron

Allette, Y. M. (2015) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2099

HMGB-1 Release and the CD8+ T Cell Response Elicited by Radiation Treatment in Malignant Pleural Mesothelioma

Wu, M. O. (2015) · TSpace (University of Toronto)

Platelet activation in trauma and other inflammatory conditions

Montague, S. J. (2017) · University of Birmingham Institutional Research Archive (University of Birmingham)

Helminth-Derived Immunomodulatory

Adisakwattana, M., & Saunders, S. P. (2009)

Terapia génica en enfermedades neurodegenerativas y demencia post infarto cerebral: perspectiva de traslación

Vargas, J. A. G., & Cardona‐Gómez, G. P. (2017) · Revista de la Academia Colombiana de Ciencias Exactas Físicas y Naturales · doi:10.18257/raccefyn.437

Molecular Mechanisms of Immunogenic Cell Death

Musella, M., Manic, G., Vitale, I., & Sistigu, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.12294-0

HMGB1 INDUCES TENDINOPATHY DEVELOPMENT DUE TO MECHANICAL OVERLOADING

Zhang, J., Zhao, G., Li, F., & Hc, J. (2017) · D-Scholarship@Pitt (University of Pittsburgh)

Development of New Antibody Based Theranostic Agents Targeting the Receptor for Advanced Glycation End-Product (Rage)

Jyoti, F. (2013) · NDSU Repository (North Dakota State University)

Co-localization of the Receptor for Advanced Glycation End Products (RAGE) with S100 Calcium-Binding Protein B (S100B) in Human Umbilical Vein Endothelial

Serratos, I. N., López-Macay, Á., Castellanos, P., Córdoba-Herrera, J. G., Pérez‐Montfort, R., Cabrera, N., Arechavaleta-Velasco, F., Domínguez-López, P., & Santamarı́a, A. (2019) · Journal of the Mexican Chemical Society · doi:10.29356/jmcs.v63i1.574

Étude des mécanismes d'action de la PhotoChimiothérapie Extra-corporelle chez l'Homme

Hannani, D. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)

Development and clinical application of regeneration-inducing HMGB1 peptide drug

Tamai, K. (2021) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.32.289

Faculty Opinions recommendation of HMGB1 and cord blood: its role as immuno-adjuvant factor in innate immunity.

Manfredi, A. A., Campana, L., & Cottone, L. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13370988.14741094

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Optimisation de peptides agonistes du récepteur CD47 : induction d'un nouveau type de mort cellulaire programmée contre les formes réfractaires de leucémie lymphoïde chronique

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Alteration of Reproductive Function via Activation of HMGB1/RAGE/TLR4 Signaling Pathway in the Testis of Dysbiosis-induced MicePreprint

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