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Cited by 218Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited

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Boniface, Katia, Blom, Bianca, Liu, Yong‐Jun, De Waal Malefyt, René·2008·Immunological Reviews
DOI 10.1111/j.1600-065x.2008.00714.xPMC PMC3660846
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Abstract

Summary: Protracted inflammation leading to dysregulation of effector T‐cell responses represents a common feature of a wide range of autoimmune diseases. The interleukin‐12 (IL‐12)/T‐helper 1 (Th1) pathway was thought to be responsible for the pathogenesis of multiple chronic inflammatory diseases, including psoriasis, inflammatory bowel disease, arthritis, or multiple sclerosis, mainly through their production of interferon‐γ and its effects on macrophage activation and chemokine production. However, this initial concept of T‐cell‐mediated chronic inflammation required an adjustment with the discovery of an IL‐12‐related cytokine, designated IL‐23. IL‐23 was rapidly recognized for its involvement in the establishment of chronic inflammation and in the development of a Th cell subset producing IL‐17, designated Th17, which is distinct from the previously reported Th1 and Th2 populations. This review aims to describe the characterization of IL‐23 and its receptor, its biological activities, as well as its involvement in the development of human Th17 cells and autoimmunity.

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  • Excessive cytokines IL-4, IL-5, and IL-13 produced by Th2 cells are significant risk factors in asthma pathogenesis.

    “Therefore, excessive cytokines IL-4, IL-5, and IL-13 produced by Th2 cells are significant risk factors in asthma pathogenesis [19].”

    From Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma (2016) · cites this paper as [19]

    The section on IL-23/Th17 and IL-12/Th1-mediated autoimmune diseases reports that Th2 cells were identified in inflamed tissue from patients with severe asthma. It does not say that excessive Th2-derived IL-4, IL-5, and IL-13 are significant risk factors in asthma pathogenesis. The Characterization of IL-23 bioactivity section mentions IL-4 and IL-13 in relation to IgE production, not asthma risk. (LLM, conf=0.84)

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Authors
Boniface, K., Blom, B., Liu, Y., & De Waal Malefyt, R.
Affiliations
  • University of Amsterdam (NL)
  • The University of Texas MD Anderson Cancer Center (US)
ORCID
Venue
Immunological Reviews
Publisher
Wiley
Published
2008-10-30
Volume
226
Issue
1
Pages
132-146
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
DOI
10.1111/j.1600-065x.2008.00714.x
PMC
PMC3660846
OpenAlex
W2011324075
Cited by
218
References
13
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FWCI
1.91
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01AI062888)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
IL-23, IL-12, Th17 cells, T helper cell differentiation, Th1 cells, Th2 cells, autoimmunity, chronic inflammation, IL23R, IL-17, interferon-gamma, psoriasis, inflammatory bowel disease, multiple sclerosis, arthritis
MeSH terms
Autoimmune Diseases, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Humans, Inflammation, Transcription Factors, Signal Transduction, Cytokines, Transforming Growth Factor beta, Interleukin-12, Interleukin-17, Interleukin-1beta, Interleukin-23

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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