Regulation of inflammatory responses by IL-17F
Open accessAbstract
Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which has an expression pattern regulated similarly to IL-17, is poorly understood. We show that like IL-17, IL-17F regulates proinflammatory gene expression in vitro, and this requires IL-17 receptor A, tumor necrosis factor receptor–associated factor 6, and Act1. In vivo, overexpression of IL-17F in lung epithelium led to infiltration of lymphocytes and macrophages and mucus hyperplasia, similar to observations made in IL-17 transgenic mice. To further understand the function of IL-17F, we generated and analyzed mice deficient in IL-17F or IL-17. IL-17, but not IL-17F, was required for the initiation of experimental autoimmune encephalomyelitis. Mice deficient in IL-17F, but not IL-17, had defective airway neutrophilia in response to allergen challenge. Moreover, in an asthma model, although IL-17 deficiency reduced T helper type 2 responses, IL-17F–deficient mice displayed enhanced type 2 cytokine production and eosinophil function. In addition, IL-17F deficiency resulted in reduced colitis caused by dextran sulfate sodium, whereas IL-17 knockout mice developed more severe disease. Our results thus demonstrate that IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases.
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Fate-mapping studies show IL-23R-dependent differentiation of IL-17-producing cells into encephalitogenic IFNγ-producing Th1/Th17 cells.
“Fate-mapping studies using IL-17-fate reporter mice showed IL-23R-dependent differentiation of IL-17-producing cells into encephalitogenic IFNγ-producing Th1/Th17 cells”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [76]
Cell fate reporter mice showed that T cells initially expressing IL-17 (ex-Th17 cells) can subsequently express proinflammatory cytokines including IFNγ and GM-CSF.
“Use of cell fate reporter mice showed that T cells that initially express IL-17 (ex-Th17 cells) can subsequently express proinflammatory cytokines, including IFNγ and GM-CSF [38, 76].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [76]
Under inflammatory conditions, tissue Th17 cells exhibit plastic changes in their effector programs.
“Under inflammatory conditions, tissue Th17 cells have been reported to exhibit plastic changes in their effector programs.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [76]
In the absence of IL-23, Th17 cells lose the ability to up-regulate IFNγ and GM-CSF.
“In the absence of IL-23, Th17 cells lose the ability to up-regulate IFNγ and GM-CSF [76].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [76]
IL-23 is a key driver of the Th17 cell transition towards a pathogenic phenotype.
“A key driver of the Th17 cell transition towards a pathogenic phenotype is the cytokine IL-23.”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [76]
GM-CSF+ T cells co-express a great variety of other cytokines including IL-2, IL-3, IL-4, IL-6, IL-13, IL-17A, IL-22, IFNγ, and TNF.
“This conclusion is further supported by the findings that GM-CSF+ T cells co-express a great variety of other cytokines including IL-2, IL-3, IL-4, IL-6, IL-13, IL-17A, IL-22, IFNγ, and TNF [33, 36, 76, 175].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [76]
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Cites
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265 · see citing works
Self-citationIL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371 · see citing works
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., & Ouyang, W. (2007) · Nature · doi:10.1038/nature05505 · Cited by 2,034 · see citing works
Zhu, Z., Homer, R., Wang, Z., Chen, Q., Geba, G. P., Wang, J., Zhang, Y., & Elias, J. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5909 · Cited by 1,704 · see citing works
Self-citationT Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605 · see citing works
Self-citationYe, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522 · see citing works
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600321200 · Cited by 1,494 · see citing works
Self-citationEssential autocrine regulation by IL-21 in the generation of inflammatory T cells
Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works
Self-citationTh17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422 · see citing works
Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice
Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6173 · Cited by 1,272 · see citing works
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053 · see citing works
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A.-M., Painter, S. L., Comeau, M. R., Cohen, J. I., & Spriggs, M. K. (1995) · Immunity · doi:10.1016/1074-7613(95)90070-5 · Cited by 995 · see citing works
Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17
Stark, M. A., Huo, Y., Burcin, T. L., MORRIS, M. A., Olson, T. S., & Ley, K. F. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.011 · Cited by 945 · see citing works
ICOS co-stimulatory receptor is essential for T-cell activation and function
Dong, C., Juedes, A. E., Temann, U.-A., Shresta, S., Allison, J. P., Ruddle, N. H., & Flavell, R. A. (2001) · Nature · doi:10.1038/35051100 · Cited by 936 · see citing works
Self-citationInterleukin-17 family and IL-17 receptors
Moseley, T. A., Haudenschild, D. R., Rose, L., & Reddi, A. H. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00002-9 · Cited by 917 · see citing works
Lockhart, E., Green, A. M., & Flynn, J. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4662 · Cited by 767 · see citing works
Hurst, S. D., Muchamuel, T., Gorman, D. M., Gilbert, J. M., Clifford, T., Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T. T., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.443 · Cited by 619 · see citing works
Melgar, S., Karlsson, A., & Michaëlsson, E. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00467.2004 · Cited by 579 · see citing works
Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex
Toy, D., Kugler, D., Wolfson, M., Bos, T. V., Gurgel, J., Derry, J., Tocker, J., & Peschon, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.36 · Cited by 570 · see citing works
Interleukin-17 is a negative regulator of established allergic asthma
Schnyder‐Candrian, S., Togbe, D., Couillin, I., Mercier, I., Brombacher, F., Quesniaux, V. F. J., Fossiez, F., Ryffel, B., & Schnyder, B. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061401 · Cited by 564 · see citing works
Hymowitz, S. G., Filvaroff, E. H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R. F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5332 · Cited by 548 · see citing works
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
Ogawa, A., Andoh, A., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Clinical Immunology · doi:10.1016/j.clim.2003.09.013 · Cited by 495 · see citing works
Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
Dong, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1807 · Cited by 487 · see citing works
Self-citationMcAllister, F. M., Henry, A. C., Kreindler, J. L., Dubin, P. J., Ulrich, L., Steele, C. H., Finder, J. D., Pilewski, J. M., Carreno, B. M., Goldman, S. J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.404 · Cited by 398 · see citing works
Ruddy, M. J., Wong, G. C., Liu, X. K., Yamamoto, H., Kasayama, S., Kirkwood, K. L., & Gaffen, S. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308809200 · Cited by 364 · see citing works
Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
Chang, S. H., Park, H., & Dong, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600256200 · Cited by 356 · see citing works
Self-citationIdentification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F
Kuestner, R. E., Taft, D. W., Haran, A. C., Brandt, C. S., Brender, T., Lum, K. D., Harder, B., Okada, S. L., Ostrander, C. D., Kreindler, J. L., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5462 · Cited by 349 · see citing works
Schwandner, R., Yamaguchi, K., & Cao, Z. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1233 · Cited by 349 · see citing works
Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
Wright, J. F., Guo, Y., Quazi, A., Luxenberg, D. P., Bennett, F., Ross, J. F., Qiu, Y., Whitters, M. J., Tomkinson, K. N., Dunussi-Joannopoulos, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700499200 · Cited by 319 · see citing works
Akimzhanov, A. M., Yang, X. O., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600322200 · Cited by 302 · see citing works
Self-citationCharacterization of Mouse and Human B7-H3 Genes
Sun, M., Richards, S., Prasad, D. V. R., Mai, X. M., Rudensky, A. Y., & Dong, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6294 · Cited by 295 · see citing works
Self-citationA novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
Chang, S. H., & Dong, C. (2007) · Cell Research · doi:10.1038/cr.2007.35 · Cited by 280 · see citing works
Self-citationKawaguchi, M., Takahashi, D., Hizawa, N., Suzuki, S., Matsukura, S., Kokubu, F., Maeda, Y., Fukui, Y., Konno, S., Huang, S.-K., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.1346 · Cited by 257 · see citing works
Bush, K., Farmer, K. M., Walker, J. S., & Kirkham, B. W. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10173 · Cited by 251 · see citing works
Thymic stromal lymphopoietin in normal and pathogenic T cell development and function
Ziegler, S. F., & Liu, Y.-J. (2006) · Nature Immunology · doi:10.1038/ni1360 · Cited by 234 · see citing works
Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
Chung, Y., Yang, X. O., Chang, S. H., Ma, L., Tian, Q., & Dong, C. (2006) · Cell Research · doi:10.1038/sj.cr.7310106 · Cited by 232 · see citing works
Self-citationHelper T cells regulate type-2 innate immunity in vivo
Shinkai, K., Mohrs, M., & Locksley, R. M. (2002) · Nature · doi:10.1038/nature01202 · Cited by 201 · see citing works
Identification of a Novel Cytokine, ML-1, and Its Expression in Subjects with Asthma
Kawaguchi, M., Onuchic², L. F., Li, X., Essayan, D. M., Schroeder, J. T., Xiao, H.-Q., Liu, M. C., Krishnaswamy, G. A., Germino, G. G., & Huang, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4430 · Cited by 189 · see citing works
Transcriptional Regulation of Th2 Differentiation by Inducible Costimulator
Nurieva, R., Duong, J., Kishikawa, H., Dianzani, U., Rojo, J. M., Ho, I., Flavell, R. A., & Dong, C. (2003) · Immunity · doi:10.1016/s1074-7613(03)00144-4 · Cited by 148 · see citing works
Self-citationInterleukin-17F Induces Pulmonary Neutrophilia and Amplifies Antigen-induced Allergic Response
Oda, N., Canelos, P., Essayan, D. M., Plunkett, B. A., Myers, A. C., & Huang, S.-K. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-778oc · Cited by 145 · see citing works
Role of interleukin‐17F in chronic inflammatory and allergic lung disease
Hizawa, N., Kawaguchi, M., Huang, S., & Nishimura, M. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02550.x · Cited by 118 · see citing works
Involvement of TNF Receptor-Associated Factor 6 in IL-25 Receptor Signaling
Maezawa, Y., Nakajima, H., Suzuki, K., Tamachi, T., Ikeda, K., Inoue, J., Saito, Y., & Iwamoto, I. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1013 · Cited by 102 · see citing works
A new mechanism regulating the initiation of allergic airway inflammation
Kiss, A., Montes, M., Susarla, S. C., Gyllenbäck, E. J., Drouin, S. M., Wetsel, R. A., Yao, Z., Martin, R., Hamzeh, N. Y., Adelagun, R., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.025 · Cited by 69 · see citing works
Laky, K., Lefrançois, L., & Puddington, L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.3.1417 · Cited by 67 · see citing works
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Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works
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Neurath, M. F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3661 · Cited by 2,706 · see citing works
Intestinal homeostasis and its breakdown in inflammatory bowel disease
Maloy, K. J., & Powrie, F. M. (2011) · Nature · doi:10.1038/nature10208 · Cited by 1,876 · see citing works
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806 · see citing works
Structure and signalling in the IL-17 receptor family
Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475 · see citing works
Targeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414 · see citing works
Functional Specialization of Interleukin-17 Family Members
Iwakura, Y., Ishigame, H., Saijo, S., & Nakae, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.012 · Cited by 1,289 · see citing works
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Raphael, I., Nalawade, S. A., Eagar, T. N., & Forsthuber, T. G. (2014) · Cytokine · doi:10.1016/j.cyto.2014.09.011 · Cited by 1,177 · see citing works
Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs
Yang, X. O., Nurieva, R., Martínez, G., Kang, H. S., Chung, Y., Pappu, B. P., Shah, B., Chang, S. H., Schluns, K. S., Watowich, S. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.007 · Cited by 1,129 · see citing works
Self-citationNurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.009 · Cited by 1,205 · see citing works
Self-citationProinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases
Strober, W., & Fuss, I. J. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.016 · Cited by 1,105 · see citing works
El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B. N., & Rostami, A. (2011) · Nature Immunology · doi:10.1038/ni.2031 · Cited by 1,071 · see citing works
“, whereas TNF, IL-21, IL-22 and IL-17F are not required for the development of EA”
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Guan, Q. (2019) · Journal of Immunology Research · doi:10.1155/2019/7247238 · Cited by 1,072 · see citing works
Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.009 · Cited by 1,004 · see citing works
IL-17 and IL-17-producing cells in protection versus pathology
Mills, K. H. G. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00746-9 · Cited by 1,023 · see citing works
Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
Anderson, G. P. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61452-x · Cited by 997 · see citing works
Innate and adaptive immune responses in asthma
Holgate, S. T. (2012) · Nature Medicine · doi:10.1038/nm.2731 · Cited by 907 · see citing works
The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis
Blauvelt, A., & Chiricozzi, A. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8702-3 · Cited by 794 · see citing works
Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases
Akdiş, M., Bürgler, S., Crameri, R., Eiwegger, T., Fujita, H., Alcaide, E. G., Klunker, S., Meyer, N., O’Mahony, L., Palomares, Ó., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.050 · Cited by 780 · see citing works
A protective function for interleukin 17A in T cell–mediated intestinal inflammation
O'Connor Jr, W., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., & Flavell, R. A. (2009) · Nature Immunology · doi:10.1038/ni.1736 · Cited by 756 · see citing works
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease
Friedrich, M., Pohin, M., & Powrie, F. M. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.017 · Cited by 750 · see citing works
Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent
Wilson, M. S., Madala, S. K., Ramalingam, T. R., Gochuico, B. R., Rosas, I. O., Cheever, A. W., & Wynn, T. A. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20092121 · Cited by 730 · see citing works
Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 675 · see citing works
IL-17 family: Cytokines, receptors and signaling
Gu, C., Wu, L., & Li, X. (2013) · Cytokine · doi:10.1016/j.cyto.2013.07.022 · Cited by 597 · see citing works
T-Cell Signaling Regulated by the Tec Family Kinase, ItkPreprint
Andreotti, A. H., Schwartzberg, P. L., Joseph, R. E., & Berg, L. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002287 · Cited by 595 · see citing works
Immunological pathogenesis of inflammatory bowel disease
Lee, S., Kwon, J. E., & Cho, M. (2018) · Intestinal Research · doi:10.5217/ir.2018.16.1.26 · Cited by 581 · see citing works
Inflammation and colorectal cancer: colitis-associated neoplasia
Grivennikov, S. I. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0352-6 · Cited by 555 · see citing works
The Role of IL-17 and related cytokines in inflammatory autoimmune diseases
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IL-17 cytokines in immunity and inflammation
Jin, W., & Dong, C. (2013) · Emerging Microbes & Infections · doi:10.1038/emi.2013.58 · Cited by 528 · see citing works
Self-citationThe roles of IL‐17A in inflammatory immune responses and host defense against pathogens
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Ramirez-Carrozzi, V., Sambandam, A., Luis, E., Lin, Z., Jeet, S., Lesch, J., Hackney, J., Kim, J., Zhou, M., Lai, J., et al. (2011) · Nature Immunology · doi:10.1038/ni.2156 · Cited by 477 · see citing works
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Gruosso, T., Gigoux, M., Manem, V. S., Bertos, N., Zuo, D., Perlitch, I., Saleh, S. M. I., Zhao, H., Souleimanova, M., Johnson, R. M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci96313 · Cited by 445 · see citing works
IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in Mice
Wakashin, H., Hirose, K., Maezawa, Y., Kagami, S., Suto, A., Watanabe, N., Saito, Y., Hatano, M., Tokuhisa, T., Iwakura, Y., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-086oc · Cited by 437 · see citing works
Haworth, O., Cernadas, M., Yang, R., Serhan, C. N., & Levy, B. D. (2008) · Nature Immunology · doi:10.1038/ni.1627 · Cited by 425 · see citing works
Cytokines and Chemokines inMycobacterium tuberculosisInfection
Domingo-Gonzalez, R., Prince, O. A., Cooper, A. M., & Khader, S. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0018-2016 · Cited by 413 · see citing works
Wilson, R. H., Whitehead, G. S., Nakano, H., Free, M. E., Kolls, J. K., & Cook, D. N. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200904-0573oc · Cited by 403 · see citing works
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
Haak, S., Croxford, A. L., Kreymborg, K., Heppner, F. L., Pouly, S., Becher, B., & Waisman, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35997 · Cited by 398 · see citing works
Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD
Doe, C., Bafadhel, M., Siddiqui, S., Desai, D., Mistry, V., Rugman, P., McCormick, M. J., Woods, J., May, R. D., Sleeman, M. A., et al. (2010) · CHEST Journal · doi:10.1378/chest.09-3058 · Cited by 394 · see citing works
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
Sonnenberg, G. F., Nair, M. G., Kirn, T. J., Zaph, C., Fouser, L. A., & Artis, D. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092054 · Cited by 379 · see citing works
Martín‐Orozco, N., Chung, Y., Chang, S. H., Wang, Y., & Dong, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200838475 · Cited by 359 · see citing works
Self-citationInterleukin-17 and its expanding biological functions
Xu, S., & Cao, X. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.21 · Cited by 358 · see citing works
Kudo, M., Ishigatsubo, Y., & Aoki, I. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00263 · Cited by 347 · see citing works
Lipocalin-2: Structure, function, distribution and role in metabolic disorders
Jaberi, S. A., Cohen, A., D’Souza, C. M., Abdulrazzaq, Y. M., Ojha, S. K., Bastaki, S. M. A., & Adeghate, E. A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112002 · Cited by 349 · see citing works
Alcorn, J. F., Crowe, C. R., & Kolls, J. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135926 · Cited by 348 · see citing works
Wang, K., Kim, M. K., Caro, G. D., Wong, J., Shalapour, S., Wan, J., Zhang, W., Zhong, Z., Sánchez‐López, E., Wu, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.11.009 · Cited by 342 · see citing works
Differential regulation of interleukin 17 and interferon production in inflammatory bowel disease
Rovedatti, L., Kudo, T., Biancheri, P., Sarra, M., Knowles, C. H., Rampton, D. S., Corazza, G. R., Monteleone, G., Sabatino, A. D., & MacDonald, T. T. (2009) · Gut · doi:10.1136/gut.2009.182170 · Cited by 336 · see citing works
Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation
Cader, M. Z., & Kaser, A. (2013) · Gut · doi:10.1136/gutjnl-2012-303955 · Cited by 337 · see citing works
Res, P. C. M., Pişkin, G., de Boer, O. J., van der Loos, C. M., Teeling, P., Bos, J. D., & Teunissen, M. B. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014108 · Cited by 324 · see citing works
Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease
Coskun, M., Salem, M. A., Pedersen, J., & Nielsen, O. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.06.007 · Cited by 327 · see citing works
T helper 17 cells play a critical pathogenic role in lung cancer
Chang, S. H., Mirabolfathinejad, S. G., Katta, H., Cumpian, A. M., Gong, L., Caetano, M. S., Moghaddam, S. J., & Dong, C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319051111 · Cited by 326 · see citing works
Self-citationSong, X., Zhu, S., Shi, P., Liu, Y., Shi, Y., Levin, S. D., & Qian, Y. (2011) · Nature Immunology · doi:10.1038/ni.2155 · Cited by 312 · see citing works
Role of Th17 Cells in the Pathogenesis of Human IBD
Gálvez, J. (2014) · ISRN Inflammation · doi:10.1155/2014/928461 · Cited by 317 · see citing works
Jakubczyk, D., Leszczyńska, K., & Górska, S. (2020) · Nutrients · doi:10.3390/nu12071973 · Cited by 314 · see citing works
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity
Leonardi, I., Gao, I. H., Lin, W.-Y., Allen, M., Li, X. V., Fiers, W. D., De Celie, M. B., Putzel, G. G., Yantiss, R. K., Johncilla, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.017 · Cited by 307 · see citing works
Reynolds, J. M., Pappu, B. P., Peng, J., Martínez, G., Zhang, Y., Chung, Y., Ma, L., Yang, X. O., Nurieva, R., Tian, Q., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.010 · Cited by 295 · see citing works
Self-citationChen, X., Wu, X., Zhou, Q., Howard, O. M. Z., Netea, M. G., & Oppenheim, J. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202659 · Cited by 291 · see citing works
TH17 cell heterogeneity and its role in tissue inflammation
Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works
IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential
Zhu, S., & Qian, Y. (2012) · Clinical Science · doi:10.1042/cs20110496 · Cited by 286 · see citing works
The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases
Pappu, R., Ramirez-Carrozzi, V. R., & Sambandam, A. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03465.x · Cited by 282 · see citing works
Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E
Chang, S. H., Reynolds, J. M., Pappu, B. P., Chen, G., Martínez, G., & Dong, C. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.010 · Cited by 273 · see citing works
Self-citationCytokines, IBD, and Colitis-associated Cancer
Francescone, R., Hou, V., & Grivennikov, S. I. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000236 · Cited by 273 · see citing works
Glatt, S., Baeten, D., BAKER, T. S., Griffiths, M., Ionescu, L., Lawson, A. D. G., Maroof, A., Oliver, R., Popa, S., Strimenopoulou, F., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-212127 · Cited by 270 · see citing works
Microbiome, inflammation and colorectal cancer
Chen, J., Pitmon, E., & Wang, K. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.09.006 · Cited by 267 · see citing works
CD4 T-cell differentiation and inflammatory bowel disease
Zenewicz, L. A., Antov, A., & Flavell, R. A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.002 · Cited by 265 · see citing works
Bcl6 expression specifies the T follicular helper cell program in vivo
Liu, X., Yan, X. S., Zhong, B., Nurieva, R., Wang, A., Wang, X., Martín‐Orozco, N., Wang, Y., Chang, S. H., Esplugues, E., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120219 · Cited by 262 · see citing works
Self-citationIL-17 contributes to CD4-mediated graft-versus-host disease
Kappel, L. W., Goldberg, G. L., King, C. G., Suh, D. Y., Smith, O. M., Ligh, C. A., Holland, A. M., Grubin, J., Mark, N. M., Liu, C., et al. (2008) · Blood · doi:10.1182/blood-2008-08-172155 · Cited by 257 · see citing works
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis
Huber, M., Heink, S., Pagenstecher, A., Reinhard, K., Ritter, J., Visekruna, A., Guralnik, A., Bollig, N., Jeltsch, K. M., Heinemann, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63681 · Cited by 255 · see citing works
McGinley, A. M., Sutton, C. E., Edwards, S. C., Leane, C. M., DeCourcey, J., Teijeiro, A., Hamilton, J. A., Boon, L., Djouder, N., & Mills, K. H. G. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.002 · Cited by 248 · see citing works
Sarra, M., Pallone, F., MacDonald, T. T., & Monteleone, G. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21248 · Cited by 249 · see citing works
Lazarevic, V., & Glimcher, L. H. (2011) · Nature Immunology · doi:10.1038/ni.2059 · Cited by 248 · see citing works
Th17 cytokines and their emerging roles in inflammation and autoimmunity
Fouser, L. A., Wright, J. F., Dunussi‐Joannopoulos, K., & Collins, M. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00712.x · Cited by 243 · see citing works
CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease
Gómez-Bris, R., Saéz, Á., Herrero‐Fernández, B., Rius, C., Sánchez-Martinez, H., & González, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032696 · Cited by 255 · see citing works
Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage
Song, X., Dai, D., He, X., Zhu, S., Yao, Y., Gao, H., Wang, J., Qu, F., Qiu, J., Wang, H., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.024 · Cited by 244 · see citing works
Mukherjee, S., Lindell, D. M., Berlin, A. A., Morris, S. B., Shanley, T. P., Hershenson, M. B., & Lukacs, N. W. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.003 · Cited by 238 · see citing works
Th17 Response and Inflammatory Autoimmune Diseases
Waite, J. C., & Skokos, D. (2011) · International Journal of Inflammation · doi:10.1155/2012/819467 · Cited by 239 · see citing works
IL-17 family member cytokines: Regulation and function in innate immunity
Reynolds, J. M., Angkasekwinai, P., & Dong, C. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.002 · Cited by 237 · see citing works
Self-citationToll-like receptor 4 signaling in T cells promotes autoimmune inflammation
Reynolds, J., Martinez, G., Chung, Y., & Dong, C. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1120585109 · Cited by 237 · see citing works
Self-citationEmerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis
Marshall, E. A., Ng, K. W., Kung, S. H. Y., Conway, E. M., Martínez, V. D., Halvorsen, E. C., Rowbotham, D. A., Vucic, E. A., Plumb, A. W., Becker‐Santos, D. D., et al. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0551-1 · Cited by 230 · see citing works
Signaling of interleukin-17 family cytokines in immunity and inflammation
Chang, S. H., & Dong, C. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.11.022 · Cited by 231 · see citing works
Self-citationCD 4+ T‐cell subsets in intestinal inflammation
Shale, M., Schiering, C., & Powrie, F. M. (2013) · Immunological Reviews · doi:10.1111/imr.12039 · Cited by 222 · see citing works
Cytokine networking of innate immunity cells: a potential target of therapy
Střı́ž, I., Brabcová, E., Kolesár, L., & Sekerková, A. (2014) · Clinical Science · doi:10.1042/cs20130497 · Cited by 224 · see citing works
From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited
Boniface, K., Blom, B., Liu, Y., & De Waal Malefyt, R. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00714.x · Cited by 218 · see citing works
STAT3 in CD4+ T helper cell differentiation and inflammatory diseases
Egwuagu, C. E. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.003 · Cited by 218 · see citing works
Alterations of the Gut Microbiota in Hashimoto's Thyroiditis Patients
Zhao, F., Feng, J., Li, J., Zhao, L., Liu, Y., Chen, H., Jin, Y., Zhu, B., & Wei, Y. (2018) · Thyroid · doi:10.1089/thy.2017.0395 · Cited by 217 · see citing works
Gómez‐Rodríguez, J., Sahu, N., Handon, R., Davidson, T. S., Anderson, S. M., Kirby, M., August, A., & Schwartzberg, P. L. (2009) · Immunity · doi:10.1016/j.immuni.2009.07.009 · Cited by 212 · see citing works
IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis
Gasse, P., Riteau, N., Vacher, R., Michel, M.-L., Fautrel, A., di Padova, F., Fick, L., Charron, S., Lagente, V., Eberl, G., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023185 · Cited by 208 · see citing works
Zhong, B., Liu, X., Wang, X., Chang, S. H., Liu, X., Wang, A., Reynolds, J. M., & Dong, C. (2012) · Nature Immunology · doi:10.1038/ni.2427 · Cited by 206 · see citing works
Role of the IL23/IL17 Pathway in Crohn’s Disease
Schmitt, H., Neurath, M. F., & Atreya, R. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622934 · Cited by 208 · see citing works
Biological role of Toll-like receptor-4 in the brain
Trotta, T., Porro, C., Calvello, R., & Panaro, M. A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.01.014 · Cited by 204 · see citing works
T helper 17 cell heterogeneity and pathogenicity in autoimmune disease
Ghoreschi, K., Laurence, A. D. J., Yang, X., Hirahara, K., & O’Shea, J. J. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.007 · Cited by 205 · see citing works
Self-citationAirway mucus: The good, the bad, the sticky
Evans, C. M., & Koo, J. S. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.11.001 · Cited by 207 · see citing works
The activation and regulation of IL-17 receptor mediated signaling
Song, X., & Qian, Y. (2013) · Cytokine · doi:10.1016/j.cyto.2013.03.014 · Cited by 204 · see citing works
IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism
Eken, A., Singh, A. K., Treuting, P. M., & Oukka, M. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.33 · Cited by 204 · see citing works
Regulation and Function of Proinflammatory TH17 Cells
Martínez, G., Nurieva, R., Yang, X. O., & Dong, C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.021 · Cited by 203 · see citing works
Self-citationImmunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics
Lu, Q., Yang, M.-F., Liang, Y.-J., Xu, J., Xu, H.-M., Nie, Y.-Q., Wang, L.-S., Yao, J., & Li, D.-F. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s353038 · Cited by 211 · see citing works
Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
Qu, N., Xu, M., Mizoguchi, I., Furusawa, J.-I., Kaneko, K. J., Watanabe, K., Mizuguchi, J., Itoh, M., Kawakami, Y., & Yoshimoto, T. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/968549 · Cited by 192 · see citing works
- Authors
- Yang, X. O., Chang, S. H., Park, H., Nurieva, R., Shah, B., Acero, L., Wang, Y.-H., Schluns, K. S., Broaddus, R. R., Zhu, Z., & Dong, C.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- 1Department of Immunology
- University of Washington (US)
- Johns Hopkins University (US)
- ORCID
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-04-14
- Volume
- 205
- Issue
- 5
- Pages
- 1063-1075
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2373839
- OpenAlex
- W2110264653
- Cited by
- 739
- References
- 47
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 18 · 2023: 27 · 2022: 40 · 2021: 31 · 2020: 33 · 2019: 27 · 2018: 38 · 2017: 45 · 2016: 39 · 2015: 54 · 2014: 56 · 2013: 56 · 2012: 54
- FWCI
- 28.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-17F, IL-17, inflammation, IL-17 receptor A, TRAF6, Act1, pro-inflammatory gene expression, lung epithelium, experimental autoimmune encephalomyelitis, airway neutrophilia, allergen challenge, asthma, Th2 immune response, eosinophils, colitis, dextran sulfate
- MeSH terms
- Animals, Cell Line, Fibroblasts, Homeostasis, Inflammation, Lymphocyte Activation, Mice, Transgenic, T-Lymphocytes, Transfection, CD4-Positive T-Lymphocytes, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17, Mice
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