The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication
Open accessAbstract
Summary: The continual interaction of the immune system with a developing tumor is thought to result in the establishment of a dynamic state of equilibrium. This equilibrium depends on the balance between effector and regulatory T‐cell compartments. Whereas regulatory T cells can infiltrate and accumulate within tumors, effector T cells fail to efficiently do so. Furthermore, effector T cells that do infiltrate the tumor become tightly controlled by different regulatory cellular subsets and inhibitory molecules. The outcome of this balance is critical to survival, and whereas in some cases the equilibrium can rapidly result in the elimination of the transformed cells by the immune system, in many other cases the tumor manages to escape immune control. In this review, we discuss relevant work focusing on the establishment of the intratumor balance, the dynamic changes in the populations of effector and regulatory T cells within the tumor, and the role of the tumor vasculature and its activation state in the recruitment of different T‐cell subsets. Finally, we also discuss work associated to the manipulation of the immune response to tumors and its impact on the infiltration, accumulation, and function of tumor‐reactive lymphocytes within the tumor microenvironment.
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Cites
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Self-citation
Cited by
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Gubin, M. M., Zhang, X., Schuster, H., Caron, E., Ward, J. P., Noguchi, T., Ivanova, Y., Hundal, J., Arthur, C. D., Krebber, W.-J., et al. (2014) · Nature · doi:10.1038/nature13988 · Cited by 1,974
“…support for the clinical observations that (a) checkpoint blockade therapy amplifies, in some cases, pre-existing anti-tumour T cell responses 8,9,21,22 ; (b) whereas α CTLA-4 treatment eliminates Tregs, promotes T cell priming, and renders the host more susceptible to autoimmunity 13,22,23…”
Self-citationSimpson, T. R., Li, F., Montalvo-Ortiz, W., Sepulveda, M. A., Bergerhoff, K., Arce, F., Roddie, C., Henry, J. Y., Yagita, H., Wolchok, J. D., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130579 · Cited by 1,472
Self-citationHuang, Y., Yuan, J., Righi, E., Kamoun, W. S., Ancukiewicz, M., Nezivar, J., Santosuosso, M., Martin, J. D., Martin, M. R., Vianello, F., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215397109 · Cited by 1,099
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Self-citationOncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
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“Moreover, there is growing evidence that targeting the tumor immune microenvironment may provide an effective therapeutic strategy (Quezada et al., 2011).”
Background
Metadata
- Authors
- Quezada, S. A., Peggs, K. S., Simpson, T. R., & Allison, J. P.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2011-04-13
- Volume
- 241
- Issue
- 1
- Pages
- 104-118
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1881296535
- Cited by
- 276
- References
- 212
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Quezada, S. A., Peggs, K. S., Simpson, T. R., & Allison, J. P. (2011). Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication. Immunological Reviews. https://doi.org/10.1111/j.1600-065x.2011.01007.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
