The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation
Open accessAbstract
Summary: The tumor necrosis factor (TNF) receptor superfamily member herpesvirus entry mediator (HVEM) (TNFRSF14) regulates T‐cell immune responses by activating both inflammatory and inhibitory signaling pathways. HVEM acts as both a receptor for the canonical TNF‐related ligands, LIGHT [lymphotoxin‐like, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for HVEM, a receptor expressed on T lymphocytes] and lymphotoxin‐α, and as a ligand for the immunoglobulin superfamily proteins BTLA (B and T lymphocyte attenuator) and CD160, a feature distinguishing HVEM from other immune regulatory molecules. The ability of HVEM to interact with multiple ligands in distinct configurations creates a functionally diverse set of intrinsic and bidirectional signaling pathways that control both inflammatory and inhibitory responses. The HVEM system is integrated into the larger LTβR and TNFR network through extensive shared ligand and receptor usage. Experimental mouse models and human diseases indicate that dysregulation of HVEM network may contribute to autoimmune pathogenesis, making it an attractive target for drug intervention.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., Hurchla, M. A., Zimmerman, N., Sim, J., Zang, X., et al. (2003) · Nature Immunology · doi:10.1038/ni944 · Cited by 883
Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry
Akhtar, J., & Shukla, D. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07402.x · Cited by 292
Association of Grb-2 and PI3K p85 with phosphotyrosile peptides derived from BTLA
Gavrieli, M., & Murphy, K. M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.036 · Cited by 85 · cited 1×
“Ligation of BTLA by HVEM resulted in the recruitment of SHP-1 and SHP-2 to the cytoplasmic tail of BTLA, providing a mechanism for limiting the stimulatory pathways activated by tyrosine kinases associated with T-cell (44, 45) and B-cell antigen receptors (46).”
BackgroundB and T Lymphocyte Attenuator Tempers Early Infection Immunity
Sun, Y., Brown, N. K., Ruddy, M. J., Miller, M. L., Lee, Y., Wang, Y., Murphy, K. M., Pfeffer, K., Chen, L., Kaye, J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801866 · Cited by 51
Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells
Wang, X. ‐., Chen, Y. ‐., Wang, Q., Ge, Y., Dai, Q., Yang, K. ‐., Fang‐Xie, Zhou, Y. ‐., Hu, Y. ‐., Mao, Y. ‐., et al. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2006.00710.x · Cited by 51
Cited by
Molecular mechanisms of T cell co-stimulation and co-inhibition
Chen, L., & Flies, D. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3405 · Cited by 3,114
Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4
Qin, S., Xu, L., Yi, M., Yu, S., Wu, K., & Luo, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1091-2 · Cited by 1,145
Genetics of diffuse large B-cell lymphoma
Pasqualucci, L., & Dalla-Favera, R. (2018) · Blood · doi:10.1182/blood-2017-11-764332 · Cited by 282
Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells
Boice, M., Salloum, D., Mourcin, F., Sanghvi, V., Amin, R., Oricchio, E., Jiang, M., Mottok, A., Denis-Lagache, N., Ciriello, G., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.032 · Cited by 257
BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection
Yu, X., Zheng, Y., Mao, R., Su, Z., & Zhang, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00617 · Cited by 83
Metadata
- Authors
- Steinberg, M. W., Cheung, T. C., & Ware, C. F.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2011-10-21
- Volume
- 244
- Issue
- 1
- Pages
- 169-187
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1480075263
- Cited by
- 243
- References
- 5
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation. https://app.cochat.ai/papers/10.1111/j.1600-065x.2011.01064.x
- The paper
- Steinberg, M. W., Cheung, T. C., & Ware, C. F. (2011). The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation. Immunological Reviews. https://doi.org/10.1111/j.1600-065x.2011.01064.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
