The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A genetic progression model of oral cancer: current evidence and clinical implications
Open accessAbstract
Based on recent genetic studies, we propose a progression model for the development of oral squamous cell carcinoma. In the initial phase, a stem cell acquires a genetic alteration; subsequently a patch is formed, a clonal unit consisting of the stem cell with its daughter cells that all share the DNA alteration. The next critical step is the conversion of a patch into an expanding field as a result of additional genetic alterations. This mucosal field replaces the normal epithelium and in the oral cavity such fields have been detected with dimensions of over 7 cm in diameter. Sometimes these fields are visible as leukoplakia. Ultimately, clonal selection leads to the development of carcinoma within this contiguous field of pre‐neoplastic cells. An important clinical implication of this model is that fields often remain after surgery of the primary tumor and may lead to new cancers, presently designated by clinicians as second primary tumors or local recurrences.
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Citations
Cites
Rules for Making Human Tumor Cells
Hahn, W. C., & Weinberg, R. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021902 · Cited by 951
Chromosome aberrations in solid tumors
Albertson, D. G., Collins, C., McCormick, F., & Gray, J. W. (2003) · Nature Genetics · doi:10.1038/ng1215 · Cited by 812
Zhang, W., Remenyik, E., Zelterman, D., Brash, D. E., & Wikonkal, N. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241353198 · Cited by 173
Cited by
Oral squamous cell carcinoma overview
Scully, C., & Bagan, J. (2009) · Oral Oncology · doi:10.1016/j.oraloncology.2009.01.004 · Cited by 494
Current Aspects on Oral Squamous Cell Carcinoma
Markopoulos, A. K. (2012) · The Open Dentistry Journal · doi:10.2174/1874210601206010126 · Cited by 489
Long-term treatment outcome of oral premalignant lesions
Holmstrup, P., Vedtofte, P., Reibel, J., & Stoltze, K. (2006) · Oral Oncology · doi:10.1016/j.oraloncology.2005.08.011 · Cited by 443
Profiling early head and neck cancer
Hunter, K. D., Parkinson, E. K., & Harrison, P. R. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1549 · Cited by 437
Smeets, S. J., Braakhuis, B. J. M., Abbas, S., Snijders, P. J. F., Ylstra, B., van de Wiel, M. A., Meijer, G. A., Leemans, C. R., & Brakenhoff, R. H. (2006) · Oncogene · doi:10.1038/sj.onc.1209275 · Cited by 255
Metadata
- Authors
- J. M. Braakhuis, B., René Leemans, C., & H. Brakenhoff, R.
- Venue
- Journal of Oral Pathology & Medicine
- Publisher
- Wiley
- Published
- 2004-06-16
- Volume
- 33
- Issue
- 6
- Pages
- 317-322
- ISSN
- 0300-9777 (ISSN-L)
- 0904-2512
- 1600-0714
- OpenAlex
- W1856235061
- Cited by
- 190
- References
- 3
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- J. M. Braakhuis, B., René Leemans, C., & H. Brakenhoff, R. (2004). A genetic progression model of oral cancer: current evidence and clinical implications. Journal of Oral Pathology & Medicine. https://doi.org/10.1111/j.1600-0714.2004.00225.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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