Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 287

The DOI matches its Crossref record.

Interaction Between Chemicals and Melanin

LARSSON, BENGT S.·1993·Pigment Cell Research
DOI 10.1111/j.1600-0749.1993.tb00591.x
Open this paper in CoChat — free account

Abstract

Various drugs and other chemicals, such as organic amines, metals, polycyclic aromatic hydrocarbons, etc., are bound to melanin and retained in pigmented tissues for long periods. The physiological significance of the binding is not evident, but it has been suggested that the melanin protects the pigmented cells and adjacent tissues by adsorbing potentially harmful substances, which then are slowly released in nontoxic concentrations. Long‐term exposure, on the other hand, may build up high levels of noxious chemicals, stored on the melanin, which ultimately may cause degeneration in the melanin‐containing cells, and secondary lesions in surrounding tissues. In the eye, e.g., and in the inner ear, the pigmented cells are located close to the receptor cells, and melanin binding may be an important factor in the development of some ocular and inner ear lesions. In the brain, neuromelanin is present in nerve cells in the extrapyramidal system, and the melanin affinity of certain neurotoxic agents may be involved in the development of parkinsonism, and possibly tardive dyskinesia. In recent years, various carcinogenic compounds have been found to accumulate selectively in the pigment cells of experimental animals, and there are many indications of a connection between the melanin affinity of these agents and the induction of malignant melanoma.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1600-0749.1993.tb00591.x

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 83

  1. 10.1093/carcin/12.10.1963 · doi:10.1093/carcin/12.10.1963
  2. 10.1016/0002-9394(80)90001-X · DOI
  3. Anders A., 1991, Discrimination of initiating and promoting carcinogens in fish, Ann. Rech. Vet., 22, 273
  4. 10.1007/978-3-642-82641-2_7 · doi:10.1007/978-3-642-82641-2_7
  5. 10.1016/0024-3205(85)90185-7 · DOI
  6. 10.1016/0361-9230(83)90218-6 · DOI
  7. Barthel E., 1985, Erhöhte Mortalität an Ösophaguskrebs, Magenkrebs und Hautmelanom bei Pestizid‐exponierten Schädlingsbekämpfern in der DDR, Arch. Geschwulstforsch., 55, 481
  8. Bergman K., 1985, Autoradiographic distribution of 14C‐labeled 3H‐imidazo(4,5‐f)quinoline‐2‐amines in mice, Cancer Res., 45, 1351
  9. Berkelhammer J., 1982, Development of a new melanoma model in C57BL/6 mice, Cancer Res., 42, 3157
  10. 10.1016/0378-4274(88)90106-3 · doi:10.1016/0378-4274(88)90106-3
  11. 10.1093/carcin/4.10.1291 · doi:10.1093/carcin/4.10.1291
  12. 10.1093/carcin/10.8.1529 · doi:10.1093/carcin/10.8.1529
  13. 10.1056/NEJM196609292751303 · DOI
  14. Carlsson A., 1970, L‐Dopa and parkinsonism, 205
  15. 10.1016/0006-291X(84)91293-2 · DOI · Paper page
  16. Chiueh C.C., 1983, N‐methyl‐4‐phenyl‐1,2,3,6‐tetra‐hydropyridine, a parkinsonian syndrome causing agent in man and monkey, produces different effects in guinea pig and rat, Pharmacologist, 25, 131
  17. 10.1111/j.1600-0447.1970.tb02097.x · DOI
  18. 10.1126/science.3080808 · DOI · Paper page
  19. 10.1007/BF00316582 · doi:10.1007/bf00316582
  20. 10.1007/BF01922819 · DOI
  21. 10.1001/archotol.1975.00780320043010 · doi:10.1001/archotol.1975.00780320043010
  22. 10.1038/bjc.1979.80 · doi:10.1038/bjc.1979.80
  23. 10.1111/j.1600-0773.1981.tb00883.x · doi:10.1111/j.1600-0773.1981.tb00883.x
  24. 10.1111/j.1524-4725.1988.tb03373.x · DOI
  25. 10.1021/ja00480a044 · DOI · Paper page
  26. Goerttler K., 1980, Two‐stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12‐dimethyl‐benz(a)anthracene and topical promotion with 12‐o‐tetradecanoyl‐phorbol‐13‐acetate, Cancer Res., 40, 155
  27. Goodman L.S., 1985, The pharmacological basis of therapeutics, 1839
  28. Greiner A.C., 1964, Skin pigmentation and corneal and lens opacities with prolonged chlorpromazine therapy, Canad. Med. Ass. J., 90, 663
  29. 10.1016/0378-4274(80)90095-8 · doi:10.1016/0378-4274(80)90095-8
  30. 10.1016/0014-2999(84)90521-1 · DOI
  31. 10.1016/0024-3205(86)90279-1 · doi:10.1016/0024-3205(86)90279-1
  32. 10.1126/science.6610213 · DOI · Paper page
  33. Heldaas S.S., 1987, Incidence of cancer among vinyl chloride and polyvinyl chloride workers: Further evidence for an association with malignant melanoma, Br. J. Ind. Med., 44, 278
  34. 10.1038/235050a0 · DOI · Paper page
  35. 10.1016/0304-4165(86)90146-7 · DOI · Paper page
  36. 10.1016/0300-483X(86)90148-4 · doi:10.1016/0300-483x(86)90148-4
  37. 10.1111/php.1990.51.6.765 · DOI
  38. 10.1016/0304-3940(84)90293-3 · DOI · Paper page
  39. 10.1016/0014-4835(77)90102-6 · DOI
  40. 10.1111/j.1748-1716.1978.tb06303.x · DOI
  41. Larsson B., 1979, Mechanisms of accumulation of foreign substances in melanin. Binding to preformed melanin and incorporation into growing melanin, Acta Universitatis Upsaliensis, 43, 1
  42. 10.1016/0006-2952(79)90326-5 · DOI
  43. 10.1111/j.1600-0773.1981.tb01620.x · doi:10.1111/j.1600-0773.1981.tb01620.x
  44. 10.1038/bjc.1982.238 · doi:10.1038/bjc.1982.238
  45. 10.1016/0278-6915(88)90228-1 · doi:10.1016/0278-6915(88)90228-1
  46. Larsson B.S., 1989, Retention of carcinogens in pigmented tissues due to melanin affinity. Abstract (2nd Meeting of the ESPCR, Uppsala, Sweden, 1989), ESPCR Bulletin, 43
  47. 10.1097/00008390-199106000-00002 · doi:10.1097/00008390-199106000-00002
  48. 10.1111/j.1600-0773.1972.tb03310.x · DOI
  49. Lindquist N.G., 1973, Accumulation of drugs on melanin, Acta Radiol. (Diagn.) (Stockh.), 1
  50. 10.1111/j.1600-0773.1986.tb00149.x · doi:10.1111/j.1600-0773.1986.tb00149.x
  51. 10.1111/j.1600-0749.1987.tb00403.x · DOI
  52. 10.1016/0304-3940(88)90002-X · DOI
  53. 10.1111/j.1600-0773.1983.tb03446.x · DOI
  54. 10.1111/j.1600-0773.1984.tb01975.x · DOI
  55. 10.1111/j.1600-0773.1988.tb00914.x · doi:10.1111/j.1600-0773.1988.tb00914.x
  56. Lydén‐Sokolowski A., 1990, Melanin binding of MPTP and related substances, and manganese: Possible connection with parkinsonism, Acta Universitatis Upsaliensis, 63, 1
  57. Lyttkens L., 1984, Local anaesthetics and tinnitus, Proposed peripheral mechanism of action of lidocaine. ORL, 46, 17
  58. 10.1038/bjc.1982.307 · DOI · Paper page
  59. Magnani C., 1987, Occupation and five cancers: A case‐control study using death certificates, Br. J. Ind. Med., 44, 769
  60. 10.1038/311464a0 · DOI · Paper page
  61. Marsden C.D., 1969, Pigments in pathology, 395
  62. 10.1212/WNL.17.2.128 · DOI · Paper page
  63. 10.1055/s-2007-1008161 · doi:10.1055/s-2007-1008161
  64. 10.1111/j.1600-0773.1983.tb03415.x · doi:10.1111/j.1600-0773.1983.tb03415.x
  65. 10.1016/0304-4165(90)90038-X · DOI
  66. 10.3109/03602537808993791 · DOI
  67. 10.1097/00043764-197811000-00003 · doi:10.1097/00043764-197811000-00003
  68. Potts A.M., 1962, The concentration of phenothiazines in the eye of experimental animals, Invest. Ophthalmol. Vis. Sci., 1, 522
  69. Potts A.M., 1964, The reaction of uveal pigment in vitro with polycyclic compounds, Invest. Ophthalmol. Vis. Sci., 3, 405
  70. Prota G., 1992, Melanins and melanogenesis, 290
  71. 10.1007/BF01955422 · doi:10.1007/bf01955422
  72. 10.1016/S0006-291X(86)80483-1 · DOI · Paper page
  73. 10.1176/ajp.139.3.341 · doi:10.1176/ajp.139.3.341
  74. Rodier J., 1955, Manganese poisoning in Moroccan miners, Brit. J. Ind. Med., 12, 21
  75. 10.1016/0006-2952(72)90350-4 · doi:10.1016/0006-2952(72)90350-4
  76. 10.1001/archneur.1966.00470100025003 · doi:10.1001/archneur.1966.00470100025003
  77. 10.1016/0006-2952(82)90612-8 · doi:10.1016/0006-2952(82)90612-8
  78. 10.1002/ana.410320712 · DOI
  79. Tammela M., 1985, Tissue localization of some organic and inorganic cations. Binding to melanin and cartilage, Acte Universitatis Upsaliensis, 111, 1
  80. Thomas T.L., 1979, Mortality among workers employed in the pharmaceutical industry: A preliminary investigation, J. Occup. Med., 21, 619
  81. 10.1111/j.1748-1716.1981.tb06806.x · DOI
  82. 10.1111/j.1600-0773.1982.tb01006.x · doi:10.1111/j.1600-0773.1982.tb01006.x
  83. 10.1016/0014-4827(66)90441-1 · doi:10.1016/0014-4827(66)90441-1

Cited by

See all 287

Metadata

Authors
LARSSON, B. S.
Venue
Pigment Cell Research
Publisher
Wiley
Published
1993-06
Volume
6
Issue
3
Pages
127-133
ISSN
  • 0893-5785 (ISSN-L)
  • 1600-0749
DOI
10.1111/j.1600-0749.1993.tb00591.x
OpenAlex
W2005496382
Cited by
287
References
0
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4805 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Interaction Between Chemicals and Melanin. https://app.cochat.ai/papers/10.1111/j.1600-0749.1993.tb00591.x
The paper
LARSSON, B. S. (1993). Interaction Between Chemicals and Melanin. Pigment Cell Research. https://doi.org/10.1111/j.1600-0749.1993.tb00591.x

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.