The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP + Binds to Neuromelanin
Abstract
Methylphenyltetrahydropyridine (MPTP) selectively destroys neuronal cell bodies in the melanin-containing substantia nigra of humans and other primates. We show that methylphenylpyridine (MPP + ), an active metabolite of MPTP which is accumulated intraneuronally by the catecholamine uptake system, binds with high affinity to melanin and neuromelanin. MPP + bound intracellularly to neuromelanin may be released gradually, resulting in subsequent damage to the neurons of the substantia nigra.
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Cites
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Metadata
- Authors
- D'Amato, R. J., Lipman, Z. P., & Snyder, S. H.
- Venue
- Science
- Published
- 1986-02-28
- Volume
- 231
- Issue
- 4741
- Pages
- 987-989
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000956059
- Cited by
- 296
- References
- 19
- FWCI
- 29.12
- Type
- journal article
- Language
- en
- Open access
- closed
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