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Cited by 257Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsDental Research and COVID-19

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Subgingival biodiversity in subjects with uncontrolled type‐2 diabetes and chronic periodontitis

Casarin, R. C. V., Barbagallo, A., Meulman, T., Santos, V. R., Sallum, E. A., Nociti, F. H., Duarte, P. M., Casati, M. Z., Gonçalves, R. B.·2013·Journal of Periodontal Research
DOI 10.1111/j.1600-0765.2012.01498.x
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Abstract

Background and Objective: There is a bidirectional relationship between periodontal disease and type‐2 diabetes mellitus (DM). Inflammatory mediators may negatively affect glycemic control, and increased glucose levels and resultant glycation end‐products may alter the host response against bacterial infection. However, no agreement has been reached regarding the effect of DM on periodontal subgingival microbiota. Therefore, the purpose of the present study was to compare the subgingival biodiversity in deep periodontal pockets of subjects with chronic periodontitis and either uncontrolled type‐2 diabetes or no diabetes using 16S rRNA gene cloning and sequencing. Material and methods: Twelve subjects with uncontrolled type‐2 diabetes (glycated hemoglobin > 8%) and eleven nondiabetic subjects presenting severe and generalized chronic periodontitis were selected. Subgingival biofilm from periodontal pockets > 5 mm were assessed using the 16S rRNA gene cloning and sequencing technique. Results: Significant differences were observed in subgingival microbiota between diabetic and nondiabetic subjects. Diabetic subjects presented higher percentages of total clones of TM7, Aggregatibacter, Neisseria, Gemella, Eikenella, Selenomonas, Actinomyces, Capnocytophaga, Fusobacterium, Veillonella and Streptococcus genera, and lower percentages of Porphyromonas, Filifactor, Eubacterium, Synergistetes, Tannerella and Treponema genera than nondiabetic individuals (p < 0.05). Moreover, some phylotypes, such as Fusobacterium nucleatum, Veillonella parvula, V. dispar and Eikenella corrodens were detected significantly more often in diabetic subjects than in nondiabetic subjects (p < 0.05). Conclusion: Subjects with uncontrolled type‐2 diabetes and chronic periodontitis presented significant dissimilarities in subgingival biodiversity compared with nondiabetic subjects.

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Crossref · 10.1111/j.1600-0765.2012.01498.x

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Metadata

Authors
Casarin, R. C. V., Barbagallo, A., Meulman, T., Santos, V. R., Sallum, E. A., Nociti, F. H., Duarte, P. M., Casati, M. Z., & Gonçalves, R. B.
Affiliations
  • Universidade Estadual de Campinas (UNICAMP) (BR)
  • Université Laval (CA)
  • Guarulhos University (BR)
Corresponding author
Casarin, R. C. V.
ORCID
Venue
Journal of Periodontal Research
Publisher
Wiley
Published
2012-07-04
Volume
48
Issue
1
Pages
30-36
ISSN
  • 0022-3484 (ISSN-L)
  • 1600-0765
DOI
10.1111/j.1600-0765.2012.01498.x
OpenAlex
W2149358775
Cited by
256
References
42
Citations by year
2026: 9 · 2025: 25 · 2024: 30 · 2023: 25 · 2022: 33 · 2021: 23 · 2020: 28 · 2019: 15 · 2018: 18 · 2017: 17 · 2016: 6 · 2015: 9 · 2014: 13 · 2013: 2 · 2012: 3
FWCI
10.38
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Periodontal Research (publishedVersion)
  • PubMed (publishedVersion)
  • Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
  • UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords
type 2 diabetes, chronic periodontitis, subgingival microbiota, periodontal pockets, subgingival plaque, Fusobacterium nucleatum, Veillonella, Eikenella corrodens, Porphyromonas, Aggregatibacter, TM7, glycemic control
MeSH terms
Actinobacillus, Actinomyces, Adult, Bacteria, Bacteroides, Capnocytophaga, Diabetes Mellitus, Type 2, Eubacterium, Female, Fusobacterium, Gingiva, Gram-Negative Anaerobic Bacteria, Humans, Male, Neisseria, Periodontal Pocket, RNA, Bacterial, RNA, Ribosomal, 16S, Streptococcus, Treponema, Veillonella, Eikenella, Periodontal Attachment Loss, Porphyromonas, Biofilms, Selenomonas, Biodiversity, Chronic Periodontitis, Gemella

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