The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
CHOLINERGIC DYSFUNCTION IN DEPRESSION
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Cholinergic hyperactivity plays a role in the pathophysiology of depression and can exacerbate depression-like symptoms in patients and controls.
“First, cholinergic hyperactivity plays a role in the pathophysiology of depression (2–4) and can exacerbate depression-like symptoms in patients and controls (4–6).”
From Persistent β 2 *-Nicotinic Acetylcholinergic Receptor Dysfunction in Major Depressive Disorder (2012) · cites this paper as [6]
Citations
Cites
Depression: The predisposing influence of stress
Anisman, H., & Zacharko, R. M. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00010633 · Cited by 436
CSF and Urinary Biogenic Amines and Metabolites in Depression and Mania
Koslow, S. H. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790080081011 · Cited by 313
Sitaram, N., Nürnberger, J. I., Gershon, E. S., & Gillin, J. C. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.5.571 · Cited by 241
Potentiation of antidepressant effects by L-triiodothyronine in tricyclic nonresponders
Goodwin, F. K., Prange, A. J., Post, R. M., Muscettola, G., & Lipton, M. A. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.1.34 · Cited by 231
Mechanisms underlying sensitivity to organophosphorus anticholinesterase compounds
Russell, R. W., & Overstreet, D. H. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90008-6 · Cited by 152
Self-citationMotor Activity and Affective Illness
Wolff, E. A. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790260086010 · Cited by 151
Chemical stimulation of the brain: effect on adrenal corticoid release
Hp, K., & Krieger, D. T. (1970) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1970.218.6.1632 · Cited by 130
The Cholinergic Rapid Eye Movement Sleep Induction Test With RS-86
Berger, M. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810050035006 · Cited by 127
Janowsky, D. S., & Risch, S. C. (1984) · Drug Development Research · doi:10.1002/ddr.430040202 · Cited by 126
Self-citationModulation of corticotrophin-releasing factor release from hypothalamic synaptosomes
Edwardson, J. A., & Bennett, G. W. (1974) · Nature · doi:10.1038/251425a0 · Cited by 117
Overstreet, D. H., Russell, R. W., Crocker, A. D., & Schiller, G. D. (1984) · Brain Research · doi:10.1016/0006-8993(84)91044-8 · Cited by 78
Self-citationGenetic and pharmacological models of cholinergic supersensitivity and affective disorders
Overstreet, D. H., Russell, R. W., Crocker, A. D., Gillin, J. C., & Janowsky, D. S. (1988) · Cellular and Molecular Life Sciences · doi:10.1007/bf01958920 · Cited by 78
Self-citationDilsaver, S. C., & Greden, J. F. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90028-6 · Cited by 73
Nürnberger, J. I., Jimerson, D. C., Simmons-Alling, S., Tamminga, C. A., Nadi, N. S., Lawrence, D., Sitaram, N., Gillin, J. C., & Gershon, E. S. (1983) · Psychiatry Research · doi:10.1016/0165-1781(83)90043-4 · Cited by 70
The association of supersensitive cholinergic rem-induction and affective illness within pedigrees
Sitaram, N., Dubé, S., Keshavan, M. S., Davies, A., & Reynal, P. (1987) · Journal of Psychiatric Research · doi:10.1016/0022-3956(87)90097-5 · Cited by 54
Measuring cholinergic sensitivity: I. Arecoline effects in bipolar patients
Nürnberger, J. I., Berrettini, W. H., Mendelson, W. B., Sack, D. A., & Gershon, E. S. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90221-7 · Cited by 41
Enhanced benzodiazepine responsiveness in rats with increased cholinergic function
Pepe, S., Overstreet, D. H., & Crocker, A. D. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90304-8 · Cited by 35
Self-citationSteiner, F. A. (1968) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00592634 · Cited by 35
Martin, J. R., Overstreet, D. H., Driscoll, P., et al. (1981) · Psychopharmacology · doi:10.1007/bf00431646 · Cited by 30
Self-citationPhysostigmine-induced epinephrine release in patients with affective disorder
Janowsky, D. S., Sc, R., Ziegler, M. G., Gillin, J. C., Huey, L. Y., & Rausch, J. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.7.919 · Cited by 27
Self-citationRat lung cholinergic receptor: characterization and regulation by corticosteroids
Marquardt, D. L., Motulsky, H. J., & Wasserman, S. I. (1982) · Journal of Applied Physiology · doi:10.1152/jappl.1982.53.3.731 · Cited by 24
Increased uptake of [3H]choline by rat superior cervical ganglion: An effect of dexamethasone
Sze, P. Y., Marchi, M., Towle, A. C., et al. (1983) · Neuropharmacology · doi:10.1016/0028-3908(83)90094-1 · Cited by 17
Moises, H. W., Beringe, B., & M�ller, W. E. (1988) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00449909 · Cited by 9
Human Brain Receptor Distribution
Frey, K. A., Agranoff, B. W., Young, A. B., et al. (1986) · Science · doi:10.1126/science.3704652 · Cited by 7
Cholinergic Mechanisms in Mood: Neuroendocrine Aspects
Janowsky, D. S., Golden, R. N., & Risch, S. C. (1988) · Current topics in neuroendocrinology · doi:10.1007/978-3-642-72738-2_8 · Cited by 6
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Effect of nicotine and nicotinic receptors on anxiety and depression
Picciotto, M. R., Brunzell, D. H., & Caldarone, B. J. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00006 · Cited by 483
Pharmacological validation of the chronic mild stress model of depression
Papp, M., Moryl, E., & Willner, P. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00697-4 · Cited by 205
Scopolamine produces larger antidepressant and antianxiety effects in women than in men
Furey, M. L., Khanna, A., Hoffman, E. M., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.131 · Cited by 138
Persistent β 2 *-Nicotinic Acetylcholinergic Receptor Dysfunction in Major Depressive Disorder
Saricicek, A., Esterlis, I., Maloney, K. H., Mineur, Y. S., Ruf, B. M., Muralidharan, A., Chen, J. I., Cosgrove, K. P., Kerestes, R., Ghose, S., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11101546 · Cited by 118
Maes, M., Mihaylova, I., Kubera, M., Leunis, J.-C., Twisk, F. N. M., & Geffard, M. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9316-8 · Cited by 52
Metadata
- Authors
- Janowsky, D. S., & Overstreet, D. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Pharmacology & Toxicology
- Publisher
- Wiley
- Published
- 1990-03
- Volume
- 66
- Issue
- s3
- Pages
- 100-111
- ISSN
- 0901-9928 (ISSN-L)
- OpenAlex
- W2028747586
- Cited by
- 33
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2018: 2 · 2016: 1 · 2015: 2 · 2014: 4 · 2012: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cholinergic dysfunction, depression, acetylcholine, cholinergic system
- MeSH terms
- Animals, Autonomic Nervous System Diseases, Depressive Disorder, Humans, Parasympathetic Nervous System
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