Oral Vanadyl Sulphate Does not Affect Blood Cells, Viscosity or Biochemistry in Humans
Open accessAbstract
Abstract: Vanadyl sulphate (VOSO 4) is used to improve performance in weight training athletes. Concerns about its safety have arisen because vanadium compounds may cause anaemia and changes in the leukocyte system. In this study, the effects of oral VOSO 4 (0.5 mg/kg/day) on haematological indices (red and white cell and platelet counts, red cell mean cell volume and haemoglobin level), blood viscosity (haematocrit, plasma viscosity and blood viscosity at 10s−1 and 100s−1 shear rates) and biochemistry (lipids and indices of liver and kidney function) were investigated in a twelve week, double blind, placebo controlled trial in 31 weight training athletes. Blood viscosity was evaluated at 0, 2, 4, 8 and 12 weeks and haematological indices and biochemistry were measured before and at the end of treatment. Both the treatment group and placebo group showed increases in haematocrit (3.3‐3.6%) and blood viscosity (9‐11% at 100s−1 shear; 35‐38% at 10s−1 shear) but there were no significant effects of treatment. Similarly there were no treatment effects on haematological indices and biochemistry. Concerns about the adverse effects of oral vanadyl sulphate on blood are not supported by the results of this trial.
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No studies are available that support the ability of vanadyl sulfate supplementation to impact strength or muscle mass in non-diabetic individuals who are currently resistance training.
“However, no studies are available that support the ability of vanadyl sulfate supplementation to impact strength or muscle mass in non-diabetic individuals who are currently resistance training [412, 413].”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [413]
The Methods (p. 1) confirm that participants were non-diabetic weight-training athletes, and the Discussion (p. 3) reports no effect on body weight. But this paper does not report strength or muscle-mass outcomes or establish that no studies support an effect; its introduction (p. 1) directs readers to an earlier paper for body-composition and performance results. Searched for strength, muscle mass, body composition, and performance findings. (LLM, conf=0.72)
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ISSN exercise & sports nutrition review update: research & recommendations
Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945 · see citing works
ISSN exercise & sport nutrition review: research & recommendations
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ISSN Exercise & Sport Nutrition Review: Research & Recommendations
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- Authors
- Fawcett, J. P., Farquhar, S. J., Thou, T., & Shand, B. I.
- Affiliations
- University of Otago (NZ)
- Christchurch Hospital (NZ)
- Corresponding author
- Fawcett, J. P.
- Venue
- Pharmacology & Toxicology
- Publisher
- Wiley
- Published
- 1997-04
- Volume
- 80
- Issue
- 4
- Pages
- 202-206
- ISSN
- 0901-9928 (ISSN-L)
- OpenAlex
- W2039117027
- Cited by
- 84
- References
- 28
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 4 · 2021: 2 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 4
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmacology & Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Otago Medical Research Foundation
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Vanadium and Halogenation Chemistry
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- vanadyl sulfate, blood viscosity, hematological parameters, hematocrit, plasma viscosity, anemia, liver function, renal function, lipid profile, supplement safety, shear rate
- MeSH terms
- Adult, Blood Cell Count, Blood Cells, Blood Chemical Analysis, Blood Pressure, Blood Viscosity, Body Weight, Female, Hematocrit, Humans, Hypoglycemic Agents, Male, Weight Lifting, Vanadium Compounds
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