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Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies
Abstract
Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. There are also experimental and clinical data supporting an analgesic role of melatonin. In experimental studies, melatonin shows potent analgesic effects in a dose-dependent manner. In clinical studies, melatonin has been shown to have analgesic benefits in patients with chronic pain (fibromyalgia, irritable bowel syndrome, migraine). The physiologic mechanism underlying the analgesic actions of melatonin has not been clarified. The effects may be linked to G(i) -coupled melatonin receptors, to G(i) -coupled opioid μ-receptors or GABA-B receptors with unknown downstream changes with a consequential reduction in anxiety and pain. Also, the repeated administration of melatonin improves sleep and thereby may reduce anxiety, which leads to lower levels of pain. In this paper, we review the current evidence regarding the analgesic properties of melatonin in animals and humans with chronic pain.
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Cited by
Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction
Hardeland, R. (2012) · The Scientific World Journal · doi:10.1100/2012/640389 · Cited by 173
Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder
Lalanne, S., Fougerou-Leurent, C., Anderson, G. M., Schroder, C. M., Nir, T., Chokron, S., Delorme, R., Claustrat, B., Bellissant, E., Kermarrec, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031490 · Cited by 90
Efficacy of Melatonin in prevention of radiation-induced oral mucositis: A randomized clinical trial
Elsabagh, H. H., Moussa, E., Mahmoud, S. A., Elsaka, R. O., & Abdelrahman, H. (2020) · Oral Diseases · doi:10.1111/odi.13265 · Cited by 65
Danilov, A. B., Danilov, A. B., Kurushina, O. V., Shestel, E. A., Zhivolupov, S. A., & Latysheva, N. V. (2020) · Pain and Therapy · doi:10.1007/s40122-020-00207-y · Cited by 12
Metadata
- Authors
- Wilhelmsen, M., Amirian, I., Reiter, R. J., Rosenberg, J., & Gögenur, I.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2011-05-26
- Volume
- 51
- Issue
- 3
- Pages
- 270-277
- ISSN
- 0742-3098 (ISSN-L)
- OpenAlex
- W1493696659
- Cited by
- 214
- References
- 0
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wilhelmsen, M., Amirian, I., Reiter, R. J., Rosenberg, J., & Gögenur, I. (2011). Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. Journal of Pineal Research. https://doi.org/10.1111/j.1600-079x.2011.00895.x
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