Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction

Phototransduction by retinal ganglion cells that set the circadian clock

Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629 · see citing works

Hypothalamic regulation of sleep and circadian rhythms

Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804 · see citing works

A functional analysis of circadian pacemakers in nocturnal rodents

Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417856 · Cited by 2,129 · see citing works

Oxidative damage and mitochondrial decay in aging.

Shigenaga, M. K., Hagen, T. M., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10771 · Cited by 2,055 · see citing works

Regulation of antioxidant enzymes: a significant role for melatonin

Rodrı́guez, C., Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,990 · see citing works

Light Suppresses Melatonin Secretion in Humans

Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Markey, S. P. (1980) · Science · doi:10.1126/science.7434030 · Cited by 1,913 · see citing works

Circadian integration of metabolism and energetics

Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910 · see citing works

Melatonin : a potent, endogenous hydroxyl radical scavenger

Tan, D. (1993) · Endocrine Journal · Cited by 1,659 · see citing works

A functional analysis of circadian pacemakers in nocturnal rodents: V. Pacemaker structure: A clock for all seasons

Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology ? A · doi:10.1007/bf01417860 · Cited by 1,636 · see citing works

Melatonin as a natural ally against oxidative stress: a physicochemical examination

Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,154 · see citing works

Cold Spring Harbor Symposia on Quantitative Biology.

Berg, H. (1989) · Journal of Electroanalytical Chemistry · doi:10.1016/0022-0728(89)87283-3 · Cited by 1,152 · see citing works

The basic physiology and pathophysiology of melatonin

Claustrat, B., Brun, J., & Chazot, G. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.08.001 · Cited by 951 · see citing works

Sleep spindles: an overview

Gennaro, L. D., & Ferrara, M. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0252 · Cited by 925 · see citing works

Chronic Inflammation and Oxidative Stress as a Major Cause of Age- Related Diseases and Cancer

Khansari, N., Shakiba, Y., & Mahmoudi, M. (2009) · Recent Patents on Inflammation & Allergy Drug Discovery · doi:10.2174/187221309787158371 · Cited by 922 · see citing works

Melatonin: Nature’s most versatile biological signal?

Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875 · see citing works

Melatonin—A pleiotropic, orchestrating regulator molecule

Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843 · see citing works

Functional MT1 and MT2 Melatonin Receptors in Mammals

Dubocovich, M. L., & Markowska, M. (2005) · Endocrine · doi:10.1385/endo:27:2:101 · Cited by 816 · see citing works

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities: A Randomized Controlled Trial

Riemersma-van der Lek, R. F. (2008) · JAMA · doi:10.1001/jama.299.22.2642 · Cited by 803 · see citing works

The dark side of light at night: physiological, epidemiological, and ecological consequences

Navara, K. J., & Nelson, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00473.x · Cited by 795 · see citing works

A functional analysis of circadian pacemakers in nocturnal rodents

Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417859 · Cited by 765 · see citing works

Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve

Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992) · Chronobiology International · doi:10.3109/07420529209064550 · Cited by 693 · see citing works

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 670 · see citing works

Circadian genes, rhythms and the biology of mood disorders

McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works

A Review of the Multiple Actions of Melatonin on the Immune System

Carrillo‐Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 664 · see citing works

REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance

Bubenik, G. A. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020107915919 · Cited by 655 · see citing works

Melatonin as a chronobiotic

Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629 · see citing works

Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.

Reiter, R. J., Tan, D., Mayo, J. C., Sainz, R. M., León, J., & Czarnocki, Z. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3637 · Cited by 623 · see citing works

Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback

Fuller, P. M., Gooley, J. J., & Saper, C. B. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406294627 · Cited by 596 · see citing works

Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin

Tan, D., Manchester, L. C., Hardeland, R., López‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02111.x · Cited by 541 · see citing works

Circadian Rhythm Sleep Disorders: Part II, Advanced Sleep Phase Disorder, Delayed Sleep Phase Disorder, Free-Running Disorder, and Irregular Sleep-Wake Rhythm

Sack, R. L., Auckley, D. H., Auger, R. R., Carskadon, M. A., Wright, K. P., Vitiello, M. V., & Zhdanova, I. V. (2007) · SLEEP · doi:10.1093/sleep/30.11.1484 · Cited by 530 · see citing works

Self-reported sleep disturbance as a prodromal symptom in recurrent depression

Perlis, M. L., Giles, D. E., Buysse, D. J., Tu, X. M., & Kupfer, D. J. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(96)01411-5 · Cited by 523 · see citing works

The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways

Millan, M. J., Gobert, A., Lejeune, F., Dekeyne, A., Newman‐Tancredi, A., Pasteau, V., Rivet, J., & Cussac, D. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051797 · Cited by 516 · see citing works

Entrainment of free-running circadian rhythms by melatonin in blind people

Sack, R. L., Brandes, R. W., Kendall, A. R., & Lewy, A. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010123431503 · Cited by 490 · see citing works

DNA damage, cellular senescence and organismal ageing: causal or correlative?

Chen, J.-H., Hales, C. N., & Ozanne, S. E. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm681 · Cited by 481 · see citing works

Melatonin-Immune System Relationships

Guerrero, J. M., & Reiter, R. J. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394335 · Cited by 476 · see citing works

Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance

Carrillo‐Vico, A., Calvo, J. R., Abreu, P. M., Lardone, P. J., García‐Mauriño, S., Reiter, R. J., & Guerrero, J. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0694fje · Cited by 457 · see citing works

Mammalian melatonin receptors: molecular biology and signal transduction

von Gall, C., Stehle, J. H., & Weaver, D. R. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0581-4 · Cited by 455 · see citing works

Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

Hardeland, R., Madrid, J. A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00934.x · Cited by 449 · see citing works

Spectral Responses of the Human Circadian System Depend on the Irradiance and Duration of Exposure to Light

Gooley, J. J., Rajaratnam, S. M. W., Brainard, G. C., Kronauer, R. E., Czeisler, C. A., & Lockley, S. W. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000741 · Cited by 447 · see citing works

An efficacy, safety, and dose–response study of Ramelteon in patients with chronic primary insomnia

ERMAN, M., SEIDEN, D., ZAMMIT, G., SAINATI, S., & ZHANG, J. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2005.09.004 · Cited by 434 · see citing works

Circadian rhythm abnormalities in totally blind people: incidence and clinical significance

Sack, R. L., Lewy, A. J., Blood, M. L., KEITH, L. D., & Nakagawa, H. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.1.1619000 · Cited by 408 · see citing works

Free Radical‐Mediated Molecular Damage

Reiter, R. J., Acuña-Castroviejo, D., Tan, D. X., & Burkhardt, S. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03627.x · Cited by 398 · see citing works

Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat1

Wolden‐Hanson, T., Mitton, D. R., McCants, R. L., Yellon, S. M., Wilkinson, C. W., Matsumoto, A. M., & Rasmussen, D. D. (2000) · Endocrinology · doi:10.1210/endo.141.2.7311 · Cited by 390 · see citing works

Human Melatonin Suppression by Light is Intensity Dependent

Mclntyre, I. M., Norman, T. R., Burrows, G. D., & Armstrong, S. M. (1989) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1989.tb00412.x · Cited by 389 · see citing works

Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity

Pamplona, R. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.07.003 · Cited by 387 · see citing works

Melatonin as a Chronobiotic / Anticancer Agent: Cellular, Biochemical, and Molecular Mechanisms of Action and their Implications for Circadian-Based Cancer Therapy

Blask, D. E., Sauer, L. A., & Dauchy, R. T. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394407 · Cited by 381 · see citing works

Minireview: Entrainment of the Suprachiasmatic Clockwork in Diurnal and Nocturnal Mammals

Challet, É. (2007) · Endocrinology · doi:10.1210/en.2007-0804 · Cited by 341 · see citing works

Night Shift Work and the Risk of Endometrial Cancer

Viswanathan, A. N., Hankinson, S. E., & Schernhammer, E. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2485 · Cited by 338 · see citing works

Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials

Korkmaz, A., Reiter, R. J., Topal, T., Manchester, L. C., Öter, Ş., & Tan, D. (2009) · Molecular Medicine · doi:10.2119/molmed.2008.00117 · Cited by 319 · see citing works

Sleep disorders and melatonin rhythms in elderly people

Haimov, I., Laudon, M., Zisapel, N., Souroujon, M. C., Nof, D., Shlitner, A., Herer, P., Tzischinsky, O., & Lavie, P. (1994) · BMJ · doi:10.1136/bmj.309.6948.167 · Cited by 315 · see citing works

Circadian photoreception: ageing and the eye's important role in systemic health

Turner, P. L., & Mainster, M. A. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2008.141747 · Cited by 315 · see citing works

Melatonin, endocrine pancreas and diabetes

Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00519.x · Cited by 309 · see citing works

Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide

de la Torre, J. C., & Stefano, G. B. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00043-6 · Cited by 307 · see citing works

The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates

Huether, G. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923948 · Cited by 306 · see citing works

Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype¹

Liu, R.-Y., Zhou, J.-N., van Heerikhuize, J., Hofman, M. A., & Swaab, D. F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5394 · Cited by 304 · see citing works

Clinical Uses of Melatonin: Evaluation of Human Trials

Sanchez-Barcelo, E. J., Mediavilla, M. D., Tan, D. X., & Reiter, R. J. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791233689 · Cited by 301 · see citing works

Melatonin in mood disorders

Srinivasan, V., Smits, M., Spence, W., Lowe, A. D., Kayumov, L., Pandi-Perumal, S. R., Parry, B., & Cardinali, D. P. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970600571822 · Cited by 292 · see citing works

Distinct Contributions of Rod, Cone, and Melanopsin Photoreceptors to Encoding Irradiance

Lall, G. S., Revell, V. L., Momiji, H., al Enezi, J., Altimus, C. M., Güler, A. D., Aguilar, C., Cameron, M. A., Allender, S., Hankins, M. W., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.037 · Cited by 289 · see citing works

A Genomewide Association Study of Citalopram Response in Major Depressive Disorder

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Melatonin administration can entrain the free-running circadian system of blind subjects

Lockley, S. W., Skene, D. J., James, K., Thapan, K., Wright, J., & Arendt, J. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.164r001 · Cited by 284 · see citing works

Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity

Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281 · see citing works

Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer’s disease

Wu, Y., & Swaab, D. F. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.010 · Cited by 280 · see citing works

The chronobiology, etiology and pathophysiology of obesity

Garaulet, M., Ordovás, J. M., & Madrid, J. A. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.118 · Cited by 279 · see citing works

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

López, A., García, J. A., Escames, G., Venegas, C., Ortiz, F., López, L. C., & Acuña-Castroviejo, D. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00647.x · Cited by 277 · see citing works

Aging, immunity and cancer

Hakim, F. T., Flomerfelt, F. A., Boyiadzis, M. M., & Gress, R. E. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.01.009 · Cited by 272 · see citing works

Melatonin rhythmicity: effect of age and Alzheimer's disease

Skene, D. J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00198-5 · Cited by 270 · see citing works

Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer’s type with disturbed sleep–waking

Mishima, K., Tozawa, T., Satoh, K., Matsumoto, Y., Hishikawa, Y., & Okawa, M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00510-6 · Cited by 269 · see citing works

Glossary of chronobiology

Franz Halberg, A., Carandente, F., Cornelissen-Guillaume, G. G., & Katinas, G. (1977) · Chronobiologia · Cited by 269 · see citing works

Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract

Huether, G., Pöeggeler, B., Reimer, A., & George, A. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90402-b · Cited by 267 · see citing works

Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia

Roth, T. G., Seiden, D., Sainati, S. M., Wang‐Weigand, S., Zhang, J., & Zee, P. C. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2006.01.003 · Cited by 265 · see citing works

Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites

Hardeland, R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8001-x · Cited by 253 · see citing works

Daily Melatonin Administration at Middle Age Suppresses Male Rate Visceral Fat, Plasma Leptin, and Plasma Insulin to Youthful Levels

Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., Yellon, S. M., & Matsumoto, A. M. (1999) · Endocrinology · doi:10.1210/endo.140.2.6674 · Cited by 250 · see citing works

Defining chronodisruption

Erren, T. C., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00665.x · Cited by 250 · see citing works

Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome

Potocki, L., Glaze, D., Tan, D.-X., Park, S.-S., Kashork, C. D., Shaffer, L. G., Reiter, R. J., & Lupski, J. R. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.6.428 · Cited by 244 · see citing works

Melatonin Administration to Blind People: Phase Advances and Entrainment

Sack, R. L., Lewy, A. J., Blood, M. L., Stevenson, J., & KEITH, L. D. (1991) · Journal of Biological Rhythms · doi:10.1177/074873049100600305 · Cited by 243 · see citing works

Suppression of Nocturnal Plasma Melatonin and 6-Sulphatoxymelatonin by Bright and Dim Light in Man

Bojkowski, C. J., Aldhous, M. E., English, J., Franey, C. S., Poulton, A. L., Skene, D. J., & Arendt, J. (1987) · Hormone and Metabolic Research · doi:10.1055/s-2007-1011846 · Cited by 233 · see citing works

Role of melatonin in neurodegenerative diseases

Srinivasan, V. J., Pandi-Perumal, S. R., Maestroni, G. J. M., Esquifino, A. I., Hardeland, R., & Cardinali, D. P. (2005) · Neurotoxicity Research · doi:10.1007/bf03033887 · Cited by 232 · see citing works

Melatonin mediates two distinct responses in vascular smooth muscle

Doolen, S., Krause, D. N., Dubocovich, M. L., & Duckles, S. P. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00064-8 · Cited by 229 · see citing works

Melatonin: Signaling mechanisms of a pleiotropic agent

Hardeland, R. (2009) · BioFactors · doi:10.1002/biof.23 · Cited by 227 · see citing works

Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors

Bourin, M., Mocaër, E., & Porsolt, R. D. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0414 · Cited by 226 · see citing works

Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease

Skene, D. J., VIVIEN‐ROELS, B., Sparks, D. L., Hunsaker, J. C., Pévet, P., Ravid, D., & Swaab, D. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)90214-v · Cited by 224 · see citing works

The role of circadian clock genes in mental disorders

Lamont, E. W., Coutu, D. L., Cermakian, N., & Boivin, D. B. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.3/elamont · Cited by 224 · see citing works

Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies

Wilhelmsen, M., Amirian, I., Reiter, R. J., Rosenberg, J., & Gögenür, I. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00895.x · Cited by 214 · see citing works

Disruption of retinoid‐related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice

André, É., Conquet, F., Steinmayr, M., Stratton, S. C., Porciatti, V., & Becker-André, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.3867 · Cited by 214 · see citing works

Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease

Wu, Y., Zhou, J., van Heerikhuize, J. J., Jockers, R., & Swaab, D. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.002 · Cited by 209 · see citing works

Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease

Savaskan, E., Ayoub, M. A., Ravid, R., Angeloni, D., FRASCHINI, F., Meier, F., Eckert, A., Müller-Spahn, F., & Jockers, R. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00169.x · Cited by 207 · see citing works

Increased brain damage after stroke or excitotoxic seizures in melatonin‐deficient rats

Manev, H., Uz, T., Kharlamov, A., & Joo, J. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.13.8940301 · Cited by 204 · see citing works

Clinical Aspects of Melatonin Intervention in Alzheimers Disease Progression

Cardinali, D. P., Furio, A. M., & Brusco, L. I. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246209 · Cited by 204 · see citing works

The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders

Jan, J. E., Reiter, R. J., Wasdell, M. B., & BAX, M. C. O. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00628.x · Cited by 203 · see citing works

Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events.

Blask, D. E., Sauer, L. A., Dauchy, R. T., Holowachuk, E. W., Ruhoff, M. S., & Kopff, H. S. (1999) · PubMed · Cited by 198 · see citing works

Stress, Aging, and Brain Oxidative Damage

Liu, J., & Mori, A. (1999) · Neurochemical Research · doi:10.1023/a:1022597010078 · Cited by 186 · see citing works

Human circadian rhythms: a multioscillatory system.

Aschoff, J., & Wever, R. (1976) · PubMed · Cited by 182 · see citing works

Melatonin: A Clock‐Output, A Clock‐Input

Stehle, J. H., von Gall, C., & Korf, H. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01001.x · Cited by 181 · see citing works

A three pulse phase response curve to three milligrams of melatonin in humans

Burgess, H. J., Revell, V. L., & Eastman, C. I. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143180 · Cited by 176 · see citing works

Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the “master clock”

Wu, Y., Fischer, D. F., Kalsbeek, A., Garidou, M., van der Vliet, J., Heijningen, C. L. V., Liu, R., Zhou, J., & Swaab, D. F. (2006) · The FASEB Journal · doi:10.1096/fj.05-4446fje · Cited by 175 · see citing works

Melatonin Secretion and Increased Daytime Sleepiness in Childhood Craniopharyngioma Patients

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Augmentation of indices of oxidative damage in life-long melatonin-deficient rats

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