The DOI matches its Crossref record; 790 of the 790 references it cites were found in a registry or an index.
Evidence for prescribing exercise as therapy in chronic disease
Open accessAbstract
Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including diseases that do not primarily manifest as disorders of the locomotive apparatus. In this review we present the evidence for prescribing exercise therapy in the treatment of metabolic syndrome‐related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases (chronic obstructive pulmonary disease, coronary heart disease, chronic heart failure, intermittent claudication), muscle, bone and joint diseases (osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome) and cancer, depression, asthma and type 1 diabetes. For each disease, we review the effect of exercise therapy on disease pathogenesis, on symptoms specific to the diagnosis, on physical fitness or strength and on quality of life. The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications.
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“Pedersen and Saltin [16] concluded that exercise can have a positive impact on symptoms and physical health via investigation of multiple meta-analyses about exercise and lipid profiles.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [16]
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“Regular physical activity offers protection against, and may be useful as a treatment for a wide variety of, chronic diseases associated with low-grade inflammation [12].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [12]
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Cited by
Sorted by citations
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514
Self-citationGleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Self-citationEkkekakis, P., Parfitt, G., & Petruzzello, S. J. (2011) · Sports Medicine · doi:10.2165/11590680-000000000-00000 · Cited by 1,215
Mann, S., Beedie, C., & Jimenez, A. (2014) · Sports Medicine · doi:10.1007/s40279-013-0110-5 · Cited by 801
Metadata
- Authors
- Pedersen, B. K., & Saltin, B.
- Affiliations
- University of Copenhagen (DK)
- ORCID
- Pedersen, B. K.
- Venue
- Scandinavian Journal of Medicine & Science in Sports
- Publisher
- Wiley
- Published
- 2006-02
- Volume
- 16
- Issue
- S1
- Pages
- 3-63
- ISSN
- 0905-7188 (ISSN-L)
- 1600-0838
- OpenAlex
- W2133576538
- Cited by
- 1,384
- References
- 790
- Citations by year
- 2026: 21 · 2025: 45 · 2024: 34 · 2023: 48 · 2022: 55 · 2021: 60 · 2020: 71 · 2019: 66 · 2018: 71 · 2017: 73 · 2016: 93 · 2015: 92 · 2014: 96 · 2013: 109 · 2012: 87
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- Danmarks Grundforskningsfond (# 02-512-55)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- exercise therapy, exercise prescription, chronic disease, physical activity, metabolic syndrome, insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity, chronic obstructive pulmonary disease, coronary artery disease, chronic heart failure, intermittent claudication, osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome, cancer, depression, asthma, type 1 diabetes, mechanism of action, quality of life, physical fitness, exercise contraindications
- MeSH terms
- Asthma, Cardiovascular Diseases, Depression, Humans, Metabolic Diseases, Motivation, Musculoskeletal Diseases, Neoplasms, Physical Fitness, Exercise, Exercise Tolerance, Pulmonary Disease, Chronic Obstructive
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