Cited by 112Caveolin-1 and cellular processesCellular transport and secretionExtracellular vesicles in disease

Caveolae: Stable Membrane Domains with a Potential for Internalization

Hommelgaard, Anette M., Roepstorff, Kirstine, Vilhardt, Frederik, Torgersen, Maria L., Sandvig, Kirsten, van Deurs, Bo·2005·Traffic

Abstract

The role of caveolae in endocytosis is hotly debated. Here, we argue that most caveolae are stable microdomains at the cell surface. Only a small fraction of caveolae is constitutively internalized, leading to a quantitatively minor uptake of ligands and receptors. In addition, we suggest that a more pronounced downregulation of caveolae from the plasma membrane can occur, presumably stimulated by receptor cross‐linking and clustering in caveolae. Finally, we propose that future studies dealing with internalization of caveolae should actually document such internalization and include kinetic data.

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Crossref · 10.1111/j.1600-0854.2005.00314.x

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40 of 40 references verified0 citation errors · 0 not checkable

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  • Cargos such as folic acid, cholera toxin B, albumin, glycosphingolipid analogs, and viruses such as SV40 and EV1 are internalized and endocytosed via caveolae.

    “The cargos such as folic acid, cholera toxin B, albumin, glycosphingolipid analogs, and viruses such as SV40 and EV1, are internalized and endocytosed via caveolae [99].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [99]

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Authors
Hommelgaard, A. M., Roepstorff, K., Vilhardt, F., Torgersen, M. L., Sandvig, K., & van Deurs, B.
Affiliations
  • University of Copenhagen (DK)
  • University of Oslo (NO)
Venue
Traffic
Publisher
Wiley
Published
2005-06-22
Volume
6
Issue
9
Pages
720-724
ISSN
  • 1398-9219 (ISSN-L)
  • 1600-0854
OpenAlex
W1607993735
Cited by
112
References
40
Citations by year
2025: 2 · 2024: 1 · 2023: 4 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
FWCI
0.99
Type
journal article
Language
en
Open access
closed
Locations
  • Traffic (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
Novo Nordisk Fonden
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
caveolae, endocytosis, plasma membrane microdomains, receptor down-regulation, receptor clustering, ligand uptake
MeSH terms
Endocytosis, Models, Biological, Down-Regulation, Caveolae, Membrane Microdomains, Caveolins

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