The intestinal barrier and its regulation by neuroimmune factors: Intestinal barrier and neuroimmune regulation

Keita, å. v.; Söderholm, J. D.

doi:10.1111/j.1365-2982.2010.01498.x

Cited by 286Gastrointestinal motility and disordersBarrier Structure and Function StudiesInflammatory Bowel Disease

The intestinal barrier and its regulation by neuroimmune factors: Intestinal barrier and neuroimmune regulation

Keita, å. v., Söderholm, J. D.·2010·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2010.01498.x

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Abstract

BACKGROUND: The ability to control uptake across the mucosa and protect from damage of harmful substances from the lumen is defined as intestinal barrier function. A disturbed barrier dysfunction has been described in many human diseases and animal models, for example, inflammatory bowel disease, irritable bowel syndrome, and intestinal hypersensitivity. In most diseases and models, alterations are seen both of the paracellular pathway, via the tight junctions, and of the transcellular routes, via different types of endocytosis. Recent studies of pathogenic mechanisms have demonstrated the important role of neuroimmune interaction with the epithelial cells in the regulation of barrier function. Neural impulses from extrinsic vagal and/or sympathetic efferent fibers or intrinsic enteric nerves influence mucosal barrier function via direct effects on epithelial cells or via interaction with immune cells. For example, by nerve-mediated activation by corticotropin-releasing hormone or cholinergic pathways, mucosal mast cells release a range of mediators with effects on transcellular, and/or paracellular permeability (for example, tryptase, TNF-alpha, nerve growth factor, and interleukins). PURPOSE: In this review, we discuss current physiological and pathophysiological aspects of the intestinal barrier and, in particular, its regulation by neuroimmune factors.

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Vagal afferents can respond to histamine, suggesting a route by which microbial-derived histamine may interact with the host nervous system.
“Interestingly vagal afferents can respond to histamine (Keita and Soderholm, 2010), suggesting a route by which microbial-derived histamine may interact with the host nervous system.”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Keita and Soderholm, 2010
In animal models, altered autonomic nervous system activity such as anxiety and stress may play a key role in the pathogenesis of increased intestinal permeability found in the ASD population.
“A further confirmation of the possible central regulation mechanism of the gut-brain axis comes from studies on animal models, where it has been observed that an alteration of autonomic nervous system activity, such as anxiety and stress, could play a key role in the pathogenesis of increased permeability of the intestinal epithelium, found in the ASD population [40,157,158].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [157]

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Authors: Keita, Å. V., & Söderholm, J. D.
Affiliations: Linköping University (SE)
Corresponding author: Söderholm, J. D.
ORCID: Keita, å. v.
Söderholm, J. D.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2010-02-08
Volume: 22
Issue: 7
Pages: 718-733
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2010.01498.x
OpenAlex: W1564282281
Cited by: 286
References: 175
Citations by year: 2026: 7 · 2025: 17 · 2024: 15 · 2023: 15 · 2022: 18 · 2021: 31 · 2020: 18 · 2019: 22 · 2018: 20 · 2017: 15 · 2016: 19 · 2015: 13 · 2014: 18 · 2013: 20 · 2012: 14
FWCI: 2.84
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2031 d)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords: intestinal barrier function, neuroimmune interactions, tight junctions, paracellular permeability, transcellular permeability, endocytosis, enteric nervous system, vagal innervation, sympathetic innervation, mast cells, corticotropin-releasing factor, cholinergic pathways, inflammatory bowel disease, irritable bowel syndrome, intestinal hypersensitivity, epithelial cells
MeSH terms: Animals, Disease Models, Animal, Epithelium, Humans, Intestinal Diseases, Intestinal Mucosa, Intestines, Inflammatory Bowel Diseases, Neuroimmunomodulation, Enteric Nervous System, Neurotransmitter Agents

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The intestinal barrier and its regulation by neuroimmune factors: Intestinal barrier and neuroimmune regulation

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