The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Caveolae: Stable Membrane Domains with a Potential for Internalization
Abstract
The role of caveolae in endocytosis is hotly debated. Here, we argue that most caveolae are stable microdomains at the cell surface. Only a small fraction of caveolae is constitutively internalized, leading to a quantitatively minor uptake of ligands and receptors. In addition, we suggest that a more pronounced downregulation of caveolae from the plasma membrane can occur, presumably stimulated by receptor cross‐linking and clustering in caveolae. Finally, we propose that future studies dealing with internalization of caveolae should actually document such internalization and include kinetic data.
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“The cargos such as folic acid, cholera toxin B, albumin, glycosphingolipid analogs, and viruses such as SV40 and EV1, are internalized and endocytosed via caveolae [99].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [99]
Citations
Cites
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Self-citationRegulated internalization of caveolae.
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Self-citationMicrovascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice
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Association with Membrane Protrusions Makes ErbB2 an Internalization-resistant Receptor
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Self-citationUpla, P., Marjomäki, V., Kankaanpää, P., Ivaska, J., Hyypiä, T., van der Goot, F. G., & Heino, J. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-08-0588 · Cited by 168
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Caveolin-1 Interacts Directly with Dynamin-2
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Self-citationCholera Toxin Toxicity Does Not Require Functional Arf6- and Dynamin-dependent Endocytic Pathways
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Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor
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Self-citationCholera Toxin Entry into Pig Enterocytes Occurs via a Lipid Raft- and Clathrin-Dependent Mechanism
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Metadata
- Authors
- Hommelgaard, A. M., Roepstorff, K., Vilhardt, F., Torgersen, M. L., Sandvig, K., & van Deurs, B.
- Affiliations
- University of Copenhagen (DK)
- University of Oslo (NO)
- Corresponding author
- van Deurs, Bo
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2005-06-22
- Volume
- 6
- Issue
- 9
- Pages
- 720-724
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1607993735
- Cited by
- 112
- References
- 40
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Traffic (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Novo Nordisk Fonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- caveolae, endocytosis, plasma membrane microdomains, receptor down-regulation, receptor clustering, ligand uptake
- MeSH terms
- Endocytosis, Models, Biological, Down-Regulation, Caveolae, Membrane Microdomains, Caveolins
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