Cited by 112Caveolin-1 and cellular processesCellular transport and secretionExtracellular vesicles in disease

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Caveolae: Stable Membrane Domains with a Potential for Internalization

Hommelgaard, Anette M., Roepstorff, Kirstine, Vilhardt, Frederik, Torgersen, Maria L., Sandvig, Kirsten, van Deurs, Bo·2005·Traffic

DOI 10.1111/j.1600-0854.2005.00314.x

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Abstract

The role of caveolae in endocytosis is hotly debated. Here, we argue that most caveolae are stable microdomains at the cell surface. Only a small fraction of caveolae is constitutively internalized, leading to a quantitatively minor uptake of ligands and receptors. In addition, we suggest that a more pronounced downregulation of caveolae from the plasma membrane can occur, presumably stimulated by receptor cross‐linking and clustering in caveolae. Finally, we propose that future studies dealing with internalization of caveolae should actually document such internalization and include kinetic data.

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Authors: Hommelgaard, A. M., Roepstorff, K., Vilhardt, F., Torgersen, M. L., Sandvig, K., & van Deurs, B.
Affiliations: University of Copenhagen (DK)
University of Oslo (NO)
Corresponding author: van Deurs, Bo
ORCID: Vilhardt, Frederik
Torgersen, Maria L.
Sandvig, Kirsten
Venue: Traffic
Publisher: Wiley
Published: 2005-06-22
Volume: 6
Issue: 9
Pages: 720-724
ISSN: 1398-9219 (ISSN-L)
1600-0854
DOI: 10.1111/j.1600-0854.2005.00314.x
OpenAlex: W1607993735
Cited by: 112
References: 40
Citations by year: 2025: 2 · 2024: 1 · 2023: 4 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
FWCI: 0.99
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Traffic (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Novo Nordisk Fonden
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: caveolae, endocytosis, plasma membrane microdomains, receptor down-regulation, receptor clustering, ligand uptake
MeSH terms: Endocytosis, Models, Biological, Down-Regulation, Caveolae, Membrane Microdomains, Caveolins

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Caveolae: Stable Membrane Domains with a Potential for Internalization

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