The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Caveolae: Stable Membrane Domains with a Potential for Internalization
Abstract
The role of caveolae in endocytosis is hotly debated. Here, we argue that most caveolae are stable microdomains at the cell surface. Only a small fraction of caveolae is constitutively internalized, leading to a quantitatively minor uptake of ligands and receptors. In addition, we suggest that a more pronounced downregulation of caveolae from the plasma membrane can occur, presumably stimulated by receptor cross‐linking and clustering in caveolae. Finally, we propose that future studies dealing with internalization of caveolae should actually document such internalization and include kinetic data.
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“The cargos such as folic acid, cholera toxin B, albumin, glycosphingolipid analogs, and viruses such as SV40 and EV1, are internalized and endocytosed via caveolae [99].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [99]
Citations
Cites
Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
Pelkmans, L., Kartenbeck, J., & Helenius, A. (2001) · Nature Cell Biology · doi:10.1038/35074539 · Cited by 1,236
Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
Guglielmo, G. M. D., Roy, C. L., Goodfellow, A. F., & Wrana, J. L. (2003) · Nature Cell Biology · doi:10.1038/ncb975 · Cited by 1,152
Rodal, S. K., Skretting, G., Garred, Ø., Vilhardt, F., van Deurs, B., & Sandvig, K. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.961 · Cited by 1,009
Self-citationRegulated internalization of caveolae.
Parton, R. G., Joggerst, B., & Simons, K. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.5.1199 · Cited by 755
Caveolae/raft-dependent endocytosis
Nabi, I. R., & Le, P. U. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302028 · Cited by 750
Pelkmans, L., & Helenius, A. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30501.x · Cited by 746
Clathrin-independent endocytosis of ubiquitinated cargos
Sigismund, S., Woelk, T., Puri, C., Maspero, E., Tacchetti, C., Transidico, P., Di Fiore, P. P., & Polo, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409817102 · Cited by 739
Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae
Pelkmans, L., Püntener, D., & Helenius, A. (2002) · Science · doi:10.1126/science.1069784 · Cited by 727
Sabharanjak, S., Sharma, P., Parton, R. G., & Mayor, S. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00145-4 · Cited by 647
Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms
Parton, R. G., & Richards, A. A. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00128.x · Cited by 603
Research works printed but not linked: 1
- 10.1021/bi047959 · DOI
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Iversen, T., Skotland, T., & Sandvig, K. (2011) · Nano Today · doi:10.1016/j.nantod.2011.02.003 · Cited by 1,267
Self-citationPathogen recognition and development of particulate vaccines: Does size matter?
Xiang, S. D., Scholzen, A., Minigo, G., David, C. T., Apostolopoulos, V., Mottram, P. L., & Plebanski, M. (2006) · Methods · doi:10.1016/j.ymeth.2006.05.016 · Cited by 602
The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability
Schoultz, I., & Keita, Å. V. (2020) · Cells · doi:10.3390/cells9081909 · Cited by 517
Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 446
Lipid Rafts, Caveolae, and Their Endocytosis
Lajoie, P., & Nabi, I. R. (2010) · International review of cytology · doi:10.1016/s1937-6448(10)82003-9 · Cited by 370
Metadata
- Authors
- Hommelgaard, A. M., Roepstorff, K., Vilhardt, F., Torgersen, M. L., Sandvig, K., & van Deurs, B.
- Affiliations
- University of Copenhagen (DK)
- University of Oslo (NO)
- Corresponding author
- van Deurs, Bo
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2005-06-22
- Volume
- 6
- Issue
- 9
- Pages
- 720-724
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1607993735
- Cited by
- 112
- References
- 40
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Traffic (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Novo Nordisk Fonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- caveolae, endocytosis, plasma membrane microdomains, receptor down-regulation, receptor clustering, ligand uptake
- MeSH terms
- Endocytosis, Models, Biological, Down-Regulation, Caveolae, Membrane Microdomains, Caveolins
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