The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cholesterol‐Induced Caveolin Targeting to Lipid Droplets in Adipocytes: A Role for Caveolar Endocytosis
Open accessAbstract
We have investigated the targeting of caveolin to lipid bodies in adipocytes that express high levels of caveolins and contain well‐developed lipid droplets. We observed that the lipid droplets isolated from adipocytes of caveolin‐1 knock out mice contained dramatically reduced levels of cholesterol, indicating that caveolin is required for maintaining the cholesterol content of this organelle. Analysis of caveolin distribution by cell fractionation and fluorescent light microscopy in 3T3‐L1 adipocytes indicated that addition of cholesterol rapidly stimulated translocation of caveolin to lipid droplets. The cholesterol‐induced trafficking of caveolins to lipid droplets was shown to be dynamin‐ and protein kinase C (PKC)‐dependent and modulated by src tyrosine kinase activation, suggesting a role for caveolar endocytosis in this novel trafficking pathway. Consistent with this, caveolae budding was stimulated by cholesterol addition. The present data identify lipid droplets as potential target organelles for caveolar endocytosis and demonstrate a role for caveolin‐1 in the maintenance of free cholesterol levels in adipocyte lipid droplets.
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Citations
Cites
Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles
Kirkham, M., Fujita, A., Chadda, R., Nixon, S. J., Kurzchalia, T. V., Sharma, D. K., Pagano, R. E., Hancock, J. F., Mayor, S., & Parton, R. G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407078 · Cited by 439
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The multiple faces of caveolae
Parton, R. G., & Simons, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2122 · Cited by 1,454
Self-citationThe biophysics and cell biology of lipid droplets
Thiam, A. R., Farese Jr, R. V., & Walther, T. C. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3699 · Cited by 986
Not Just Fat: The Structure and Function of the Lipid Droplet
Fujimoto, T., & Parton, R. G. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004838 · Cited by 484
Self-citationCD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis
Hao, J.-W., Wang, J., Guo, H., Zhao, Y.-Y., Sun, H.-H., Li, Y.-F., Lai, X.-Y., Zhao, N., Wang, X., Xie, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18565-8 · Cited by 423
Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan
Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338
Metadata
- Authors
- Le Lay, S., Hajduch, E., Lindsay, M. R., Le Lièpvre, X., Thiele, C., Ferré, P., Parton, R. G., Kurzchalia, T., Simons, K., & Dugail, I.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2006-03-16
- Volume
- 7
- Issue
- 5
- Pages
- 549-561
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1685802105
- Cited by
- 182
- References
- 1
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Le Lay, S., Hajduch, E., Lindsay, M. R., Le Lièpvre, X., Thiele, C., Ferré, P., Parton, R. G., Kurzchalia, T., Simons, K., & Dugail, I. (2006). Cholesterol‐Induced Caveolin Targeting to Lipid Droplets in Adipocytes: A Role for Caveolar Endocytosis. Traffic. https://doi.org/10.1111/j.1600-0854.2006.00406.x
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