The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Exorcising the Exocyst Complex
Open accessAbstract
The exocyst complex is an evolutionarily conserved multisubunit protein complex implicated in tethering secretory vesicles to the plasma membrane. Originally identified two decades ago in budding yeast, investigations using several different eukaryotic systems have since made great progress toward determination of the overall structure and organization of the eight exocyst subunits. Studies point to a critical role for the complex as a spatiotemporal regulator through the numerous protein and lipid interactions of its subunits, although a molecular understanding of exocyst function has been challenging to elucidate. Recent progress demonstrates that the exocyst is also important for additional trafficking steps and cellular processes beyond exocytosis, with links to development and disease. In this review, we discuss current knowledge of exocyst architecture, assembly, regulation and its roles in a variety of cellular trafficking pathways.
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Citations
Cites
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · cited 2×
“The exocyst also has roles in host survival responses – several studies have linked exocyst function to various aspects of the innate immune response (92,93).”
BackgroundMolecular anatomy of a trafficking organelle
Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373
Rabs and their effectors: achieving specificity in membrane traffic
Grosshans, B. L., Ortiz, D., & Novick, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601617103 · Cited by 1,005
Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase
Jin, R., Junutula, J. R., Matern, H. T., Ervin, K. E., Scheller, R. H., & Brunger, A. T. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600699 · Cited by 145
Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex
Fukai, S., Matern, H. T., Jagath, J. R., Scheller, R. H., & Brunger, A. T. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg329 · Cited by 126
Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex
Lalli, G., & Hall, A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507061 · Cited by 112
Cited by
Lysosome-targeting chimaeras for degradation of extracellular proteins
Banik, S. M., Pedram, K., Wisnovsky, S., Ahn, G., Riley, N. M., & Bertozzi, C. R. (2020) · Nature · doi:10.1038/s41586-020-2545-9 · Cited by 1,199
Cellular and molecular mechanisms of MT1-MMP-dependent cancer cell invasion.
Castro-Castro, A., Marchesin, V., Monteiro, P., Lodillinsky, C., Rossé, C., & Chavrier, P. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125227 · Cited by 249
Cryo-EM structure of the exocyst complex
Mei, K., Li, Y., Wang, S., Shao, G., Wang, J., Ding, Y., Luo, G., Yue, P., Liu, J.-J., Wang, X., et al. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-017-0016-2 · Cited by 156
Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms
Moreiras, H., Seabra, M. C., & Barral, D. C. (2021) · doi:10.20944/preprints202104.0441.v1 · Cited by 147
PI(4,5)P2-binding effector proteins for vesicle exocytosis
Martin, T. F. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.017 · Cited by 124
Metadata
- Authors
- Heider, M. R., & Munson, M.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2012-04-08
- Volume
- 13
- Issue
- 7
- Pages
- 898-907
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1586396057
- Cited by
- 344
- References
- 6
- FWCI
- 16.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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