The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Suppression by Human Placental Protein 14 of Natural Killer Cell Activity
Abstract
Human decidua of early pregnancy contains considerable numbers of CD3-CD56+ natural killer (NK) cells. In this study, two major protein products of the decidua, placental protein 14 (PP14) and placental protein 12 (PP12), were tested for the ability to regulate human NK cell activity. In vitro overnight exposure to PP14 of blood lymphocytes or purified large granular lymphocytes (LGL) resulted in suppression of cytotoxicity against K562 target cells in a 4-h 51Cr release assay. The NK inhibition was dependent on concentrations of PP14, being detectable at 5 micrograms/ml and reaching maximum at 50 micrograms/ml. Manifestation of PP14-induced NK suppression required 18-h contact with NK cells. The suppression of NK activity by PP14 was not abolished by indomethacin. In a target binding assay the number of PP14-treated LGL binding to K562 was comparable to that of untreated ones. By contrast with PP14, PP12 produced no effects on NK cells. These results indicate that PP14 suppresses the function of NK cells, which might be involved in prevention of maternal immune rejection of fetus at the fetomaternal interface.
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“As an example, the high glycodelin concentrations in peritoneal fluid might protect early lesions from NK cell attack (261, 262) and could thus facilitate survival.”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [262]
In the citing paper
“Interestingly, glycodelins in concentrations as secreted by endometriosis cells in PF (107) decrease the natural killer activity (108), which can be viewed as an autoprotective mechanism of the endometriotic cell.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [108]
Citations
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Additional file 4 of Is neonatal uterine bleeding responsible for early-onset endometriosis?
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Metadata
- Authors
- OKAMOTO, N., UCHIDA, A., TAKAKURA, K., KARIYA, Y., KANZAKI, H., RIITTINEN, L., KOISTINEN, R., SEPPÄLÄ, M., & MORI, T.
- Affiliations
- Kyoto University (JP)
- Helsinki University Hospital (FI)
- Corresponding author
- OKAMOTO, NORIHIKO
- Venue
- American Journal of Reproductive Immunology
- Publisher
- Wiley
- Published
- 1991-12
- Volume
- 26
- Issue
- 4
- Pages
- 137-142
- ISSN
- 0271-7352 (ISSN-L)
- 1046-7408
- 1600-0897
- OpenAlex
- W2122340409
- Cited by
- 234
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 6 · 2012: 6
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- placental protein 14, natural killer cells, NK cell inhibition, decidua, large granular lymphocytes, cytotoxicity, K562 cells, fetomaternal interface, pregnancy immunology
- MeSH terms
- Glycodelin, Cells, Cultured, Cytotoxicity, Immunologic, Female, Glycoproteins, Humans, Immune Tolerance, Indomethacin, Killer Cells, Natural, Leukocytes, Mononuclear, Pregnancy, Pregnancy Proteins
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