Cited by 220Reproductive System and PregnancyPregnancy-related medical researchPregnancy and preeclampsia studies

Identification of placental protein 14 as an immunosuppressive factor in human reproduction

Bolton, A.E., Clough, K.J., Stoker, R.J., Pockley, A.G., Mowles, E.A., Westwood, O.M.R., Chapman, M.G.·1987·The Lancet

Abstract

Extracts of human decidual tissue obtained in the first trimester of pregnancy showed potent suppressive activity in mixed lymphocyte cultures. These extracts contained substantial amounts of the decidual protein PP14. Purified PP14 also exhibited in vitro immunosuppressive activity, and such activity in decidual extract and purified PP14 preparations was removed by treatment with a monoclonal anti-PP14 antibody-based immunoadsorbent. PP14 was present in seminal plasma, which also exhibited immunosuppressive activity that could be reduced, but not removed, by the immunoadsorbent. PP14 may be an important immunomodulator in the human reproductive system.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(87)90235-2

Cites

29 of 29 references verified0 citation errors · 0 not checkable

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  • High glycodelin concentrations in peritoneal fluid might protect early lesions from NK cell attack and could thus facilitate survival.

    “As an example, the high glycodelin concentrations in peritoneal fluid might protect early lesions from NK cell attack (261, 262) and could thus facilitate survival.”

    From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [261]

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Authors
Bolton, A. E., Clough, K. J., Stoker, R. J., Pockley, A. G., Mowles, E. A., Westwood, O. M. R., & Chapman, M. G.
Venue
The Lancet
Publisher
Elsevier BV
Published
1987-03
Volume
329
Issue
8533
Pages
593-595
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W1998710143
Cited by
220
References
30
Citations by year
2025: 1 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
FWCI
3.65
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
placental protein 14, immunosuppression, decidua, first trimester, mixed lymphocyte reaction, seminal plasma, immunoadsorbent, immunomodulation, human reproduction
MeSH terms
Glycodelin, Animals, Antibodies, Monoclonal, Endometrium, Female, Glycoproteins, Humans, Immunosorbents, Immunosuppression Therapy, Lymphocyte Culture Test, Mixed, Male, Mice, Inbred BALB C, Pregnancy, Pregnancy Proteins, Thymidine, Tritium, Mice

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