Identification of placental protein 14 as an immunosuppressive factor in human reproduction
Abstract
Extracts of human decidual tissue obtained in the first trimester of pregnancy showed potent suppressive activity in mixed lymphocyte cultures. These extracts contained substantial amounts of the decidual protein PP14. Purified PP14 also exhibited in vitro immunosuppressive activity, and such activity in decidual extract and purified PP14 preparations was removed by treatment with a monoclonal anti-PP14 antibody-based immunoadsorbent. PP14 was present in seminal plasma, which also exhibited immunosuppressive activity that could be reduced, but not removed, by the immunoadsorbent. PP14 may be an important immunomodulator in the human reproductive system.
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High glycodelin concentrations in peritoneal fluid might protect early lesions from NK cell attack and could thus facilitate survival.
“As an example, the high glycodelin concentrations in peritoneal fluid might protect early lesions from NK cell attack (261, 262) and could thus facilitate survival.”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [261]
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- Authors
- Bolton, A. E., Clough, K. J., Stoker, R. J., Pockley, A. G., Mowles, E. A., Westwood, O. M. R., & Chapman, M. G.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1987-03
- Volume
- 329
- Issue
- 8533
- Pages
- 593-595
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1998710143
- Cited by
- 220
- References
- 30
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- placental protein 14, immunosuppression, decidua, first trimester, mixed lymphocyte reaction, seminal plasma, immunoadsorbent, immunomodulation, human reproduction
- MeSH terms
- Glycodelin, Animals, Antibodies, Monoclonal, Endometrium, Female, Glycoproteins, Humans, Immunosorbents, Immunosuppression Therapy, Lymphocyte Culture Test, Mixed, Male, Mice, Inbred BALB C, Pregnancy, Pregnancy Proteins, Thymidine, Tritium, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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