Cited by 234Reproductive System and PregnancyImmune Cell Function and InteractionPregnancy and preeclampsia studies

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Suppression by Human Placental Protein 14 of Natural Killer Cell Activity

OKAMOTO, NORIHIKO, UCHIDA, ATSUSHI, TAKAKURA, KENJI, KARIYA, YOSHITAKA, KANZAKI, HIDEHARU, RIITTINEN, LEENA, KOISTINEN, RIITTA, SEPPÄLÄ, MARKKU, MORI, TAKAHIDE·1991·American Journal of Reproductive Immunology

DOI 10.1111/j.1600-0897.1991.tb00713.x

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Abstract

Human decidua of early pregnancy contains considerable numbers of CD3-CD56+ natural killer (NK) cells. In this study, two major protein products of the decidua, placental protein 14 (PP14) and placental protein 12 (PP12), were tested for the ability to regulate human NK cell activity. In vitro overnight exposure to PP14 of blood lymphocytes or purified large granular lymphocytes (LGL) resulted in suppression of cytotoxicity against K562 target cells in a 4-h 51Cr release assay. The NK inhibition was dependent on concentrations of PP14, being detectable at 5 micrograms/ml and reaching maximum at 50 micrograms/ml. Manifestation of PP14-induced NK suppression required 18-h contact with NK cells. The suppression of NK activity by PP14 was not abolished by indomethacin. In a target binding assay the number of PP14-treated LGL binding to K562 was comparable to that of untreated ones. By contrast with PP14, PP12 produced no effects on NK cells. These results indicate that PP14 suppresses the function of NK cells, which might be involved in prevention of maternal immune rejection of fetus at the fetomaternal interface.

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Authors: OKAMOTO, N., UCHIDA, A., TAKAKURA, K., KARIYA, Y., KANZAKI, H., RIITTINEN, L., KOISTINEN, R., SEPPÄLÄ, M., & MORI, T.
Affiliations: Kyoto University (JP)
Helsinki University Hospital (FI)
Corresponding author: OKAMOTO, NORIHIKO
Venue: American Journal of Reproductive Immunology
Publisher: Wiley
Published: 1991-12
Volume: 26
Issue: 4
Pages: 137-142
ISSN: 0271-7352 (ISSN-L)
1046-7408
1600-0897
DOI: 10.1111/j.1600-0897.1991.tb00713.x
OpenAlex: W2122340409
Cited by: 234
References: 25
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 6 · 2012: 6
FWCI: 2.79
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7830 d)
Locations: American Journal of Reproductive Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: placental protein 14, natural killer cells, NK cell inhibition, decidua, large granular lymphocytes, cytotoxicity, K562 cells, fetomaternal interface, pregnancy immunology
MeSH terms: Glycodelin, Cells, Cultured, Cytotoxicity, Immunologic, Female, Glycoproteins, Humans, Immune Tolerance, Indomethacin, Killer Cells, Natural, Leukocytes, Mononuclear, Pregnancy, Pregnancy Proteins

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Suppression by Human Placental Protein 14 of Natural Killer Cell Activity

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