Cited by 1,431Reproductive System and PregnancyCOVID-19 Impact on ReproductionPreterm Birth and Chorioamnionitis

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REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity

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Mor, Gil, Cardenas, Ingrid·2010·American Journal of Reproductive Immunology

DOI 10.1111/j.1600-0897.2010.00836.xPMC PMC3025805

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Citation Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 2010 Placental immune response and its tropism for specific viruses and pathogens affect the outcome of the pregnant woman’s susceptibility to and severity of certain infectious diseases. The generalization of pregnancy as a condition of immune suppression or increased risk is misleading and prevents the determination of adequate guidelines for treating pregnant women during pandemics. There is a need to evaluate the interaction of each specific pathogen with the fetal/placental unit and its responses to design the adequate prophylaxis or therapy. The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions. Our challenge as scientists and clinicians interested in the field of reproductive immunology is to evaluate many of the ‘classical concepts’ to define new approaches for a better understanding of the immunology of pregnancy that will benefit mothers and fetuses in different clinical scenarios.

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Authors: Mor, G., & Cardenas, I.
Affiliations: Yale University (US)
Corresponding author: Mor, Gil
ORCID: Mor, Gil
Cardenas, Ingrid
Venue: American Journal of Reproductive Immunology
Publisher: Wiley
Published: 2010-05-10
Volume: 63
Issue: 6
Pages: 425-433
ISSN: 0271-7352 (ISSN-L)
1046-7408
1600-0897
DOI: 10.1111/j.1600-0897.2010.00836.x
PMC: PMC3025805
OpenAlex: W49611453
Cited by: 1,431
References: 55
Citations by year: 2026: 143 · 2025: 94 · 2024: 133 · 2023: 123 · 2022: 136 · 2021: 140 · 2020: 154 · 2019: 79 · 2018: 87 · 2017: 71 · 2016: 61 · 2015: 55 · 2014: 54 · 2013: 43 · 2012: 30
FWCI: 2.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: American Journal of Reproductive Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01 HD023342, P01HD054713)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
Keywords: pregnancy immunology, placental immunity, reproductive immunology
MeSH terms: Female, Humans, Immune System, Placenta, Pregnancy, Pregnancy Complications, Infectious, Virus Diseases

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