The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity
Open accessAbstract
Citation Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 2010 Placental immune response and its tropism for specific viruses and pathogens affect the outcome of the pregnant woman’s susceptibility to and severity of certain infectious diseases. The generalization of pregnancy as a condition of immune suppression or increased risk is misleading and prevents the determination of adequate guidelines for treating pregnant women during pandemics. There is a need to evaluate the interaction of each specific pathogen with the fetal/placental unit and its responses to design the adequate prophylaxis or therapy. The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions. Our challenge as scientists and clinicians interested in the field of reproductive immunology is to evaluate many of the ‘classical concepts’ to define new approaches for a better understanding of the immunology of pregnancy that will benefit mothers and fetuses in different clinical scenarios.
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“There is evidence that the mother changes the balance of her T-cell responses to Th2 rather than Th1 [68].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [68]
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Sorted by citations
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165
Evolution of the immune system in humans from infancy to old age
Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796
Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096
Inflammation and pregnancy: the role of the immune system at the implantation site
Mor, G., Cardenas, I., Abrahams, V. M., & Guller, S. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05938.x · Cited by 1,111
Self-citationThe unique immunological and microbial aspects of pregnancy
Mor, G., Aldo, P., & Alvero, A. B. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.64 · Cited by 1,041
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Metadata
- Authors
- Mor, G., & Cardenas, I.
- Affiliations
- Yale University (US)
- Corresponding author
- Mor, Gil
- Venue
- American Journal of Reproductive Immunology
- Publisher
- Wiley
- Published
- 2010-05-10
- Volume
- 63
- Issue
- 6
- Pages
- 425-433
- ISSN
- 0271-7352 (ISSN-L)
- 1046-7408
- 1600-0897
- PMC
- PMC3025805
- OpenAlex
- W49611453
- Cited by
- 1,431
- References
- 55
- Citations by year
- 2026: 143 · 2025: 94 · 2024: 133 · 2023: 123 · 2022: 136 · 2021: 140 · 2020: 154 · 2019: 79 · 2018: 87 · 2017: 71 · 2016: 61 · 2015: 55 · 2014: 54 · 2013: 43 · 2012: 30
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01 HD023342, P01HD054713)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Keywords
- pregnancy immunology, placental immunity, reproductive immunology
- MeSH terms
- Female, Humans, Immune System, Placenta, Pregnancy, Pregnancy Complications, Infectious, Virus Diseases
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