The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The Survival Benefit of Liver Transplantation
Open accessAbstract
Demand for liver transplantation continues to exceed donor organ supply. Comparing recipient survival to that of comparable candidates without a transplant can improve understanding of transplant survival benefit. Waiting list and post-transplant mortality was studied among a cohort of 12 996 adult patients placed on the waiting list between 2001 and 2003. Time-dependent Cox regression models were fitted to determine relative mortality rates for candidates and recipients. Overall, deceased donor transplant recipients had a 79% lower mortality risk than candidates (HR = 0.21; p < 0.001). At Model for End-stage Liver Disease (MELD) 18-20, mortality risk was 38% lower (p < 0.01) among recipients compared to candidates. Survival benefit increased with increasing MELD score; at the maximum score of 40, recipient mortality risk was 96% lower than that for candidates (p < 0.001). In contrast, at lower MELD scores, recipient mortality risk during the first post-transplant year was much higher than for candidates (HR = 3.64 at MELD 6-11, HR = 2.35 at MELD 12-14; both p < 0.001). Liver transplant survival benefit at 1 year is concentrated among patients at higher risk of pre-transplant death. Futile transplants among severely ill patients are not identified under current practice. With 1 year post-transplant follow-up, patients at lower risk of pre-transplant death do not have a demonstrable survival benefit from liver transplant.
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Wolfe, R. A., Ashby, V. B., Milford, E. L., Ojo, A. O., Ettenger, R. E., Agodoa, L. Y. C., Held, P. J., & Port, F. K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912023412303 · Cited by 5,371
Self-citationA Model to Predict Survival in Patients With End–Stage Liver Disease
Kamath, P. S., Wiesner, R. H., Malinchoc, M., Kremers, W., Therneau, T. M., Kosberg, C. L., D'Amico, G., Dickson, R. E., & Kim, R. W. (2001) · Hepatology · doi:10.1053/jhep.2001.22172 · Cited by 4,975
Malinchoc, M., Kamath, P. S., Gordon, F. D., Peine, C. J., Rank, J., & ter Borg, P. C. J. (2000) · Hepatology · doi:10.1053/he.2000.5852 · Cited by 2,893
Model for end-stage liver disease (MELD) and allocation of donor livers
Wiesner, R., Edwards, E., Freeman, R., Harper, A., Kim, R., Kamath, P., Kremers, W., Lake, J., Howard, T., Merion, R. M., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50016 · Cited by 2,528
Self-citationMELD and PELD: Application of survival models to liver allocation
Wiesner, R. H., McDiarmid, S. V., Kamath, P. S., Edwards, E. B., Malinchoc, M., Kremers, W. K., Krom, R. A. F., & Kim, R. W. (2001) · Liver Transplantation · doi:10.1053/jlts.2001.25879 · Cited by 864
Results of the first year of the new liver allocation plan
Freeman, R. B., Wiesner, R. H., Edwards, E., Harper, A., Merion, R., & Wolfe, R. (2004) · Liver Transplantation · doi:10.1002/lt.20024 · Cited by 434
Self-citationMcDiarmid, S. V., Anand, R., & Lindblad, A. S. (2002) · Transplantation · doi:10.1097/00007890-200207270-00006 · Cited by 395
Longitudinal assessment of mortality risk among candidates for liver transplantation
Merion, R. M., Wolfe, R. A., Dykstra, D. M., Leichtman, A. B., Gillespie, B., & Held, P. J. (2003) · Liver Transplantation · doi:10.1053/jlts.2003.50009 · Cited by 216
Self-citationOnaca, N. N., Levy, M. F., Sanchez, E. Q., Chinnakotla, S., Fasola, C. G., Thomas, M. J., Weinstein, J. S., Murray, N. G., Goldstein, R. M., & Klintmalm, G. B. (2003) · Liver Transplantation · doi:10.1053/jlts.2003.50027 · Cited by 202
MELD score predicts 1-year patient survival post-orthotopic liver transplantation
Saab, S., Wang, V., Ibrahim, A. B., Durazo, F., Han, S., Farmer, D. G., Yersiz, H., Morrisey, M., Goldstein, L. I., Ghobrial, M. R., et al. (2003) · Liver Transplantation · doi:10.1053/jlts.2003.50090 · Cited by 195
Cited by
The model for end-stage liver disease (MELD)
Kamath, P. S., & Kim, R. W. (2007) · Hepatology · doi:10.1002/hep.21563 · Cited by 1,674
Ginès, P., Krag, A., Abraldes, J. G., Solà, E., Fabrellas, N., & Kamath, P. S. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01374-x · Cited by 1,663
EASL Clinical Practice Guidelines: Liver transplantation
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.006 · Cited by 1,082
Martin, P., DiMartini, A., Feng, S., Brown, R., & Fallon, M. (2014) · Hepatology · doi:10.1002/hep.26972 · Cited by 1,045
EASL Clinical Practical Guidelines: Management of Alcoholic Liver Disease
European Association for the Study of the Liver (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.004 · Cited by 720
Metadata
- Authors
- Merion, R. M., Schaubel, D. E., Dykstra, D. M., Freeman, R. B., Port, F. K., & Wolfe, R. A.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 5
- Issue
- 2
- Pages
- 307-313
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2013502482
- Cited by
- 872
- References
- 14
- FWCI
- 46.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
