The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Significance of Donor-Specific HLA Antibodies in Rejection and Ductopenia Development in ABO Compatible Liver Transplantation
Open accessAbstract
The role of humoral alloreactivity in ABO-compatible liver transplantation remains unclear. To understand the significance of donor-specific HLA alloantibodies (DSA) in liver rejection, we applied the currently used strategy for detection of antibody-mediated rejection of other solid allografts. For this purpose we reviewed the data on 43 recipients of ABO identical/compatible donor livers who had indication liver biopsy stained for complement element C4d and contemporaneous circulating DSA determination. Seventeen (40%) patients had significant circulating DSA in association with diffuse portal C4d deposition (DSA+/diffuse C4d+). These DSA+/diffuse C4d+ subjects had higher frequency of acute cellular rejection (ACR) 15/17 versus 13/26 (88% vs. 50%), p = 0.02, and steroid resistant rejection 7/17 versus 5/26 (41% vs. 19%), p = 0.03. Based on detection of the combination DSA+/diffuse C4d+, 53.6% of cases of ACR had evidence of concurrent humoral alloreactivity. Six of the 10 patients with ductopenic rejection had circulating DSA and diffuse portal C4d, three of whom (2 early and 1 late posttransplantation) developed unrelenting cholestasis, necessitating specific antibody-depleting therapy to salvage the allografts. Thus, in ABO-compatible liver transplantation humoral alloreactivity mediated by antibodies against donor HLA molecules appears to be frequently intertwined with cellular mechanisms of rejection, and to play a role in ductopenia development.
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Regulation of complement activation by C-reactive protein
Mold, C., Gewurz, H., & Du Clos, T. W. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00007-7 · Cited by 326
Cited by
Tait, B. D., Süsal, C., Gebel, H. M., Nickerson, P. W., Zachary, A. A., Claas, F. H. J., Reed, E. F., Bray, R. A., Campbell, P., Chapman, J. R., et al. (2013) · Transplantation · doi:10.1097/tp.0b013e31827a19cc · Cited by 787
Lucey, M. R., Terrault, N., Ojo, L., Hay, E. J., Neuberger, J., Blumberg, E., & Teperman, L. W. (2013) · Liver Transplantation · doi:10.1002/lt.23566 · Cited by 544
Self-citationKaneku, H., O’Leary, J. G., Banuelos, N., Jennings, L. W., Susskind, B. M., Klintmalm, G. B., & Terasaki, P. I. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12212 · Cited by 252
Lucey, M. R., Furuya, K. N., & Foley, D. P. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2200923 · Cited by 182
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Metadata
- Authors
- Musat, A. I., Agni, R. M., Wai, P. Y., Pirsch, J. D., Lorentzen, D. F., Powell, A., Leverson, G. E., Bellingham, J. M., Fernandez, L. A., Foley, D. P., Mezrich, J. D., D’Alessandro, A. M., & Lucey, M. R.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 11
- Issue
- 3
- Pages
- 500-510
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2097192629
- Cited by
- 179
- References
- 1
- FWCI
- 20.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Musat, A. I., Agni, R. M., Wai, P. Y., Pirsch, J. D., Lorentzen, D. F., Powell, A., Leverson, G. E., Bellingham, J. M., Fernandez, L. A., Foley, D. P., Mezrich, J. D., D’Alessandro, A. M., & Lucey, M. R. (2011). The Significance of Donor-Specific HLA Antibodies in Rejection and Ductopenia Development in ABO Compatible Liver Transplantation. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2010.03414.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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