The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
De Novo Donor-Specific HLA Antibodies Decrease Patient and Graft Survival in Liver Transplant Recipients
Open accessAbstract
The role of de novo donor-specific HLA antibodies (DSA) in liver transplantation remains unknown as most of the previous studies have only focused on preformed HLA antibodies. To understand the significance of de novo DSA, we designed a retrospective cohort study of 749 adult liver transplant recipients with pre- and posttransplant serum samples that were analyzed for DSA. We found that 8.1% of patients developed de novo DSA 1 year after transplant; almost all de novo DSAs were against HLA class II antigens, and the majority were against DQ antigens. In multivariable modeling, the use of cyclosporine (as opposed to tacrolimus) and low calcineurin inhibitor levels increased the risk of de novo DSA formation, while a calculated MELD score >15 at transplant and recipient age >60 years old reduced the risk. Multivariable analysis also demonstrated that patients with de novo DSA at 1-year had significantly lower patient and graft survival. In conclusion, we demonstrate that de novo DSA development after liver transplantation is an independent risk factor for patient death and graft loss.
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Sellarés, J., de Freitas, D. G., Mengel, M., Reeve, J., Einecke, G., Sis, B., Hidalgo, L. G., Famulski, K., Matas, A., & Halloran, P. F. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03840.x · Cited by 1,590
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659
Four-year Follow-up of a Prospective Trial of HLA and MICA Antibodies on Kidney Graft Survival
Terasaki, P., Ozawa, M., & Castro, R. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01644.x · Cited by 362
Self-citationLachmann, N., Terasaki, P. I., Budde, K., Liefeldt, L., Kahl, A., Reinke, P., Pratschke, J., Rudolph, B., Schmidt, D., Salama, A., et al. (2009) · Transplantation · doi:10.1097/tp.0b013e3181a44206 · Cited by 344
Self-citationBaseline Donor‐Specific Antibody Levels and Outcomes in Positive Crossmatch Kidney Transplantation
Gloor, J. M., Winters, J. L., Cornell, L. D., Fix, L. A., DeGoey, S. R., Knauer, R. M., Cosio, F. G., Gandhi, M. J., Kremers, W., & Stegall, M. D. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02985.x · Cited by 264
Human Leukocyte Antigen Antibodies and Chronic Rejection: From Association to Causation
Terasaki, P. I., & Cai, J. (2008) · Transplantation · doi:10.1097/tp.0b013e31817c4cb8 · Cited by 246
Self-citationAbu-Elmagd, K. M., Wu, G., Costa, G., Lunz, J., Martin, L., Koritsky, D. A., Murase, N., Irish, W., & Zeevi, A. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04237.x · Cited by 198
Donor-specific HLA-DQ antibodies may contribute to poor graft outcome after renal transplantation
DeVos, J. M., Gaber, A. O., Knight, R. J., Land, G. A., Suki, W. N., Gaber, L. W., & Patel, S. J. (2012) · Kidney International · doi:10.1038/ki.2012.190 · Cited by 194
Miyagawa-Hayashino, A., Yoshizawa, A., Uchida, Y., Egawa, H., Yurugi, K., Masuda, S., Minamiguchi, S., Maekawa, T., Uemoto, S., & Haga, H. (2012) · Liver Transplantation · doi:10.1002/lt.23534 · Cited by 190
Musat, A. I., Agni, R. M., Wai, P. Y., Pirsch, J. D., Lorentzen, D. F., Powell, A., Leverson, G. E., Bellingham, J. M., Fernandez, L. A., Foley, D. P., et al. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03414.x · Cited by 179
Cited by
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Thorgersen, E. B., Barratt‐Due, A., Haugaa, H., Harboe, M., Pischke, S. E., Nilsson, P. H., & Mollnes, T. E. (2019) · Hepatology · doi:10.1002/hep.30508 · Cited by 240
Metadata
- Authors
- Kaneku, H., O’Leary, J. G., Banuelos, N., Jennings, L. W., Susskind, B. M., Klintmalm, G. B., & Terasaki, P. I.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 13
- Issue
- 6
- Pages
- 1541-1548
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1492421523
- Cited by
- 252
- References
- 15
- FWCI
- 21.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: De Novo Donor-Specific HLA Antibodies Decrease Patient and Graft Survival in Liver Transplant Recipients. https://app.cochat.ai/papers/10.1111/ajt.12212
- The paper
- Kaneku, H., O’Leary, J. G., Banuelos, N., Jennings, L. W., Susskind, B. M., Klintmalm, G. B., & Terasaki, P. I. (2013). De Novo Donor-Specific HLA Antibodies Decrease Patient and Graft Survival in Liver Transplant Recipients. American Journal of Transplantation. https://doi.org/10.1111/ajt.12212
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
