The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Omalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course – a randomized, placebo‐controlled and double blind pilot study
Abstract
Background Our understanding of the pathogenic role of IgE in atopic dermatitis is incomplete. We asked whether blocking free IgE would alter the course of the disease. Patients and methods We administered either omalizumab, a humanized monoclonal mouse antibody against IgE, or placebo subcutaneously for 16 weeks to 20 atopic dermatitis patients and measured immunological and clinical disease parameters. Results Omalizumab (I) reduced free serum IgE, (II) lowered surface IgE and FcɛRI expression on different peripheral blood mononuclear cells, (III) reduced the saturation of FcɛRI with IgE, (IV) increased the number of free FcɛRI and (V) lowered the number of IgE+, but not of FcɛRI+ cells in skin. The in vivo relevance of these results is evidenced by the increase in the threshold allergen concentration required to give a type I hypersensitivity reaction in the titrated skin test. While not significantly altering the clinical disease parameters, omalizumab treatment led to an improvement of the atopy patch test results in single patients, i.e. an eczematous reaction upon epicutaneous allergen challenge. Conclusions The interference with immediate and delayed type skin tests may imply that a therapeutic benefit of omalizumab treatment, if present at all, would be seen in patients with acute rather than chronic forms of the disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“strategies aimed at depleting IgE with the anti-IgE biologic omalizumab failed to show convincing results in proof-of-concept studies and single cases107,108.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [107]
Citations
Cites
Diagnostic features of atopic dermatitis
Hanifin, J. M., & Rajka, G. (1980) · Acta Dermato-Venereologica · doi:10.2340/00015555924447 · Cited by 5,086
Williams, H. C., Leung, D. Y. M., Thestrup‐Pedersen, K., & David, T. J. (2000) · Cited by 4,597
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Leung, D. Y. M., & Bieber, T. R. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12193-9 · Cited by 1,164
Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis
Koga, C., Kabashima, K., Shiraishi, N., Kobayashi, M., & TOKURA, Y. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.111 · Cited by 680
Djukanović, R., Wilson, S. J., Kraft, M., Jarjour, N. N., Steel, M. D., Chung, K. F., Bao, W., FowlerTaylor, A., Matthews, J. G., Busse, W. W., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200312-1651oc · Cited by 644
New developments in FcεRI regulation, function and inhibition
Kraft, S., & Kinet, J. (2007) · Nature reviews. Immunology · doi:10.1038/nri2072 · Cited by 580
The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation
Holgate, S. T., Casale, T. B., Wenzel, S. E., Bousquet, J. J., Deniz, Y. M., & Reisner, C. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.11.053 · Cited by 468
Omalizumab-induced reductions in mast cell FcεRI expression and function
Beck, L. A., Marcotte, G. V., MacGlashan, D., Togias, A. G., & Saini, S. S. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.06.032 · Cited by 456
Cited by
Sorted by citations
Guidelines of care for the management of atopic dermatitis
Eichenfield, L. F., Tom, W. L., Chamlin, S. L., Feldman, S. R., Hanifin, J. M., Simpson, E. L., Berger, T. G., Bergman, J. N., Cohen, D. E., Cooper, K. D., et al. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.10.010 · Cited by 1,305
Wollenberg, A., Barbarot, S., Bieber, T., Christen‐Zaech, S., Deleuran, M., Fink‐Wagner, A., Gieler, U., Girolomoni, G., Lau, S., Muraro, A., et al. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14891 · Cited by 1,181
Guidelines of care for the management of atopic dermatitis
Sidbury, R., Davis, D. M. R., Cohen, D. E., Cordoro, K. M., Berger, T. G., Bergman, J. N., Chamlin, S. L., Cooper, K. D., Feldman, S. R., Hanifin, J. M., et al. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2014.03.030 · Cited by 888
Targeting key proximal drivers of type 2 inflammation in disease
Gandhi, N. A., Bennett, B. L., Graham, N. M. H., Pirozzi, G., Stahl, N., & Yancopoulos, G. D. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd4624 · Cited by 766
Guttman‐Yassky, E., Bissonnette, R., Ungar, B., Suárez‐Fariñas, M., Ardeleanu, M., Esaki, H., Suprun, M., Estrada, Y. D., Xu, H., Peng, X., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.08.022 · Cited by 715
Guidelines for treatment of atopic eczema (atopic dermatitis) Part I
Ring, J., Alomar, A., Bieber, T. R. M., Deleuran, M. S., Fink‐Wagner, A., Gelmetti, C., Gieler, U., Lipozenčić, J., Luger, T. A., Oranje, A. P., et al. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2012.04635.x · Cited by 682
Self-citationThe immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies
Brunner, P. M., Guttman‐Yassky, E., & Leung, D. Y. M. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.01.011 · Cited by 662
Pathophysiology of atopic dermatitis: Clinical implications
Kim, J., Kim, B. E., & Leung, D. Y. M. (2019) · Allergy and Asthma Proceedings · doi:10.2500/aap.2019.40.4202 · Cited by 655
Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
Bieber, T. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00266-6 · Cited by 623
Cellular and molecular immunologic mechanisms in patients with atopic dermatitis
Werfel, T., Allam, J., Biedermann, T., Eyerich, K., Gilles, S., Guttman‐Yassky, E., Hoetzenecker, W., Knol, E. F., Simon, H., Wollenberg, A., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.010 · Cited by 603
Commonality of the IL-4/IL-13 pathway in atopic diseases
Gandhi, N. A., Pirozzi, G., & Graham, N. M. H. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1298443 · Cited by 493
Suárez-Fariñas, M., Dhingra, N., Gittler, J., Shemer, A., Cardinale, I., de Guzman Strong, C., Krueger, J. G., & Guttman-Yassky, E. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.046 · Cited by 483
Atopic dermatitis: A practice parameter update 2012
Schneider, L. C., Tilles, S. A., Lio, P., Boguniewicz, M., Beck, L. A., LeBovidge, J., Novak, N., Bernstein, D., Blessing-Moore, J., Khan, D. A., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.672 · Cited by 420
Wollenberg, A., Oranje, A. P., Deleuran, M. S., Simon, D., Szalai, Z. Z., Kunz, B., Svensson, Å., Barbarot, S., von Kobyletzki, L., Taı̈eb, A., et al. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13599 · Cited by 396
Fajt, M. L., & Wenzel, S. E. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1871 · Cited by 359
Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council
Renert-Yuval, Y., Thyssen, J. P., Bissonnette, R., Bieber, T., Kabashima, K., Hijnen, D., & Guttman-Yassky, E. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.01.013 · Cited by 350
Guttman‐Yassky, E., Renert‐Yuval, Y., & Brunner, P. M. (2025) · The Lancet · doi:10.1016/s0140-6736(24)02519-4 · Cited by 357
Immunology of atopic eczema: overcoming the Th1/Th2 paradigm
Eyerich, K., & Novak, N. (2013) · Allergy · doi:10.1111/all.12184 · Cited by 329
Basophils and allergic inflammation
Siracusa, M. C., Kim, B., Spergel, J. M., & Artis, D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.07.046 · Cited by 320
Therapies for allergic inflammation: refining strategies to induce tolerance
Akdiş, C. A. (2012) · Nature Medicine · doi:10.1038/nm.2754 · Cited by 295
Update on the Pathogenesis and Therapy of Atopic Dermatitis
Li, H., Zhang, Z., Zhang, H., Guo, Y., & Yao, Z. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08880-3 · Cited by 277
A basophil-neuronal axis promotes itch
Wang, F., Trier, A. M., Li, F., Kim, S., Chen, Z. B., Chai, J. N., Mack, M. R., Morrison, S. A., Hamilton, J. D., Baek, J. O., et al. (2021) · Cell · doi:10.1016/j.cell.2020.12.033 · Cited by 267
Chu, A. W. L., Wong, M. M., Rayner, D. G., Guyatt, G. H., Martinez, J. P. D., Ceccacci, R., Zhao, I. X., McMullen, E. P., Srivastava, A., Wang, J., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.08.029 · Cited by 179
Immunologic, microbial, and epithelial interactions in atopic dermatitis
Brunner, P. M., Leung, D. Y. M., & Guttman‐Yassky, E. (2017) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.09.055 · Cited by 166
Systemic Treatment of Adult Atopic Dermatitis: A Review
Megna, M., Napolitano, M., Patruno, C., Villani, A., Balato, A., Monfrecola, G., Ayala, F., & Balato, N. (2016) · Dermatology and Therapy · doi:10.1007/s13555-016-0170-1 · Cited by 161
Management of Itch in Atopic Dermatitis
Hong, J., Buddenkotte, J., Berger, T. G., & Steinhoff, M. S. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.05.002 · Cited by 148
Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis
Kim, J. E., Kim, J., Cho, D., & Park, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081234 · Cited by 153
Targeting immunoglobulin E in atopic dermatitis: A review of the existing evidence
Wollenberg, A., Thomsen, S. F., Lacour, J. ‐., Jaumont, X., & Lazarewicz, S. (2021) · World Allergy Organization Journal · doi:10.1016/j.waojou.2021.100519 · Cited by 142
Efficacy of omalizumab in patients with atopic dermatitis: A systematic review and meta-analysis
Wang, H.-H., Li, Y., & Huang, Y. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.038 · Cited by 134
Chan, S., Cornelius, V., Cro, S., Harper, J. I., & Lack, G. (2020) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2019.4476 · Cited by 130
Biomarkers for evaluation of mast cell and basophil activation
Kabashima, K., Nakashima, C., Nonomura, Y., Otsuka, A., Cardamone, C., Parente, R., Feo, G. D., & Triggiani, M. (2018) · Immunological Reviews · doi:10.1111/imr.12639 · Cited by 122
Systemic treatments in the management of atopic dermatitis: A systematic review and meta‐analysis
Siegels, D., Heratizadeh, A., Abraham, S., Binnmyr, J., Brockow, K., Irvine, A. D., Halken, S., Mortz, C. G., Flohr, C., Schmid‐Grendelmeier, P., et al. (2020) · Allergy · doi:10.1111/all.14631 · Cited by 124
Atopic dermatitis - from new pathophysiologic insights to individualized therapy
Novak, N., & Simon, D. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02571.x · Cited by 114
New pathogenic and therapeutic paradigms in atopic dermatitis
Malajian, D., & Guttman‐Yassky, E. (2014) · Cytokine · doi:10.1016/j.cyto.2014.11.023 · Cited by 115
IgE-Mediated Multimorbidities in Allergic Asthma and the Potential for Omalizumab Therapy
Humbert, M. J. C., Bousquet, J., Bachert, C., Palomares, Ó., Pfister, P., Kottakis, I., Jaumont, X., Thomsen, S. F., & Papadopoulos, N. G. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.02.030 · Cited by 113
EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders
Boyman, O., Kaegi, C., Akdiş, M., Bavbek, S., Bossios, A., Chatzipetrou, A., Eiwegger, T., Firinu, D., Harr, T., Knol, E. F., et al. (2015) · Allergy · doi:10.1111/all.12616 · Cited by 105
Systemic therapy for atopic dermatitis
Simon, D., & Bieber, T. R. M. (2013) · Allergy · doi:10.1111/all.12339 · Cited by 97
Drug Evaluation Review: Dupilumab in Atopic Dermatitis
Hamilton, J. D., Ungar, B., & Guttman‐Yassky, E. (2015) · Immunotherapy · doi:10.2217/imt.15.69 · Cited by 94
The Multi-Modal Immune Pathogenesis of Atopic Eczema
Eyerich, K., Eyerich, S., & Biedermann, T. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.10.006 · Cited by 90
Kawakami, T., & Blank, U. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601476 · Cited by 87
Clinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87
Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis
Snast, I., Reiter, O., Hodak, E., Friedland, R., Mimouni, D., & Leshem, Y. A. (2017) · American Journal of Clinical Dermatology · doi:10.1007/s40257-017-0324-7 · Cited by 81
Systemic therapy of atopic dermatitis
Bußmann, C., & Novak, N. (2017) · Allergologie select · doi:10.5414/alx01285e · Cited by 80
Treatment of Eczema: Corticosteroids and Beyond
Chong, M., & Fonacier, L. S. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8486-7 · Cited by 73
Omalizumab for atopic dermatitis: case series and a systematic review of the literature
Holm, J. G., Agner, T., Sand, C., & Thomsen, S. F. (2017) · International Journal of Dermatology · doi:10.1111/ijd.13353 · Cited by 71
Immunoadsorption in Dermatology
Meyersburg, D., Schmidt, E., Kasperkiewicz, M., & Zillikens, D. (2012) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1744-9987.2012.01075.x · Cited by 71
Jia, T., Che, D., Zheng, Y., Zhang, H., Li, Y., Zhou, T., Peng, B., Du, X., Zhu, L., An, J., et al. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.06.201 · Cited by 69
Emerging Treatment Options in Atopic Dermatitis: Systemic Therapies
Nygaard, U., Vestergaard, C., & Deleuran, M. S. (2017) · Dermatology · doi:10.1159/000484406 · Cited by 67
Targeting IgE in Severe Atopic Dermatitis with a Combination of Immunoadsorption and Omalizumab
Zink, A., Gensbaur, A., Zirbs, M., Seifert, F., Suarez, I., Mourantchanian, V, Weidinger, S., Mempel, M., Ring, J., & Ollert, M. (2016) · Acta Dermato Venereologica · doi:10.2340/00015555-2165 · Cited by 67
Scoping systematic review of treatments for eczema
Nankervis, H., Thomas, K. S., Delamere, F. M., Barbarot, S., Rogers, N. K., & Williams, H. C. (2016) · Programme Grants for Applied Research · doi:10.3310/pgfar04070 · Cited by 68
Biological Treatments in Atopic Dermatitis
Montes‐Torres, A., Llamas‐Velasco, M., Pérez-Plaza, A., Solano-López, G., & Sánchez-Pérez, J. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4040593 · Cited by 66
Rajagopalan, M., De, A., Godse, K. V., Shankar, D. K., Zawar, V. P., Sharma, N., Mukherjee, S., Sarda, A., & Dhar, S. (2019) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_683_18 · Cited by 65
Biological therapies for atopic dermatitis: An update�(Review)
Deleanu, D. M., & Nedelea, I. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6989 · Cited by 63
Systemic treatments for eczema: a network meta-analysis
Sawangjit, R., Dilokthornsakul, P., Lloyd-Lavery, A., Lai, N. M., Dellavalle, R. P., & Chaiyakunapruk, N. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013206.pub2 · Cited by 65
Omalizumab, an anti-immunoglobulin E antibody: state of the art
Incorvaia, C., Mauro, M., Russello, M., Formigoni, C., Ridolo, E., & Riario-Sforza (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s49409 · Cited by 55
The adaptive immune system in atopic dermatitis and implications on therapy
Roesner, L. M., Werfel, T., & Heratizadeh, A. (2016) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2016.1165093 · Cited by 55
Hill, M. K., Pishkenari, A. K., Braunberger, T. L., Armstrong, A. W., & Dunnick, C. A. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.07.002 · Cited by 54
Biologic Therapy for Atopic Dermatitis: Moving Beyond the Practice Parameter and Guidelines
Boguniewicz, M. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.08.031 · Cited by 53
Past, present, and future for biologic intervention in atopic dermatitis
Howell, M. D., Parker, M. L., Mustelin, T., & Ranade, K. (2015) · Allergy · doi:10.1111/all.12632 · Cited by 51
Systemic therapy of childhood atopic dermatitis
Slater, N. A., & Morrell, D. S. (2014) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2014.12.005 · Cited by 50
Targeting the T Helper 2 Inflammatory Axis in Atopic Dermatitis
Moreno, A. S., McPhee, R. A., Arruda, L. K., & Howell, M. D. (2016) · International Archives of Allergy and Immunology · doi:10.1159/000451083 · Cited by 46
New and emerging targeted systemic therapies: a new era for atopic dermatitis
Lee, D. E., Clark, A. K., Tran, K. A., & Shi, V. Y. (2017) · Journal of Dermatological Treatment · doi:10.1080/09546634.2017.1373736 · Cited by 48
The evolving landscape of biologic therapies for atopic dermatitis: Present and future perspective
David, E., Ungar, B., Renert‐Yuval, Y., Facheris, P., DUCA, E. D., & Guttman‐Yassky, E. (2023) · Clinical & Experimental Allergy · doi:10.1111/cea.14263 · Cited by 49
Leitlinie Neurodermitis [atopisches Ekzem; atopische Dermatitis]
Werfel, T., Aberer, W., Ahrens, F., Matthias, A., Biedermann, T., Diepgen, T., Regina, F., Gieler, U., Heratizadeh, A., Kahle, J., et al. (2015) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12884 · Cited by 45
Update “Systemic treatment of atopic dermatitis” of the S2k‐guideline on atopic dermatitis
Werfel, T., Heratizadeh, A., Aberer, W., Ahrens, F., Augustin, M., Biedermann, T., Diepgen, T. L., Fölster‐Holst, R., Kahle, J., Kapp, A., et al. (2021) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.14371 · Cited by 46
Review of Systemic Treatment Options for Adult Atopic Dermatitis
Gooderham, M., Lynde, C. W., Papp, K. A., Bourcier, M., Guenther, L., Gulliver, W. P. F., Hong, C.-H., Poulin, Y. P., Sussman, G. L., & Vender, R. B. (2016) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/1203475416670364 · Cited by 46
Sánchez‐Ramón, S., Eguíluz‐Gracia, I., Rodriguez-Mazariego, M. E., Paravisini, A., Zubeldia, J. M., Gil-Herrera, J., Fernández‐Cruz, E., & Suárez‐Fernández, R. (2013) · PubMed · Cited by 44
Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review
Barbarot, S., Rogers, N. K., Abuabara, K., Aubert, H., Chalmers, J. R., Flohr, C., Hanifin, J. M., Naldi, L., Margolis, D. J., Paul, C. F., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.05.043 · Cited by 44
IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease
Charles, N., & Blank, U. (2025) · Immunological Reviews · doi:10.1111/imr.70024 · Cited by 42
Actualización en dermatitis atópica. Propuesta de algoritmo de actuación
Garnacho-Saucedo, G. M., Salido‐Vallejo, R., & Moreno‐Giménez, J. C. (2012) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2011.12.008 · Cited by 42
Nankervis, H., Thomas, K. S., Delamere, F. M., Barbarot, S., Smith, S. J., Rogers, N. K., & Williams, H. C. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14999 · Cited by 42
Immunologic Targets in Atopic Dermatitis and Emerging Therapies: An Update
Wang, D., & Beck, L. A. (2016) · American Journal of Clinical Dermatology · doi:10.1007/s40257-016-0205-5 · Cited by 44
Anti-IgE therapy and severe atopic dermatitis: A pediatric perspective
Lacombe‐Barrios, J., Bégin, P., Paradis, L. P., Hatami, A., Paradis, J., & Roches, A. D. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.05.035 · Cited by 41
Autoreactive T cells and their role in atopic dermatitis
Carlier, T. D. B., Badloe, F. M. S., Ring, J., Gutermuth, J., & Krohn, I. K. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102634 · Cited by 41
New and Emerging Therapies for Pediatric Atopic Dermatitis
Nguyen, H. L., Anderson, K., & Tollefson, M. M. (2019) · Pediatric Drugs · doi:10.1007/s40272-019-00342-w · Cited by 41
Current and Future Monoclonal Antibodies in the Treatment of Atopic Dermatitis
Chun, P. I. F., & Lehman, H. K. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08802-9 · Cited by 38
Biologics in patients with skin diseases
Veilleux, M. S., & Shear, N. H. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.03.012 · Cited by 38
Novel Targeted Biological Agents for the Treatment of Atopic Dermatitis
Yang, N., Chen, Z., Zhang, X., & Shi, Y. (2021) · BioDrugs · doi:10.1007/s40259-021-00490-x · Cited by 37
Target-oriented therapy: Emerging drugs for atopic dermatitis
Lauffer, F., & Ring, J. (2016) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2016.1146681 · Cited by 36
Skabytska, Y., Kaesler, S., Volz, T., & Biedermann, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0544-y · Cited by 37
Prescriptions for atopic dermatitis: oral corticosteroids remain commonplace
Alexander, T., Maxim, E., Cardwell, L. A., Chawla, A., & Feldman, S. R. (2017) · Journal of Dermatological Treatment · doi:10.1080/09546634.2017.1365112 · Cited by 36
Eosinophils—from cradle to grave
Jeseňák, M., Diamant, Z., Simon, D., Tufvesson, E., Seys, S., Mukherjee, M., Lacy, P., Vijverberg, S. J. H., Slisz, T., Šedivá, A., et al. (2023) · Allergy · doi:10.1111/all.15884 · Cited by 38
Anti-IgE Therapy: Clinical Utility and Mechanistic Insights
Logsdon, S. L., & Oettgen, H. C. (2015) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-13725-4_3 · Cited by 35
Atopic Dermatitis: Update and Proposed Management Algorithm
Garnacho-Saucedo, G. M., Salido‐Vallejo, R., & Moreno‐Giménez, J. C. (2013) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2012.11.001 · Cited by 35
Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression
Weiss, D., Schaschinger, M., Ristl, R., Gruber, R. W., Kopp, T., Stingl, G., & Bangert, C. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.07.047 · Cited by 35
Self-citationRelative efficacy of systemic treatments for atopic dermatitis
Seger, E. W., Wechter, T., Strowd, L. C., & Feldman, S. R. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.09.053 · Cited by 35
Heinl, D., Chalmers, J. R., Nankervis, H., & Apfelbacher, C. (2015) · Acta Dermato Venereologica · doi:10.2340/00015555-2322 · Cited by 33
Current novel approaches in systemic therapy of atopic dermatitis
Werfel, T., & Biedermann, T. (2015) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000199 · Cited by 34
Treatments for Childhood Atopic Dermatitis: an Update on Emerging Therapies
Chu, C. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08799-1 · Cited by 36
Insights into atopic dermatitis pathogenesis lead to newly approved systemic therapies
Trier, A. M., & Kim, B. (2022) · British Journal of Dermatology · doi:10.1093/bjd/ljac016 · Cited by 32
Toledo, F., Silvestre, J. F., & Muñoz, C. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04326.x · Cited by 31
IgE-Specific Immunoadsorption for Treatment of Recalcitrant Atopic Dermatitis
Kasperkiewicz, M., Süfke, S., Schmidt, E., & Zillikens, D. (2014) · JAMA Dermatology · doi:10.1001/jamadermatol.2014.2082 · Cited by 30
New treatments in atopic dermatitis update
Gallagher, K., Halperin-Goldstein, S., & Paller, A. S. (2025) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2025.06.020 · Cited by 29
A review of omalizumab for the management of severe asthma
Shih-Lung, C., & Lin, C. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s112208 · Cited by 27
Radi, G., Campanati, A., Diotallevi, F., Martina, E., Marani, A., & Offidani, A. (2022) · Biomedicines · doi:10.3390/biomedicines10112700 · Cited by 27
Future treatment options for atopic dermatitis – Small molecules and beyond
Schäkel, K., Döbel, T., & Bosselmann, I. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.11.009 · Cited by 28
Insights into the Implications of Coexisting Type 2 Inflammatory Diseases
McCormick, J. P., & Lee, J. T. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s311640 · Cited by 27
Guidelines for Treatment of Atopic Eczema (Atopic Dermatitis)
Alomar, A., Bieber, T. R. M., Deleuran, M. S., Fink‐Wagner, A., Gieler, U., Lipozenčić, J., Simon, D., Szepietowski, J. C., Darsow, U. G., Biederstein, A. A., et al. (2011) · Cited by 26
Omalizumab for atopic dermatitis: evidence for and against its use
Holm, J. G., & Thomsen, S. F. (2019) · Giornale Italiano di Dermatologia e Venereologia · doi:10.23736/s0392-0488.19.06302-8 · Cited by 26
Systemic Agents for Severe Atopic Dermatitis in Children
Notaro, E., & Sidbury, R. (2015) · Pediatric Drugs · doi:10.1007/s40272-015-0150-4 · Cited by 25
Metadata
- Authors
- Heil, P. M., Maurer, D., Klein, B., Hultsch, T., & Stingl, G.
- Affiliations
- Medical University of Vienna (AT)
- Johannes Gutenberg University Mainz (DE)
- Venue
- JDDG: Journal der Deutschen Dermatologischen Gesellschaft
- Publisher
- Wiley
- Published
- 2010-11-25
- Volume
- 8
- Issue
- 12
- Pages
- 990-998
- ISSN
- 1610-0379 (ISSN-L)
- 1610-0387
- OpenAlex
- W1512818159
- Cited by
- 197
- References
- 38
- Citations by year
- 2026: 1 · 2025: 11 · 2024: 3 · 2023: 10 · 2022: 6 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 12 · 2017: 19 · 2016: 24 · 2015: 24 · 2014: 13 · 2013: 15 · 2012: 16
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JDDG Journal der Deutschen Dermatologischen Gesellschaft (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- omalizumab, atopic dermatitis, IgE, FcεRI, immediate hypersensitivity, atopy patch test, chronic atopic dermatitis
- MeSH terms
- Omalizumab, Adolescent, Adult, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal, Dermatitis, Atopic, Double-Blind Method, Female, Humans, Immunoglobulin E, Injections, Subcutaneous, Male, Middle Aged, Pilot Projects, Skin Tests, Placebo Effect, Treatment Outcome, Anti-Allergic Agents, Young Adult, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
