The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting: Affective disorders in gastrointestinal diseases
Abstract
OBJECTIVES: To evaluate state and trait form of anxiety and current depression in patients affected by gastrointestinal diseases. METHODS: We studied 1641 outpatients with gastrointestinal disorders, consecutively referred to our Internal Medicine outpatients from 1997 to 2005. State and trait anxiety were assessed by the State and Trait Anxiety Inventory. Current depression was assessed by the Zung self-rating depression scale. RESULTS: Among patients, 1379 (84.1%) showed state anxiety, 1098 (67%) showed trait anxiety and 442 (27%) showed current depression. The number of gastrointestinal diseases was directly correlated to state anxiety (p < 0.001) and trait anxiety (p = 0.04). Females showed higher levels of anxiety and depression than males (p < 0.001). State anxiety was related to food allergies (p < 0.001), small intestinal bacterial overgrowth (SIBO) (p = 0.001), Hp infection (p = 0.01) and ulcerative colitis in active phase (p = 0.03). Trait anxiety was related to irritable bowel syndrome (IBS) (p < 0.001), Helicobacter pylori (Hp) infection (p = 0.001), food allergies (p = 0.001) and SIBO (p = 0.001). Current depression was related to IBS (p < 0.001) and coeliac disease (p = 0.01), SIBO (p = 0.02). A predicted probability of 0.77 +/- 0.16 to have state anxiety, of 0.66 +/- 0.12 to have trait anxiety and of 0.39 +/- 0.14 to have depression was found in these patients. CONCLUSIONS: Most of the patients who seek medical consultation for gastrointestinal problems show an associated affective disorder. These patients should be managed by a team including gastroenterologists, psychologists and/or psychiatrists, or by a gastroenterologist having expertise in the treatment of psychological disorders.
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“The pooled mean rate for all the studies reporting percentages (study n=8; total n=1,069) was 28.2% (± 2.7, 95% CI) (18, 27-29, 32, 33, 36, 39).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
In the citing paper
“The pooled mean rate of depressive symptoms for those with inactive IBD was 19.9% (± 2.05, 95% CI) (study n=10; total n=1,132) (18, 27-29, 32, 33, 36, 39, 40, 48).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
In the citing paper
“The pooled mean rate of depressive symptoms during active IBD was 34.7% (study n=5; total n=319) (18, 27, 29, 40, 48).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
In the citing paper
“Of the remaining 15, 11 reported significantly higher rates or levels of anxiety in participants with active IBD compared to those with inactive IBD (n=13,585) (4, 18, 20, 27, 29, 31, 38, 41, 42, 44, 45).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
In the citing paper
“Of the remaining 17 studies, 12 reported significantly higher rates or levels of depression for those with active IBD (n=13,553) (18, 20, 27, 29, 31, 34, 35, 38, 41, 43, 45, 48).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [27]
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Metadata
- Authors
- Addolorato, G., Mirijello, A., D’Angelo, C., Leggio, L., Ferrulli, A., Abenavoli, L., Vonghia, L., Cardone, S., Leso, V., Cossari, A., Capristo, E., & Gasbarrini, G.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- University of Calabria (IT)
- ORCID
- Venue
- International Journal of Clinical Practice
- Publisher
- Hindawi Limited
- Published
- 2008-04-18
- Volume
- 62
- Issue
- 7
- Pages
- 1063-1069
- ISSN
- 1368-5031 (ISSN-L)
- OpenAlex
- W1573315265
- Cited by
- 150
- References
- 43
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 5
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- state anxiety, trait anxiety, depression, gastrointestinal diseases, irritable bowel syndrome, small intestinal bacterial overgrowth, Helicobacter pylori infection, celiac disease, food allergy, ulcerative colitis, sex differences, mood disorders, psychosomatic medicine
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anxiety Disorders, Depressive Disorder, Female, Gastrointestinal Diseases, Humans, Italy, Male, Middle Aged, Outpatients, Psychiatric Status Rating Scales, Psychometrics, Young Adult
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