Leggio, Lorenzo

Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study

Terraneo, A., Leggio, L., Saladini, M., Ermani, M., Bonci, A., & Gallimberti, L. (2016) · European Neuropsychopharmacology

Transcranial Magnetic Stimulation StudiesSubstance Abuse Treatment and Outcomes

Cited by 281

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay

Lee, M. R., Scheidweiler, K. B., Diao, X. X., Akhlaghi, F., Cummins, A., Huestis, M. A., Leggio, L., & Averbeck, B. B. (2018) · Molecular Psychiatry

Neuroendocrine regulation and behaviorAdvanced Drug Delivery Systems

Cited by 235

The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

Chuong, V., Farokhnia, M., Khom, S., Pince, C. L., Elvig, S. K., Vlkolinsky, R., Marchette, R. C. N., Koob, G. F., Roberto, M., Vendruscolo, L. F., et al. (2023) · JCI Insight

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 214

Baclofen in the Treatment of Alcohol Withdrawal Syndrome: A Comparative Study vs Diazepam

Addolorato, G., Leggio, L., Abenavoli, L., Agabio, R., Caputo, F., Capristo, E., Colombo, G., Gessa, G. L., & Gasbarrini, G. (2006) · The American Journal of Medicine

Alcoholism and Thiamine DeficiencySubstance Abuse Treatment and Outcomes

Cited by 203

The CRF1 antagonist verucerfont in anxious alcohol-dependent women: translation of neuroendocrine, but not of anti-craving effects

Schwandt, M. L., Cortes, C. R., Kwako, L. E., George, D. T., Momenan, R., Sinha, R., Grigoriadis, D. E., Pich, E. M., Leggio, L., & Heilig, M. (2016) · Neuropsychopharmacology

Substance Abuse Treatment and OutcomesStress Responses and Cortisol

Cited by 159

State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting: Affective disorders in gastrointestinal diseases

Addolorato, G., Mirijello, A., D’Angelo, C., Leggio, L., Ferrulli, A., Abenavoli, L., Vonghia, L., Cardone, S., Leso, V., Cossari, A., et al. (2008) · International Journal of Clinical Practice

Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesGastrointestinal motility and disorders

Cited by 150

The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence

Suchankova, P., Yan, J., Schwandt, M. L., Stangl, B. L., Caparelli, E. C., Momenan, R., Jerlhag, E., Engel, J. A., Hodgkinson, C. A., Egli, M., et al. (2015) · Translational Psychiatry

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 146

Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

Lee, M. R., Shnitko, T. A., Blue, S. W., Kaucher, A. V., Winchell, A. J., Erikson, D. W., Grant, K. A., & Leggio, L. (2020) · Nature Communications

Neuroendocrine regulation and behaviorOlfactory and Sensory Function Studies

Cited by 132

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: Preclinical safety experiments and a phase 1b human laboratory study

Lee, M. R., Tapocik, J. D., Ghareeb, M., Schwandt, M. L., Dias, A. A., Le, A. N., Cobbina, E., Farinelli, L. A., Bouhlal, S., Farokhnia, M., et al. (2020) · Molecular Psychiatry

Regulation of Appetite and ObesityAlcohol Consumption and Health Effects

Cited by 129

Noradrenergic targets for the treatment of alcohol use disorder

Haass-Koffler, C. L., Swift, R. M., & Leggio, L. (2018) · Psychopharmacology

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 117

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., et al. (2019) · PLOS Biology

Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

Cited by 104

The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective

de Beaurepaire, R., Sinclair, J. M. A., Heydtmann, M., Addolorato, G., Aubin, H.-J., Beraha, E. M., Caputo, F., Chick, J. D., de La Selle, P., Franchitto, N., et al. (2019) · Frontiers in Psychiatry

Substance Abuse Treatment and OutcomesAlcohol Consumption and Health Effects

Cited by 95

Gabapentin enacarbil extended-release for alcohol use disorder: a randomized, double-blind, placebo-controlled, multisite trial assessing efficacy and safety

Falk, D. E., Ryan, M. L., Fertig, J. B., Devine, E. G., Cruz, R., Brown, E. S., Burns, H., Salloum, I. M., Newport, D. J., Mendelson, J., et al. (2019) · Alcoholism: Clinical and Experimental Research

Substance Abuse Treatment and OutcomesAlcohol Consumption and Health Effects

Cited by 89

Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000–2021

Danpanichkul, P., Díaz, L. A., Suparan, K., Tothanarungroj, P., Sirimangklanurak, S., Auttapracha, T., Blaney, H. L., Sukphutanan, B., Pang, Y., Kongarin, S., et al. (2025) · Clinical and Molecular Hepatology

Alcohol Consumption and Health EffectsSubstance Abuse Treatment and Outcomes

Cited by 85

Pharmacological approaches to reducing craving in patients with alcohol use disorders

Haass-Koffler, C. L., Leggio, L., & Kenna, G. A. (2014) · CNS Drugs

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 83

The microbiota, the gut and the brain in eating and alcohol use disorders: A ‘Ménage à Trois’?

Temko, J. E., Bouhlal, S., Farokhnia, M., Lee, M. R., Cryan, J. F., & Leggio, L. (2017) · Alcohol and Alcoholism

Gut microbiota and healthEating Disorders and Behaviors

Cited by 76

A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans

Aoun, E. G., Jimenez, V. A., Vendruscolo, L. F., Walter, N. A. R., Barbier, E., Ferrulli, A., Haass-Koffler, C. L., Darakjian, P., Lee, M. R., Addolorato, G., et al. (2018) · Molecular Psychiatry

Alcohol Consumption and Health EffectsNeurotransmitter Receptor Influence on Behavior

Cited by 60

Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex may improve symptoms of anhedonia in individuals with cocaine use disorder: a pilot study

Pettorruso, M., Spagnolo, P. A., Leggio, L., Janiri, L., Di Giannantonio, M., Gallimberti, L., Bonci, A., & Martinotti, G. (2018) · Brain Stimulation

Transcranial Magnetic Stimulation StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 51

Pharmacotherapy for alcoholic patients with alcoholic liver disease

Vuittonet, C. L., Halse, M., Leggio, L., Fricchione, S. B., Brickley, M., Haass-Koffler, C. L., Tavares, T., Swift, R. M., & Kenna, G. A. (2014) · American Journal of Health-System Pharmacy

Alcohol Consumption and Health EffectsSubstance Abuse Treatment and Outcomes

Cited by 51

The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study

Farokhnia, M., Browning, B. D., Crozier, M. E., Sun, H., Akhlaghi, F., & Leggio, L. (2022) · Addiction Biology

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 46

Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study

Lee, M. R., Sheskier, M. B., Farokhnia, M., Feng, N., Marenco, S., Lipska, B. K., & Leggio, L. (2018) · Psychoneuroendocrinology

Neuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Cited by 44

Reduced drug use as an alternative valid outcome in individuals with stimulant use disorders: Findings from 13 multisite randomized clinical trials

Amin‐Esmaeili, M., Farokhnia, M., Susukida, R., Leggio, L., Johnson, R. M., Crum, R. M., & Mojtabai, R. (2024) · Addiction

Substance Abuse Treatment and OutcomesOpioid Use Disorder Treatment

Cited by 43

Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies

Farokhnia, M., Rentsch, C. T., Chuong, V., McGinn, M. A., Elvig, S. K., Douglass, E. A., Gonzalez, L. A., Sanfilippo, J. E., Marchette, R. C. N., Tunstall, B. J., et al. (2022) · Molecular Psychiatry

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 41

Defining the role of corticotropin releasing factor binding protein in alcohol consumption

Haass-Koffler, C. L., Henry, A. T., Melkus, G., Simms, J. A., Naemmuddin, M., Nielsen, C. K., Lasek, A. W., Magill, M., Schwandt, M. L., Momenan, R., et al. (2016) · Translational Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 33