The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Mammalian xanthine oxidoreductase – mechanism of transition from xanthine dehydrogenase to xanthine oxidase
Abstract
Reactive oxygen species are generated by various biological systems, including NADPH oxidases, xanthine oxidoreductase, and mitochondrial respiratory enzymes, and contribute to many physiological and pathological phenomena. Mammalian xanthine dehydrogenase (XDH) can be converted to xanthine oxidase (XO), which produces both superoxide anion and hydrogen peroxide. Recent X‐ray crystallographic and site‐directed mutagenesis studies have revealed a highly sophisticated mechanism of conversion from XDH to XO, suggesting that the conversion is not a simple artefact, but rather has a function in mammalian organisms. Furthermore, this transition seems to involve a thermodynamic equilibrium between XDH and XO; disulfide bond formation or proteolysis can then lock the enzyme in the XO form. In this review, we focus on recent advances in our understanding of the mechanism of conversion from XDH to XO.
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Cites
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Cited by
The mononuclear molybdenum enzymes
Hille, R., Hall, J., & Basu, P. (2014) · Chemical Reviews · doi:10.1021/cr400443z · Cited by 1,738
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
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ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
Snezhkina, A. V., Kudryavtseva, A. V., Kardymon, O. L., Savvateeva, M. V., Melnikova, N. V., Krasnov, G. S., & Dmitriev, A. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6175804 · Cited by 934
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans
Marrocco, I., Altieri, F., & Peluso, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6501046 · Cited by 855
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Metadata
- Authors
- Nishino, T., Okamoto, K., Eger, B. T., Pai, E. F., & Nishino, T.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2008-06-28
- Volume
- 275
- Issue
- 13
- Pages
- 3278-3289
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2107858654
- Cited by
- 384
- References
- 72
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nishino, T., Okamoto, K., Eger, B. T., Pai, E. F., & Nishino, T. (2008). Mammalian xanthine oxidoreductase – mechanism of transition from xanthine dehydrogenase to xanthine oxidase. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2008.06489.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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