Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

Murry, C. E., Jennings, R. B., & Reimer, K. A. (1986) · Circulation · doi:10.1161/01.cir.74.5.1124 · Cited by 7,813 · see citing works

Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning

Zhao, Z., Corvera, J. S., Halkos, M. E., Kerendi, F., Wang, N.-P., Guyton, R. A., & Vinten‐Johansen, J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01064.2002 · Cited by 2,073 · see citing works

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

Brunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,193 · see citing works

‘Ischemic tolerance’ phenomenon found in the brain

Kitagawa, K., Matsumoto, M., Tagaya, M., Hata, R., Ueda, H., Niinobe, M., Handa, N., Fukunaga, R., Kimura, K., Mikoshiba, K., et al. (1990) · Brain Research · doi:10.1016/0006-8993(90)90189-i · Cited by 1,090 · see citing works

Neuroprotection in Ischemia

Xiong, Z., Zhu, X., Chu, X., Minami, M., Hey, J. G., Wei, W., MacDonald, J. F., Wemmie, J. A., Price, M. P., Welsh, M. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.08.026 · Cited by 1,026 · see citing works

Postconditioning the Human Heart

Staat, P., Rioufol, G., Piot, C. A., Cottin, Y., Cung, T. T., L’Huillier, I., Aupetit, J., Bonnefoy‐Cudraz, E., Finet, G., André‐Fouët, X., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.558122 · Cited by 1,004 · see citing works

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

Digicaylioglu, M., & Lipton, S. A. (2001) · Nature · doi:10.1038/35088074 · Cited by 932 · see citing works

Ischemic tolerance and endogenous neuroprotection

Dirnagl, U., Simon, R. P., & Hallenbeck, J. M. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00071-7 · Cited by 791 · see citing works

Cerebral preconditioning and ischaemic tolerance

Gidday, J. M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1927 · Cited by 751 · see citing works

Toward Wisdom From Failure: Lessons From Neuroprotective Stroke Trials and New Therapeutic Directions

Gladstone, D., Black, S., & Hakim, A. (2002) · Stroke · doi:10.1161/01.str.0000025518.34157.51 · Cited by 685 · see citing works

Inflammation in stroke and focal cerebral ischemia

Huang, J., Upadhyay, U. M., & Tamargo, R. J. (2006) · Surgical Neurology · doi:10.1016/j.surneu.2005.12.028 · Cited by 649 · see citing works

Cardioprotective Function of Inducible Nitric Oxide Synthase and Role of Nitric Oxide in Myocardial Ischemia and Preconditioning: an Overview of a Decade of Research

Bolli, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1462 · Cited by 597 · see citing works

Induced Tolerance to Ischemia in Gerbil Hippocampal Neurons

Kirino, T., Tsujita, Y., & Tamura, A. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.62 · Cited by 579 · see citing works

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works

Ischemic preconditioning protects by activating prosurvival kinases at reperfusion

Hausenloy, D. J., Tsang, A., Mocanu, M. M., & Yellon, D. M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00374.2004 · Cited by 512 · see citing works

Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene Expression

Barone, F. C., White, R. F., Spera, P. A., Ellison, J. A., Currie, R. W., Wang, X., & Feuerstein, G. (1998) · Stroke · doi:10.1161/01.str.29.9.1937 · Cited by 485 · see citing works

Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

Murakami, K., Kondo, T., 川瀬, 誠., Li, Y., Sato, S., Chen, S. F., & Chan, P. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00205.1998 · Cited by 467 · see citing works

The Reperfusion Injury Salvage Kinase Pathway: A Common Target for Both Ischemic Preconditioning and Postconditioning

Hausenloy, D. J., Tsang, A., & Yellon, D. M. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.03.001 · Cited by 449 · see citing works

P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion.

Okada, Y., Copeland, B. R., Mori, E., Tung, M. M., Thomas, W. S., & del Zoppo, G. J. (1994) · Stroke · doi:10.1161/01.str.25.1.202 · Cited by 435 · see citing works

Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states

Stenzel‐Poore, M. P., Stevens, S. L., Xiong, Z., Lessov, N. S., Harrington, C. A., Mori, M., Meller, R., Rosenzweig, H. L., Tobar, E., Shaw, T., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14412-1 · Cited by 394 · see citing works

The role of mitochondria in protection of the heart by preconditioning

Halestrap, A. P., Clarke, S. J., & Khaliulin, I. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.05.008 · Cited by 390 · see citing works

Protein kinase C. Its role in ischemic preconditioning in the rat.

Speechly-Dick, M. E., Mocanu, M. M., & Yellon, D. M. (1994) · Circulation Research · doi:10.1161/01.res.75.3.586 · Cited by 362 · see citing works

Interrupting Reperfusion as a Stroke Therapy: Ischemic Postconditioning Reduces Infarct Size after Focal Ischemia in Rats

Zhao, H., Sapolsky, R. M., & Steinberg, G. K. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600348 · Cited by 338 · see citing works

‘Ischemic tolerance’ phenomenon detected in various brain regions

Kitagawa, K., Matsumoto, M., Kuwabara, K., Tagaya, M., Ohtsuki, T., Hata, R., Ueda, H., Handa, N., Kimura, K., & Kamada, T. (1991) · Brain Research · doi:10.1016/0006-8993(91)91596-s · Cited by 336 · see citing works

Requirement for nitric oxide activation of p21 ras /extracellular regulated kinase in neuronal ischemic preconditioning

Gonzalez‐Zulueta, M., Feldman, A. B., Klesse, L. J., Kalb, R. G., Dillman, J. F., Parada, L. F., Dawson, T. M., & Dawson, V. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.436 · Cited by 315 · see citing works

Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat

Gidday, J. M., Fitzgibbons, J. C., Shah, A. R., & Park, T. S. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90455-3 · Cited by 315 · see citing works

Ischemic Tolerance

Kirino, T. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000040942.89393.88 · Cited by 302 · see citing works

Mitochondria and Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia

Chan, P. H. (2004) · Neurochemical Research · doi:10.1007/s11064-004-6869-x · Cited by 300 · see citing works

Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine

Kin, H., Zatta, A. J., LOFYE, M., AMERSON, B., Halkos, M. E., Kerendi, F., ZHAO, Z., Guyton, R. A., Headrick, J., & Vinten‐Johansen, J. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.015 · Cited by 297 · see citing works

Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia

Pignataro, G., Simon, R. P., & Xiong, Z.-G. (2006) · Brain · doi:10.1093/brain/awl325 · Cited by 289 · see citing works

Phosphoinositide-3-Kinase/Akt Survival Signal Pathways Are Implicated in Neuronal Survival After Stroke

Zhao, H., Sapolsky, R. M., & Steinberg, G. K. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:3:249 · Cited by 274 · see citing works

Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows.

Kuroda, S., & Siesjö, B. K. (1997) · PubMed · Cited by 263 · see citing works

Spreading Depression Induces Tolerance of Cortical Neurons to Ischemia in Rat Brain

Kobayashi, S., Harris, V. A., & Welsh, F. A. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.92 · Cited by 262 · see citing works

Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts

Maulik, N., Watanabe, M., Zu, Y., Huang, C., Cordis, G. A., Schley, J. A., & Das, D. K. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)01109-x · Cited by 250 · see citing works

15d-Prostaglandin J2 Activates Peroxisome Proliferator-Activated Receptor-γ, Promotes Expression of Catalase, and Reduces Inflammation, Behavioral Dysfunction, and Neuronal Loss after Intracerebral Hemorrhage in Rats

Zhao, X., Zhang, Y., Strong, R., Grotta, J. C., & Aronowski, J. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600233 · Cited by 245 · see citing works

Activation of Akt/Protein Kinase B Contributes to Induction of Ischemic Tolerance in the CA1 Subfield of Gerbil Hippocampus

Yano, S., Morioka, M., Fukunaga, K., Kawano, T., Hara, T., Kai, Y., Hamada, J.-I., Miyamoto, E., & Ushio, Y. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200104000-00004 · Cited by 229 · see citing works

Hypoxic Preconditioning Induces Changes in HIF-1 Target Genes in Neonatal Rat Brain

Jones, N. M., & Bergeron, M. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200109000-00008 · Cited by 222 · see citing works

The Role of Cytokines in the Neuropathology of Stroke and Neurotrauma

Feuerstein, G. Z., Wang, X., & Barone, F. C. (1998) · NeuroImmunoModulation · doi:10.1159/000026331 · Cited by 219 · see citing works

Induction of Ischemic Tolerance following Brief Focal Ischemia in Rat Brain

Glazier, S. S., O’Rourke, D. M., Graham, D. I., & Welsh, F. A. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.68 · Cited by 219 · see citing works

Nitric Oxide Mediates Cerebral Ischemic Tolerance in a Neonatal Rat Model of Hypoxic Preconditioning

Gidday, J. M., Shah, A. R., Maceren, R. G., Wang, Q., Pelligrino, D. A., Holtzman, D. M., & Park, T. S. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199903000-00011 · Cited by 217 · see citing works

CREB-Mediated Bcl-2 Protein Expression after Ischemic Preconditioning

Meller, R., Minami, M., Cameron, J. A., Impey, S., Chen, D., Lan, J., Henshall, D. C., & Simon, R. P. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600024 · Cited by 214 · see citing works

The role of inflammation after acute stroke

DeGraba, T. J. (1998) · Neurology · doi:10.1212/wnl.51.3_suppl_3.s62 · Cited by 202 · see citing works

Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system

de la Rosa, D. Á., Krueger, S., Kolar, A., Shao, D., Fitzsimonds, R. M., & Canessa, C. M. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.030692 · Cited by 200 · see citing works

In Vivo and In Vitro Characterization of a Novel Neuroprotective Strategy for Stroke: Ischemic Postconditioning

Pignataro, G., Meller, R., Inoue, K., Ordonez, A. N., Ashley, M. D., Zhi-Gang, X., & Simon, R. P. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600559 · Cited by 196 · see citing works

Activation of the Akt/GSK3β Signaling Pathway Mediates Survival of Vulnerable Hippocampal Neurons after Transient Global Cerebral Ischemia in Rats

Endo, H., Nito, C., Kamada, H., Nishi, T., & Chan, P. H. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600303 · Cited by 193 · see citing works

Ischemic Postconditioning Protects Against Global Cerebral Ischemia/Reperfusion-Induced Injury in Rats

Wang, J., Shen, J. Y., Gao, Q. F., Ye, Z., Yang, S.-Y., Liang, H.-W., Bruce, I. C., Luo, B., & Xia, Q. (2008) · Stroke · doi:10.1161/strokeaha.107.499079 · Cited by 188 · see citing works

Preconditioning Prevents the Inhibition of Na+,K+-ATPase Activity after Brain Ischemia

Wyse, Â. T. D. S., STRECK, E. L., Worm, P. V., Wajner, A., Ritter, F. G., & Netto, C. A. (2000) · Neurochemical Research · doi:10.1023/a:1007504525301 · Cited by 177 · see citing works

Ca 2+ signals and death programmes in neurons

Berliocchi, L., Bano, D., & Nicotera, P. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1765 · Cited by 174 · see citing works

Two Sodium/Calcium Exchanger Gene Products, NCX1 and NCX3, Play a Major Role in the Development of Permanent Focal Cerebral Ischemia

Pignataro, G., Gala, R., Cuomo, O., Tortiglione, A., Giaccio, L., Castaldo, P., Sirabella, R., Matrone, C., Canitano, A., Amoroso, S., et al. (2004) · Stroke · doi:10.1161/01.str.0000143730.29964.93 · Cited by 169 · see citing works

The Akt signaling pathway contributes to postconditioning’s protection against stroke; the protection is associated with the MAPK and PKC pathways

Gao, X., Zhang, H., Takahashi, T., Hsieh, J. K., Liao, J., Steinberg, G. K., & Zhao, H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05218.x · Cited by 166 · see citing works

Physiology and pathophysiology of Na+/H+exchange and Na+-K+-2Cl−cotransport in the heart, brain, and blood

Pedersen, S. F., O’Donnell, M. E., Anderson, S. E., & Cala, P. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00782.2005 · Cited by 165 · see citing works

Endogenous neuroprotection: Mitochondria as gateways to cerebral preconditioning?

Dirnagl, U., & Meisel, A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.02.017 · Cited by 149 · see citing works

The stress gene response in brain.

Massa, S. M., Swanson, R. A., & Sharp, F. R. (1996) · PubMed · Cited by 145 · see citing works

Prior ischemic stress protects against experimental stroke

Simon, R. P., Niiro, M., & Gwinn, R. P. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90364-q · Cited by 141 · see citing works

The role of Na–K–Cl co–transporter in cerebral ischemia

Chen, H., & Sun, D. (2005) · Neurological Research · doi:10.1179/016164105x25243 · Cited by 139 · see citing works

Role of Protein Kinase C in Ischemic Preconditioning: Player or Spectator?

Brooks, G., & Hearse, D. J. (1996) · Circulation Research · doi:10.1161/01.res.79.3.628 · Cited by 138 · see citing works

Remote preconditioning by infrarenal aortic occlusion is operative via δ1-opioid receptors and free radicals in vivo in the rat heart

Weinbrenner, C. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.008 · Cited by 138 · see citing works

TNF-α–Induced Tolerance to Ischemic Injury Involves Differential Control of NF-κB Transactivation: The Role of NF-κB Association with p300 Adaptor

Ginis, I., Jaiswal, R. K., Klimanis, D., Liu, J., Greenspon, J., & Hallenbeck, J. M. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200202000-00002 · Cited by 138 · see citing works

Mutually Protective Actions of Kainic Acid Epileptic Preconditioning and Sublethal Global Ischemia on Hippocampal Neuronal Death: Involvement of Adenosine A 1 Receptors and K ATP Channels

Plamondon, H., Blondeau, N., Heurteaux, C., & Lazdunski, M. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199912000-00002 · Cited by 131 · see citing works

Cerebral ischemic preconditioning

Schaller, B. J., & Graf, R. (2002) · Journal of Neurology · doi:10.1007/s00415-002-0933-8 · Cited by 129 · see citing works

Molecular mechanism of preconditioning

Das, M., & Das, D. K. (2008) · IUBMB Life · doi:10.1002/iub.31 · Cited by 129 · see citing works

Increased tolerance to oxygen and glucose deprivation in astrocytes from Na+/H+ exchanger isoform 1 null mice

Kintner, D. B., Su, G., Lenart, B. A., Ballard, A. J., Meyer, J. W., Ng, L. L., Shull, G. E., & Sun, D. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00560.2003 · Cited by 128 · see citing works

Delayed Postconditionig Initiates Additive Mechanism Necessary for Survival of Selectively Vulnerable Neurons After Transient Ischemia in Rat Brain

Bürda, J., Danielisová, V., Némethová, M., Gottlieb, M., Matiašová, M., Domoráková, I., Mechírová, E., Feriková, M., Salinas, M., & Burda, R. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9036-x · Cited by 116 · see citing works

A rapid capsaicin-activated current in rat trigeminal ganglion neurons.

Liu, L., & Simon, S. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.738 · Cited by 110 · see citing works

Role of Reactive Oxygen Species and Protein Kinase C in Ischemic Tolerance in the Brain

Perez-Pinzon, M., Dave, K., & Raval, A. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1150 · Cited by 108 · see citing works

Realizing the clinical potential of ischemic preconditioning and postconditioning

Yellon, D. M., & Hausenloy, D. J. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0346 · Cited by 105 · see citing works

Preconditioning-induced neuroprotection is mediated by reactive oxygen species

Ravati, A., Ahlemeyer, B., Becker, A., & Krieglstein, J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02210-1 · Cited by 104 · see citing works

Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation after Transient Focal Cerebral Ischemia in Mice

Noshita, N., Sugawara, T., Fujimura, M., Morita‐Fujimura, Y., & Chan, P. H. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200105000-00010 · Cited by 100 · see citing works

Epsilon Protein Kinase C Mediated Ischemic Tolerance Requires Activation of the Extracellular Regulated Kinase Pathway in the Organotypic Hippocampal Slice

Lange‐Asschenfeldt, C., Raval, A. P., Dave, K. R., Mochly‐Rosen, D., Sick, T. J., & Pérez‐Pinzón, M. A. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000121235.42748.bf · Cited by 99 · see citing works

Remote organ ischemic preconditioning protect brain from ischemic damage following asphyxial cardiac arrest

Dave, K. R., Saul, I., Prado, R., Busto, R., & Pérez‐Pinzón, M. A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.037 · Cited by 96 · see citing works

Mild hypoxia preconditioning prevents impairment of passive avoidance learning and suppression of brain NGFI-A expression induced by severe hypoxia

Rybnikova, E. A., Vataeva, L. A., Tyulkova, E. I., Gluschenko, T., Otellin, V. A., Pelto‐Huikko, M., & Samoilov, M. O. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.11.023 · Cited by 96 · see citing works

Induction of ischemic tolerance and antioxidant activity by brief focal ischemia

Toyoda, T., Kassell, N. F., & Lee, K. S. (1997) · Neuroreport · doi:10.1097/00001756-199703030-00008 · Cited by 90 · see citing works

Permanent Focal Brain Ischemia Induces Isoform-Dependent Changes in the Pattern of Na+/Ca2+ Exchanger Gene Expression in the Ischemic Core, Periinfarct Area, and Intact Brain Regions

Boscia, F., Gala, R., Pignataro, G., de Bartolomeis, A., Cicale, M., Ambesi‐Impiombato, A., Renzo, G. D., & Annunziato, L. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600207 · Cited by 87 · see citing works

Changes in Protein Tyrosine Phosphorylation in the Rat Brain after Cerebral Ischemia in a Model of Ischemic Tolerance

Shamloo, M., & Wieloch, T. W. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199902000-00009 · Cited by 86 · see citing works

Role of phosphoinositide 3-kinase in ischemic postconditioning-induced attenuation of cerebral ischemia-evoked behavioral deficits in mice.

Rehni, A. K., & Singh, N. (2008) · PubMed · Cited by 85 · see citing works

Nitric oxide and cerebral ischemic preconditioning

Huang, P. L. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.02.007 · Cited by 84 · see citing works

Thrombolytic Intervention in Acute Thrombotic and Embolic Stroke

del Zoppo, G., Pessin, M. S., Mori, E., & Hacke, W. (1991) · Seminars in Neurology · doi:10.1055/s-2008-1041241 · Cited by 80 · see citing works

Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation

Wang, M., Huang, H. M., Hsieh, S., Jeng, K. C., & Kuo, J. S. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00374-x · Cited by 77 · see citing works

Tolerance-Inducing Dose of 3-Nitropropionic Acid Modulates bcl-2 and bax Balance in the Rat Brain: A Potential Mechanism of Chemical Preconditioning

Brambrink, A. M., Schneider, A., Noga, H., Astheimer, A., Götz, B., Körner, I., Heimann, A., Welschof, M., & Kempski, O. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200010000-00004 · Cited by 77 · see citing works

The Protective Effect of Ischemic Postconditioning Against Ischemic Injury: From the Heart to the Brain

Zhao, H. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9089-8 · Cited by 74 · see citing works

Early Stress Protein Gene Expression in a Human Model of Ischemic Preconditioning

Patel, A., van de Poll, M. C. G., Greve, J. W. M., Buurman, W. A., Fearon, K. C. H., McNally, S. J., Harrison, E. M., Ross, J. A., Garden, O. J., Dejong, C. H. C., et al. (2004) · Transplantation · doi:10.1097/01.tp.0000144182.27897.1e · Cited by 69 · see citing works

The Changes in Endogenous Antioxidant Enzyme Activity After Postconditioning

Danielisová, V., Némethová, M., Gottlieb, M., & Bürda, J. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9034-z · Cited by 68 · see citing works

Early and delayed preconditioning: differential mechanisms and additive protection

Meldrum, D. R., Cleveland, J. C., Rowland, R. T., Banerjee, A. M., Harken, A. H., & Meng, X. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.2.h725 · Cited by 65 · see citing works

Neuroprotection by group I mGlu receptors in a rat hippocampal slice model of cerebral ischemia is associated with the PI3K–Akt signaling pathway: A novel postconditioning strategy?

Scartabelli, T., Gerace, E., Landucci, E., Moroni, F., & Pellegrini-Giampietro, D. E. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.019 · Cited by 64 · see citing works

Opposing functions of Ki- and Ha-Ras genes in the regulation of redox signals

Santillo, M., Mondola, P., Serù, R., Annella, T., Cassano, S., Ciullo, I., Tecce, M. F., Iacomino, G., Damiano, S., Cuda, G., et al. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00159-2 · Cited by 62 · see citing works

Postconditioning, a Series of Brief Interruptions of Early Reperfusion, Prevents Neurologic Injury After Spinal Cord Ischemia

Jiang, X., Shi, E., Nakajima, Y., & Sato, S. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000217608.08582.35 · Cited by 61 · see citing works

Reactive Oxygen Species Signaling through Regulation of Protein Tyrosine Phosphorylation in Endothelial Cells

Natarajan, V., Scribner, W. M., Al‐Hassani, M., & Vepa, S. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s51205 · Cited by 61 · see citing works

Neuronal ischaemic preconditioning

Dawson, V. L., & Dawson, T. M. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01560-1 · Cited by 57 · see citing works

NO‐induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn‐SOD activity and expression via RAS/ERK1/2 pathway

Scorziello, A., Santillo, M., Adornetto, A., Dell’Aversano, C., Sirabella, R., Damiano, S., Canzoniero, L. M. T., Renzo, G. F. D., & Annunziato, L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04845.x · Cited by 57 · see citing works

Calcium Movement in Ischemia-Tolerant Hippocampal CA1 Neurons after Transient Forebrain Ischemia in Gerbils

Ohta, S., Furuta, S., Matsubara, I., Kohno, K., Kumon, Y., & Sakaki, S. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00015 · Cited by 56 · see citing works

Nitric oxide, ischaemia and brain inflammation

Murphy, S. P., & Gibson, C. L. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351133 · Cited by 55 · see citing works

Future Targets and Cascades for Neuroprotective Strategies

Chan, P. H. (2004) · Stroke · doi:10.1161/01.str.0000143325.25610.ac · Cited by 51 · see citing works

Brain tolerance and preconditioning.

Ręjdak, R., Rejdak, K., Sieklucka-Dziuba, M., Stelmasiak, Z., & Grieb, P. (2001) · PubMed · Cited by 44 · see citing works

Molecular conformation dictates signaling module formation: example of PKCε and Src tyrosine kinase

Song, C., Vondriska, T. M., Wang, G., Klein, J. B., Cao, X., Zhang, J., Kang, Y. J., D’Souza, S. E., & Ping, P. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00830.2001 · Cited by 42 · see citing works

Reduced calcium elevation in hippocampal CA1 neurons of ischemia-tolerant gerbils

Shimazaki, K., Nakamura, T., Nakamura, K. M., Oguro, K., Masuzawa, T., Kudo, Y., & Kawai, N. (1998) · Neuroreport · doi:10.1097/00001756-199806010-00038 · Cited by 41 · see citing works

Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats.

Sirén, A., Liu, Y., FEUERSTEIN, G. Z., & Hallenbeck, J. M. (1993) · Stroke · doi:10.1161/01.str.24.6.880 · Cited by 41 · see citing works

Transient glucose and amino acid deprivation induces delayed preconditioning in cultured rat cortical neurons

Gáspár, T., Kis, B., Snipes, J. A., Lenzsér, G., Mayanagi, K., Bari, F., & Busija, D. W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03899.x · Cited by 40 · see citing works

PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis

Hirai, K., Hayashi, T., Chan, P. H., Zeng, J., Yang, G., Basus, V. J., James, T. L., & Litt, L. L. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.02.009 · Cited by 40 · see citing works

Rapid Downregulation of NCX and PMCA in Hippocampal Neurons Following H2O2 Oxidative Stress

Kip, S. N., & Strehler, E. E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1387.005 · Cited by 40 · see citing works

Making the heart resistant to infarction: how can we further decrease infarct size?

Tissier, R. (2007) · Frontiers in bioscience · doi:10.2741/2679 · Cited by 39 · see citing works

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

Willaime‐Morawek, S., Arbez, N., Mariani, J., & Brugg, B. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.09.020 · Cited by 39 · see citing works

Induction of ischaemic tolerance in gerbil hippocampus by pretreatment with focal ischaemia

Miyashita, K., Abé, H., Nakajima, T., Ishikawa, A., Nishiura, M., Sawada, T., & Naritomi, H. (1994) · Neuroreport · doi:10.1097/00001756-199412300-00013 · Cited by 34 · see citing works

Graded Postischemic Reoxygenation Ameliorates Inhibition of Cerebral Cortical Protein Synthesis in Dogs

Bürda, J., Maršala, M., Radoňak, J., & Mars̆ala, J. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.167 · Cited by 33 · see citing works

Using Proteomics to Mine Genome Sequences

Arthur, J. W., & Wilkins, M. R. (2004) · Journal of Proteome Research · doi:10.1021/pr034056e · Cited by 32 · see citing works

Antileukocyte adhesion therapy

Clark, W. M., & Zivin, J. A. (1997) · Neurology · doi:10.1212/wnl.49.5_suppl_4.s32 · Cited by 30 · see citing works

Differential effects of sublethal ischemia and chemical preconditioning with 3-nitropropionic acid on protein expression in gerbil hippocampus

Kato, K., Shimazaki, K., Kamiya, T., Amemiya, S., Inaba, T., Oguro, K., & Katayama, Y. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.01.037 · Cited by 23 · see citing works

Short-term postischemic hypoperfusion improves recovery of protein synthesis in the rat brain cortex

Bürda, J., Gottlieb, M., Vanický, I., Chavko, M., & Mars̆ala, J. (1995) · Molecular and Chemical Neuropathology · doi:10.1007/bf02960912 · Cited by 22 · see citing works

Modification of the subclavian patch aortoplasty for repair of aortic coarctation in neonates and infants

Allen, B. S., Halldorsson, A., Barth, M. J., & Ilbawi, M. N. (2000) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)01503-9 · Cited by 22 · see citing works

Post‐conditioning exacerbates the MnSOD immune‐reactivity after experimental cerebral global ischemia and reperfusion in the rat brain hippocampus

Némethová, M., Danielisová, V., Gottlieb, M., & Bürda, J. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.08.023 · Cited by 19 · see citing works

Reactive Oxygen Species Signaling through Regulation of Protein Tyrosine Phosphorylation in Endothelial Cells

Natarajan, V., Scribner, W. M., Al‐Hassani, M., et al. (1998) · Environmental Health Perspectives · doi:10.2307/3433987 · Cited by 13 · see citing works

[Evaluation of G(i/o) protein signal transduction pathway in cardioprotection of hypoxic preconditioning].

Chen, Y. Y., & Xia, Q. (2000) · PubMed · Cited by 4 · see citing works

Anti-apoptosis and cell survival: A review

Portt, L., Norman, G., Clapp, C., Greenwood, M., & Greenwood, M. T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.010 · Cited by 640 · see citing works

Pathogenic mechanisms following ischemic stroke

Khoshnam, S. E., Winlow, W., Farzaneh, M., Farbood, Y., & Moghaddam, H. F. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2938-1 · Cited by 618 · see citing works

Protein Oxidative Modifications: Beneficial Roles in Disease and Health.

Cai, Z., & Yan, L. (2013) · PubMed · Cited by 226 · see citing works

Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Fan, Y., Chen, Z., & Zhang, M. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03493-6 · Cited by 134 · see citing works

Inorganic nitrite therapy: historical perspective and future directions

Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death

Miyawaki, T., Ofengeim, D., Noh, K., Latuszek-Barrantes, A., Hemmings, B. A., Follenzi, A., & Zukin, R. S. (2009) · Nature Neuroscience · doi:10.1038/nn.2299 · Cited by 108 · see citing works

Long-lasting protection in brain trauma by endotoxin preconditioning

Longhi, L. G., Gesuete, R., Perego, C., Ortolano, F., Sacchi, N., Villa, P., Stocchetti, N., & Simoni, M. G. D. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.42 · Cited by 99 · see citing works

Neuroprotective Effect of Sodium Butyrate against Cerebral Ischemia/Reperfusion Injury in Mice

Sun, J., Wang, F., Li, H., Zhang, H., Jin, J., Chen, W., Pang, M., Yu, J., He, Y., Liu, J., et al. (2015) · BioMed Research International · doi:10.1155/2015/395895 · Cited by 95 · see citing works

CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

Stowe, A. M., Wacker, B. K., Cravens, P. D., Perfater, J. L., Li, M. K., Hu, R., Freie, A. B., Stüve, O., & Gidday, J. M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-33 · Cited by 90 · see citing works

Intracellular Signaling MAPK Pathway After Cerebral Ischemia–Reperfusion Injury

Kovalská, M., Kovalska, L., Pavlikova, M., Janíčková, M., Mikušková, K., Adamkov, M., Kaplán, P., Tatarková, Z., & Lehotský, J. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0752-y · Cited by 82 · see citing works

Excitatory and inhibitory amino acid neurotransmitters in stroke: from neurotoxicity to ischemic tolerance

Amantea, D., & Bagetta, G. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.07.014 · Cited by 80 · see citing works

Ischemic Tolerance: The Mechanisms of Neuroprotective Strategy

Lehotský, J., Bürda, J., Danielisová, V., Gottlieb, M., Kaplán, P., & Sániová, B. D. (2009) · The Anatomical Record · doi:10.1002/ar.20970 · Cited by 78 · see citing works

Neuroprotection in Acute Ischemic Stroke: A Battle Against the Biology of Nature

Ghozy, S. A., Reda, A., Varney, J., ElHawary, A. S., Shah, J., Murry, K., Sobeeh, M. G., Nayak, S. S., Azzam, A. Y., Brinjikji, W., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.870141 · Cited by 77 · see citing works

Diffuse optical monitoring of repeated cerebral ischemia in mice

Shang, Y., Chen, L., Toborek, M. J., & Yu, G. (2011) · Optics Express · doi:10.1364/oe.19.020301 · Cited by 76 · see citing works

SIRT3 protects cells from hypoxia via PGC-1α- and MnSOD-dependent pathways

Wang, Q., Li, L., Li, C. Y., Pei, Z., Zhou, M., & Li, N. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.045 · Cited by 76 · see citing works

NCX1 Is a Novel Target Gene for Hypoxia-Inducible Factor-1 in Ischemic Brain Preconditioning

Valsecchi, V., Pignataro, G., Prete, A. D., Sirabella, R., Matrone, C., Boscia, F., Scorziello, A., Sisalli, M. J., Esposito, E., Zambrano, N., et al. (2011) · Stroke · doi:10.1161/strokeaha.110.597583 · Cited by 75 · see citing works

nNOS and p-ERK involvement in the neuroprotection exerted by remote postconditioning in rats subjected to transient middle cerebral artery occlusion

Pignataro, G., Esposito, E., Sirabella, R., Vinciguerra, A., Cuomo, O., Renzo, G. D., & Annunziato, L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.02.008 · Cited by 73 · see citing works

Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system

Licastro, E., Pignataro, G., Iliff, J. J., Xiang, Y., Lo, E. H., Hayakawa, K., & Esposito, E. (2024) · Communications Biology · doi:10.1038/s42003-024-05911-5 · Cited by 69 · see citing works

Phenotyping of an in Vitro Model of Ischemic Penumbra by iTRAQ-Based Shotgun Quantitative Proteomics

Datta, A., Park, J. E., Li, X., Zhang, H., Ho, Z. S., Heese, K., Lim, S. K., Tam, J. P., & Sze, S. K. (2009) · Journal of Proteome Research · doi:10.1021/pr900829h · Cited by 66 · see citing works

The nutraceutical potential of omega-3 alpha-linolenic acid in reducing the consequences of stroke

Blondeau, N. (2015) · Biochimie · doi:10.1016/j.biochi.2015.06.005 · Cited by 58 · see citing works

The NCX3 Isoform of the Na + /Ca 2+ Exchanger Contributes to Neuroprotection Elicited by Ischemic Postconditioning

Pignataro, G., Esposito, E., Cuomo, O., Sirabella, R., Boscia, F., Guida, N., Renzo, G. D., & Annunziato, L. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.100 · Cited by 54 · see citing works

Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the Same Effect on Inhibition of Apoptosis

Ding, Z.-M., Wu, B., Zhang, W.-Q., Lu, X.-J., Lin, Y.-C., Geng, Y., & Miao, Y.-F. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13056089 · Cited by 54 · see citing works

Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury

Khan, H., Singh, A., Thapa, K., Garg, N., Grewal, A. K., & Singh, T. G. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147399 · Cited by 53 · see citing works

Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition

Xia, D., Li, W., Qian, H. R., Yao, S., Liu, J. G., & Qi, X. K. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20133161 · Cited by 50 · see citing works

Long-term behavioral and biochemical effects of an ultra-low dose of Δ9-tetrahydrocannabinol (THC): neuroprotection and ERK signaling

Fishbein, M., Gov, S., Assaf, F., Gafni, M., Keren, O., & Sarne, Y. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3186-5 · Cited by 45 · see citing works

Neuroprotection Induced In Vitro by Ischemic Preconditioning and Postconditioning: Modulation of Apoptosis and PI3K–Akt Pathways

Prasad, S. S., Russell, M. S., & Nowakowska, M. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9461-7 · Cited by 44 · see citing works

Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury

Park, H. R., Lee, H.-E., Lee, J., Yim, N., Gu, M.-J., & Yeul, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0652-x · Cited by 43 · see citing works

Environmental and Genetic Preconditioning for Long-Term Anoxia Responses Requires AMPK in Caenorhabditis elegans

LaRue, B., & Padilla, P. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016790 · Cited by 41 · see citing works

NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning

Pignataro, G., Cuomo, O., Vinciguerra, A., Sirabella, R., Esposito, E., Boscia, F., Renzo, G. D., & Annunziato, L. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4756-6_19 · Cited by 41 · see citing works

ASIC1a contributes to neuroprotection elicited by ischemic preconditioning and postconditioning.

Pignataro, G., Cuomo, O., Esposito, E., Sirabella, R., Renzo, G. D., & Annunziato, L. (2011) · Europe PMC (PubMed Central) · Cited by 40 · see citing works

Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target

Jin, Z., Wu, J., & Yan, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030351 · Cited by 40 · see citing works

Pre- and post-conditioning treatment with an ultra-low dose of Δ9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage

Assaf, F., Fishbein, M., Gafni, M., Keren, O., & Sarne, Y. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.005 · Cited by 40 · see citing works

Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca2+ exchanger 3 downregulation

Anzilotti, S., Brancaccio, P., Simeone, G., Valsecchi, V., Vinciguerra, A., Secondo, A., Petrozziello, T., Guida, N., Sirabella, R., Cuomo, O., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0227-9 · Cited by 39 · see citing works

Ionic homeostasis in brain conditioning

Cuomo, O., Vinciguerra, A., Cerullo, P., Anzilotti, S., Brancaccio, P., Bilo, L., Scorziello, A., Molinaro, P., Renzo, G. D., & Pignataro, G. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00277 · Cited by 38 · see citing works

Bererine induces peripheral lymphocytes immune regulations to realize its neuroprotective effects in the cerebral ischemia/reperfusion mice

Song, B., Tang, X., Wang, X., Huang, X., Ye, Y., Lu, X., Wei, X., & Zeng, Y. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.04.006 · Cited by 34 · see citing works

Is it Time to Retire the A.V. Hill Model?

Noakes, T. D. (2011) · Sports Medicine · doi:10.2165/11583950-000000000-00000 · Cited by 33 · see citing works

Vitamin D as therapeutic modulator in cerebrovascular diseases: a mechanistic perspectives

Rihal, V., Khan, H., Kaur, A., & Singh, T. G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2050349 · Cited by 32 · see citing works

Beneficial and deleterious effects of cannabinoids in the brain: the case of ultra-low dose THC

Sarne, Y. (2019) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2019.1578366 · Cited by 32 · see citing works

Interrupted reperfusion reduces the activation of NADPH oxidase after cerebral I/R injury

Shen, J. Y., Bai, X., Qin, Y. H., Jin, W., Zhou, J.-Y., Zhou, J., Yan, Y.-G., Wang, Q., Bruce, I. C., Chen, J., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.028 · Cited by 30 · see citing works

Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1

Matić, I., Cocco, S., Ferraina, C., Martín-Jiménez, R., Florenzano, F., Crosby, J., Lupi, R., Amadoro, G., Russell, C., Pignataro, G., et al. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.10.010 · Cited by 29 · see citing works

Novel Cellular Mechanisms for Neuroprotection in Ischemic Preconditioning: A View from Inside Organelles

Sisalli, M. J., Annunziato, L., & Scorziello, A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00115 · Cited by 27 · see citing works

Post-ischemic administration of 5-methoxyindole-2-carboxylic acid at the onset of reperfusion affords neuroprotection against stroke injury by preserving mitochondrial function and attenuating oxidative stress

Wu, J., Jin, Z. H., Yang, X., & Yan, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.106 · Cited by 27 · see citing works

Lipopolysaccharide preconditioning attenuates neuroapoptosis and improves functional recovery through activation of Nrf2 in traumatic spinal cord injury rats

Li, W., Jiang, D., Hu, N., Qi, X.-T., Qiao, B., & Luo, X. (2012) · International Journal of Neuroscience · doi:10.3109/00207454.2012.755181 · Cited by 25 · see citing works

Hepatoprotective effects of limb ischemic post-conditioning in hepatic ischemic rat model and liver cancer patients via PI3K/ERK pathways

Gao, Y., Zhou, S. Y., Wang, F., Zhou, Y., Sheng, S., Qi, D., Huang, J. H., Wu, E., Lv, Y., & Huo, X. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.28435 · Cited by 25 · see citing works

p-ERK involvement in the neuroprotection exerted by ischemic preconditioning in rat hippocampus subjected to four vessel occlusion.

Kovalská, M., Kovalska, L., Mikušková, K., Adamkov, M., Tatarková, Z., & Lehotský, J. (2014) · PubMed · Cited by 24 · see citing works

Cross-talk of intracellular calcium stores in the response to neuronal ischemia and ischemic tolerance.

Lehotský, J., Račay, P., Pavlíková, M., Tatarková, Z., Urban, P., Chomová, M., Kovalská, M., & Kaplán, P. (2009) · PubMed · Cited by 24 · see citing works

Hypobaric Hypoxia Postconditioning Reduces Brain Damage and Improves Antioxidative Defense in the Model of Birth Asphyxia in 7-Day-Old Rats

Gamdzyk, M., Makarewicz, D., Słomka, M., Ziembowicz, A., & Salińska, E. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1191-0 · Cited by 22 · see citing works

Eradicating the Mediators of Neuronal Death with a Fine-Tooth Comb

Zukin, R. S. (2010) · Science Signaling · doi:10.1126/scisignal.3125pe20 · Cited by 22 · see citing works

Transcriptional and epigenetic regulation of ncx1 and ncx3 in the brain

Formisano, L., Guida, N., Mascolo, L., Serani, A., Laudati, G., Pizzorusso, V., & Annunziato, L. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102194 · Cited by 22 · see citing works

Preconditioning and postconditioning for neuroprotection: The most recent evidence

Fairbanks, S. L., & Brambrink, A. M. (2010) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2010.10.004 · Cited by 21 · see citing works

Response of secretory pathways Ca2+ ATPase gene expression to hyperhomocysteinemia and/or ischemic preconditioning in rat cerebral cortex and hippocampus

Pavlikova, M., Kovalská, M., Tatarková, Z., Sivoňová, M. K., Kaplán, P., & Lehotský, J. (2011) · General Physiology and Biophysics · doi:10.4149/gpb_2011_si1_61 · Cited by 21 · see citing works

Hypoxia-induced mediators and neurologic disease

Benarroch, E. E. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b2a719 · Cited by 20 · see citing works

Post-ischemic conditioning in the rat retina is dependent upon ischemia duration and is not additive with ischemic pre-conditioning

Dreixler, J. C., Shaikh, A. R., Alexander, M. J., Savoie, B. T., & Roth, S. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.06.015 · Cited by 19 · see citing works

Modulation of Cerebral Store-operated Calcium Entry-regulatory Factor (SARAF) and Peripheral Orai1 Following Focal Cerebral Ischemia and Preconditioning in Mice

Russa, D. L., Frisina, M., Secondo, A., Bagetta, G., & Amantea, D. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.014 · Cited by 18 · see citing works

Delayed post-ischemic conditioning significantly improves the outcome after retinal ischemia

Dreixler, J. C., Poston, J. N., Shaikh, A. R., Alexander, M. J., Tupper, K. Y., Marcet, M. M., Bernaudin, M., & Roth, S. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.03.015 · Cited by 18 · see citing works

Long‐lasting neuroprotective effect of sildenafil against 3,4‐methylenedioxymethamphetamine‐ induced 5‐hydroxytryptamine deficits in the rat brain

Puerta, E., Barros-Miñones, L., Hervías, I., Gomez‐Rodriguez, V., Orejana, L., Pizarro, N., de la Torre, R., Jordán, J., & Aguirre, N. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22759 · Cited by 18 · see citing works

Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage

Yang, H., Qi, C., Su, F., Shan, W., Guo, A., Wu, J., Wang, Y., You, H., & Wang, Q. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03789-5 · Cited by 17 · see citing works

Peroxisome proliferator activated receptor (PPAR)-γ co-activator 1-α and hypoxia induced factor-1α mediate neuro- and vascular protection by hypoxic preconditioning in vitro

Zhao, J., Li, L., Pei, Z., Li, Z., Wei, H. J., Zhang, B., Peng, Y., Wang, Y., Tao, Y., & Huang, R. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.059 · Cited by 16 · see citing works

Effect of ischemic postconditioning on cerebral edema and the AQP4 expression following hypoxic-eschemic brain damage in neonatal rats

Yu, L., Fan, S., Liu, L., Xiao, M., Lin, X., Liu, Y., Lv, H., Chen, X., & Liu, J. (2014) · World Journal of Pediatrics · doi:10.1007/s12519-014-0519-4 · Cited by 16 · see citing works

Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures

Bingham, D., John, C. M., Panter, S. S., & Jarvis, G. A. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.04.007 · Cited by 16 · see citing works

Correlation study between small vessel disease and early neurological deterioration in patients with mild/moderate acute ischemic stroke

Chen, Z., Li, W., Sun, W., Xiao, L., Dai, Q., Cao, Y., Han, Y., Zhu, W., Xu, G., & Liu, X. (2016) · International Journal of Neuroscience · doi:10.1080/00207454.2016.1214825 · Cited by 16 · see citing works

Transcriptional Regulation of ncx1 Gene in the Brain

Valsecchi, V., Pignataro, G., Sirabella, R., Matrone, C., Boscia, F., Scorziello, A., Sisalli, M. J., Esposito, E., Zambrano, N., Cataldi, M., et al. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4756-6_12 · Cited by 15 · see citing works

Gene Expression Analysis to Identify Molecular Correlates of Pre- and Post-conditioning Derived Neuroprotection

Prasad, S. S., Russell, M. S., Nowakowska, M., Williams, A., & Yauk, C. L. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9751-3 · Cited by 15 · see citing works

Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets

Zhao, Y., Dou, J., Luo, J., Li, W., Chan, H. H. N., Cui, W., Zhang, H., Han, R., Carlier, P. R., Zhang, X., et al. (2011) · Brain Research · doi:10.1016/j.brainres.2011.09.014 · Cited by 15 · see citing works

Possible Involvement of Oxidative Stress and Inflammatory Mediators in the Protective Effects of the Early Preconditioning Window Against Transient Global Ischemia in Rats

Nassar, N. N., Abdelsalam, R. M., Abdel‐Rahman, A. A., & Abdallah, D. M. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0651-7 · Cited by 15 · see citing works

Brief anoxia preconditioning and HIF prolyl-hydroxylase inhibition enhances neuronal resistance in organotypic hippocampal slices on model of ischemic damage

Lushnikova, I., Orlovsky, M., Dosenko, V., Maistrenko, A., & Skibo, G. G. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.033 · Cited by 14 · see citing works

Neuroanesthesiology Update 2010

Pasternak, J. J., & Lanier, W. L. (2011) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0b013e318210f594 · Cited by 14 · see citing works

Melatonin-Induced Postconditioning Suppresses NMDA Receptor through Opening of the Mitochondrial Permeability Transition Pore via Melatonin Receptor in Mouse Neurons

Furuta, T., Nakagawa, I., Yokoyama, S., Morisaki, Y., Saito, Y., & Nakase, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073822 · Cited by 13 · see citing works

Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia

Kostyuk, A. I., Kokova, A. D., Podgorny, O. V., Kelmanson, I. V., Fetisova, E. S., Belousov, V. V., & Bilan, D. S. (2020) · Antioxidants · doi:10.3390/antiox9060516 · Cited by 13 · see citing works

The dynamic detection of NO during the ischemic postconditioning against global cerebral ischemia/reperfusion injury

Liu, K., Yan, M., Zheng, X., & Yang, Y. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.02.002 · Cited by 12 · see citing works

Systemic delivery of microRNA for treatment of brain ischemia

Liu, C., Wen, J., Li, D., Qi, H., Nih, L. R., Zhu, J., Xu, D., Ren, Y., Zhang, S., Han, D., et al. (2021) · Nano Research · doi:10.1007/s12274-021-3413-8 · Cited by 12 · see citing works

Transient Lack of Glucose but not O2 is Involved in Ischemic Postconditioning‐Induced Neuroprotection

Fan, Y., Zhang, X., He, P., Shen, Z., Shen, Y., Wang, X., Hu, W., & Chen, Z. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12033 · Cited by 12 · see citing works

Mitochondrial Calcium Uniporter (MCU) is Involved in an Ischemic Postconditioning Effect Against Ischemic Reperfusion Brain Injury in Mice

Sasaki, H., Nakagawa, I., Furuta, T., Yokoyama, S., Morisaki, Y., Saito, Y., & Nakase, H. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01464-7 · Cited by 11 · see citing works

GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na + -Ca 2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection

Guida, N., Mascolo, L., Serani, A., Cuomo, O., Anzilotti, S., Brancaccio, P., Pignataro, G., Molinaro, P., Annunziato, L., & Formisano, L. (2021) · Stroke · doi:10.1161/strokeaha.121.034637 · Cited by 11 · see citing works

Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage

Esposito, E., Mandeville, E. T., & Lo, E. H. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-129 · Cited by 11 · see citing works

Pharmacologic pre- and postconditioning for stroke: Basic mechanisms and translational opportunity

Lo, E. H., Esposito, E., Desai, R., & Ji, X. (2015) · Brain Circulation · doi:10.4103/2394-8108.166380 · Cited by 11 · see citing works

Association of endothelial nitric oxide synthase polymorphism G894T with functional outcome in acute stroke patients

Ellul, J., Markoula, S., Marousi, S., Galidi, A., Kyritsis, A. P., Papathanasopoulos, P., & Georgiou, I. A. (2011) · Neurological Research · doi:10.1179/1743132811y.0000000011 · Cited by 9 · see citing works

Histochemical Mapping of hnRNP A2/B1 in Rat Brain After Ischemia–Reperfusion Insults

Liu, Y., Gao, Y., Wu, Y. L., Wu, Y., Wang, H., & Zhang, C. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955021 · Cited by 9 · see citing works

A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners

Yang, Y., Zheng, Z., Chen, Y., Wang, X., Wang, H., Si, Z., Meng, R., & Wu, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-29491-2 · Cited by 8 · see citing works

Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): Neurodegeneration versus Neuromodulation

Puerta, E., & Aguirre, N. (2011) · Pharmaceuticals · doi:10.3390/ph4070992 · Cited by 6 · see citing works

Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke

Valente, A., Mariani, J., Seminara, S., Tettamanti, M., Pignataro, G., Perego, C., Sironi, L., Pedata, F., Amantea, D., Bacigaluppi, M., et al. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231159958 · Cited by 5 · see citing works

Novel experimental model for repeated forebrain ischemia-reperfusion

Chen, L., Shang, Y., Sipos, E., Saatman, K. E., Yu, G., & Toborek, M. J. (2012) · Journal of Experimental Stroke and Translational Medicine · doi:10.6030/1939-067x-5.1.1 · Cited by 5 · see citing works

EPCs-Collagen Sponge Complex Promotes Neovascularization of Chronic Cerebral Ischemia following Multiple Burr Hole (MBH) Surgery

Dong-wei, D. A. I., & Zhang, X. (2016) · Journal of Neurological Disorders · doi:10.4172/2329-6895.1000274 · Cited by 3 · see citing works

Mechanisms of Calcium Influx Following Stroke

Belrose, J. C., Caetano, F. A., Yang, K., Lockhart, B. M. W., Jackson, M. F., & MacDonald, J. F. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9663-3_2 · Cited by 3 · see citing works

Dynamics of lipid peroxidation of membranes in cells and mitochondrial fraction of neocortex in non- and preconditioned rats after severe hypobaric hypoxia

Kislin, V. S., Tyulkova, E. I., & Самойлов, М. О. (2011) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093011020083 · Cited by 3 · see citing works

Preconditioning of Caenorhabditis elegans to anoxic insult by inactivation of cholinergic, GABAergic and muscle activity

Bennett, H., McClanahan, P. D., Fang-Yen, C. M., & Kalb, R. G. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12713 · Cited by 2 · see citing works

Time course of lipid peroxidation in hippocampal membranes of preconditioned and nonpreconditioned rats subjected to severe hypobaric hypoxia

Kislin, M., Tyulkova, E. I., & Самойлов, М. О. (2010) · Neurochemical Journal · doi:10.1134/s1819712410020066 · Cited by 2 · see citing works

Transcriptome analysis revealed that ischemic post-conditioning suppressed the expression of inflammatory genes in lung ischemia-reperfusion injury

Lin, L., Sun, C. M., Ye, Y., Zhu, P., Pan, K., & Chen, L. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1425420 · Cited by 1 · see citing works

Propionic acid abrogates the deleterious effects of cerebral ischemic reperfusion injury through nuclear factor-κb signaling in mice

Sun, Z., Yang, T., Wang, Y., Li, C., Yang, Y., Wang, D., Guo, J., Shi, T., Wang, Y., Qu, Y., et al. (2020) · Pharmacognosy Magazine · doi:10.4103/pm.pm_306_19 · Cited by 1 · see citing works

Mechanisms of Ischemic Induced Neuronal Death and Ischemic Tolerance

Lehotský, J., Pavlikova, M., Straka, S., Kovalská, M., Kaplán, P., & Tatarkov�, Z. (2012) · InTech eBooks · doi:10.5772/32112

NR4A orphan nuclear receptors in immediate early regulation of retinoid signaling and neuroprotection

Volakakis, N. (2010) · Figshare

Neuroprotective Mechanisms of Intermittent Hypoxia: An In Vitro Study

Skibo, G. G., Orlovsky, M., Maistrenko, A., Dosenko, V., & Lushnikova, I. (2012) · Springer eBooks · doi:10.1007/978-1-4471-2906-6_14

Probing Water Dynamics in Acute Cerebral Ischemia by MRI

Jokivarsi, K. T. (2009)

İskemik Önkoşullamanın Klinik Önemi

Öncel, T. U., Dinçer, P. Ç., & Cinel, İ. (2012)

Discovery of potential therapeutic targets and biomarkers for ischemic stroke by quantitative proteomics

Arnab, D. (2012) · doi:10.32657/10356/60746

Surgical Methods to Induce Brain Preconditioning

Pignataro, G., Cuomo, O., & Vinciguerra, A. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9695-4_10

Faculty Opinions recommendation of The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.

Choi, E. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1159158.619463

Mitochondrial Contribution to the Pathophysiology of Cerebral Ischemia

Mayevsky, A., Livnat, A., Mendelman, A., & Etziony, R. (2026) · Springer eBooks · doi:10.1007/978-3-032-13019-8_5

Mechanisms of Innate Neuroprotection

(2016) · Frontiers research topics · doi:10.3389/978-2-88919-929-7

NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning

Micieli, G., & Amantea, D. (2014) · CRC Press eBooks · doi:10.1201/b16285-28

From Rapid to Delayed and Remote Postconditioning: The Evolving Concept of Ischemic Postconditioning in Brain Ischemia

Zhao, H., Ren, C., Chen, X., & Shen, J. (2012) · Current Drug Targets · doi:10.2174/138945012799201621 · Cited by 105 · see citing works

Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage

Yang, H., Qi, C., Su, F., Shan, W., Guo, A., Wu, J., Wang, Y., You, H., & Wang, Q. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03789-5 · Cited by 17 · see citing works

Ischemic conditioning-induced endogenous brain protection: Applications pre-, per- or post-stroke

Wang, Y., Reis, C., Applegate, R. L., Stier, G. R., Martin, R., & Zhang, J. H. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.009 · Cited by 113 · see citing works