Cited by 292Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchVirology and Viral Diseases

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Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry

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Akhtar, Jihan, Shukla, Deepak·2009·The FEBS Journal

DOI 10.1111/j.1742-4658.2009.07402.xPMC PMC2801626

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Abstract

Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐long infections. The process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. This initial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors, leading to penetration of the viral nucleocapsid and tegument proteins into the cytoplasm. The nucleocapsid is then transported to the nuclear membrane and the viral DNA is released for replication in the nucleus. Recent studies have revealed that herpes simplex virus entry or penetration into cells may be a highly complex process and the mechanism of entry may demonstrate unique cell‐type specificities. Although specificities clearly exist, past and ongoing studies demonstrate that herpes simplex virus may share certain common receptors and pathways that are also used by many other human viruses. This minireview helps to shed light on recent revelations on the herpes simplex virus entry process.

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Authors: Akhtar, J., & Shukla, D.
Affiliations: University of Illinois Chicago (US)
Corresponding author: Shukla, Deepak
ORCID: Shukla, Deepak
Venue: The FEBS Journal
Publisher: Wiley
Published: 2009-11-27
Volume: 276
Issue: 24
Pages: 7228-7236
ISSN: 1742-464X (ISSN-L)
1742-4658
DOI: 10.1111/j.1742-4658.2009.07402.x
PMC: PMC2801626
OpenAlex: W1501808502
Cited by: 292
References: 48
Citations by year: 2026: 7 · 2025: 8 · 2024: 17 · 2023: 15 · 2022: 17 · 2021: 18 · 2020: 19 · 2019: 14 · 2018: 18 · 2017: 23 · 2016: 23 · 2015: 21 · 2014: 20 · 2013: 17 · 2012: 20
FWCI: 2.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Journal (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Research to Prevent Blindness
National Institutes of Health
National Eye Institute (EY 01792, P30EY001792)
National Institute of Allergy and Infectious Diseases (R01AI057860)
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: herpes simplex virus type 1, herpes simplex virus type 2, viral entry, heparan sulfate, viral attachment, tegument proteins, viral DNA replication, cell type specificity, host-virus interaction
MeSH terms: Cell Communication, Humans, Membrane Fusion, Membrane Glycoproteins, Pseudopodia, Receptors, Immunologic, Viral Envelope Proteins, Herpesvirus 2, Human, Herpesvirus 1, Human, Heparan Sulfate Proteoglycans, Virus Internalization

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Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry

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