The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry
Open accessAbstract
Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐long infections. The process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. This initial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors, leading to penetration of the viral nucleocapsid and tegument proteins into the cytoplasm. The nucleocapsid is then transported to the nuclear membrane and the viral DNA is released for replication in the nucleus. Recent studies have revealed that herpes simplex virus entry or penetration into cells may be a highly complex process and the mechanism of entry may demonstrate unique cell‐type specificities. Although specificities clearly exist, past and ongoing studies demonstrate that herpes simplex virus may share certain common receptors and pathways that are also used by many other human viruses. This minireview helps to shed light on recent revelations on the herpes simplex virus entry process.
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Citations
Cites
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A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry
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Self-citationRegulated Diversity of Heparan Sulfate*
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Self-citationActin- and myosin-driven movement of viruses along filopodia precedes their entry into cells
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Research works printed but not linked: 1
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Sorted by citations
Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans
Lang, J., Yang, N., Deng, J., Liu, K., Yang, P., Zhang, G., & Jiang, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023710 · Cited by 429
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
Cagno, V., Tseligka, E. D., Jones, S. T., & Tapparel, C. (2019) · Viruses · doi:10.3390/v11070596 · Cited by 393
Recognition of herpesviruses by the innate immune system
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Pharmacology of Heparin and Related Drugs
Mulloy, B., Hogwood, J., Gray, E., Lever, R., & Page, C. P. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.011247 · Cited by 355
Herpes Virus Fusion and Entry: A Story with Many Characters
Eisenberg, R. J., Atanasiu, D., Cairns, T. M., Gallagher, J. R., Krummenacher, C., & Cohen, G. H. (2012) · Viruses · doi:10.3390/v4050800 · Cited by 318
Metadata
- Authors
- Akhtar, J., & Shukla, D.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Shukla, Deepak
- ORCID
- Shukla, Deepak
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2009-11-27
- Volume
- 276
- Issue
- 24
- Pages
- 7228-7236
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- PMC
- PMC2801626
- OpenAlex
- W1501808502
- Cited by
- 292
- References
- 48
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 17 · 2023: 15 · 2022: 17 · 2021: 18 · 2020: 19 · 2019: 14 · 2018: 18 · 2017: 23 · 2016: 23 · 2015: 21 · 2014: 20 · 2013: 17 · 2012: 20
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Research to Prevent Blindness
- National Institutes of Health
- National Eye Institute (EY 01792, P30EY001792)
- National Institute of Allergy and Infectious Diseases (R01AI057860)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- herpes simplex virus type 1, herpes simplex virus type 2, viral entry, heparan sulfate, viral attachment, tegument proteins, viral DNA replication, cell type specificity, host-virus interaction
- MeSH terms
- Cell Communication, Humans, Membrane Fusion, Membrane Glycoproteins, Pseudopodia, Receptors, Immunologic, Viral Envelope Proteins, Herpesvirus 2, Human, Herpesvirus 1, Human, Heparan Sulfate Proteoglycans, Virus Internalization
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